Gene description for MTHFD2
Gene name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene symbol MTHFD2
Other names/aliases NMDMC
Species Homo sapiens
 Database cross references - MTHFD2
ExoCarta ExoCarta_10797
Entrez Gene 10797
HGNC 7434
MIM 604887
UniProt P13995  
 MTHFD2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MTHFD2
Molecular Function
    methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 IDA
    methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487 IDA
    methenyltetrahydrofolate cyclohydrolase activity GO:0004477 ISS
    phosphate ion binding GO:0042301 IDA
    formate-tetrahydrofolate ligase activity GO:0004329 IBA
    magnesium ion binding GO:0000287 IDA
Biological Process
    folic acid-containing compound biosynthetic process GO:0009396 IEA
    oxidation-reduction process GO:0055114 IEA
    tetrahydrofolate metabolic process GO:0046653 IDA
    one-carbon metabolic process GO:0006730 IBA
Subcellular Localization
    extracellular space GO:0005615 IDA
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 IBA
 Experiment description of studies that identified MTHFD2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MTHFD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMD13 5719
Affinity Capture-MS Homo sapiens
2 PARP3 10039
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MTHFD2 is involved
No pathways found

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