Gene description for CALD1
Gene name caldesmon 1
Gene symbol CALD1
Other names/aliases CDM
H-CAD
HCAD
L-CAD
LCAD
NAG22
Species Homo sapiens
 Database cross references - CALD1
ExoCarta ExoCarta_800
Vesiclepedia VP_800
Entrez Gene 800
HGNC 1441
MIM 114213
UniProt Q05682  
 CALD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CALD1
Molecular Function
    actin binding GO:0003779 IBA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    tropomyosin binding GO:0005523 TAS
    myosin binding GO:0017022 IBA
    cadherin binding GO:0045296 HDA
Biological Process
    muscle contraction GO:0006936 IEA
    actin filament bundle assembly GO:0051017 IBA
Subcellular Localization
    stress fiber GO:0001725 IEA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 TAS
    plasma membrane GO:0005886 IDA
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IDA
    myofibril GO:0030016 IEA
    actin cap GO:0030478 IEA
 Experiment description of studies that identified CALD1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CALD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPSM2  
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 LDHA 3939
Affinity Capture-MS Homo sapiens
4 HNRNPH1 3187
Co-fractionation Homo sapiens
5 LUZP4  
Affinity Capture-MS Homo sapiens
6 ISG15 9636
Affinity Capture-MS Homo sapiens
7 SPECC1L 23384
Affinity Capture-MS Homo sapiens
8 PPP1CB 5500
Affinity Capture-MS Homo sapiens
9 Tpm1 22003
Affinity Capture-MS Mus musculus
10 SHC1 6464
Affinity Capture-Western Homo sapiens
11 POT1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
12 ARPC5L 81873
Affinity Capture-MS Homo sapiens
13 RPS4X 6191
Affinity Capture-MS Homo sapiens
14 ARPC2 10109
Affinity Capture-MS Homo sapiens
15 TOP2B 7155
Affinity Capture-MS Homo sapiens
16 ACTR2 10097
Affinity Capture-MS Homo sapiens
17 RPA2 6118
Affinity Capture-MS Homo sapiens
18 QKI 9444
Two-hybrid Homo sapiens
19 ACTC1 70
Proximity Label-MS Homo sapiens
20 PAICS 10606
Co-fractionation Homo sapiens
21 DYNC1I1  
Proximity Label-MS Homo sapiens
22 UQCRB 7381
Affinity Capture-MS Homo sapiens
23 SRGAP2 23380
Affinity Capture-MS Homo sapiens
24 CSNK2A1 1457
Co-fractionation Homo sapiens
25 CALM1 801
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
26 ANXA6 309
Affinity Capture-MS Homo sapiens
27 SYDE2  
Affinity Capture-MS Homo sapiens
28 PPP1CC 5501
Affinity Capture-MS Homo sapiens
29 KIAA1429 25962
Affinity Capture-MS Homo sapiens
30 POTEE 445582
Affinity Capture-MS Homo sapiens
31 WTAP 9589
Affinity Capture-MS Homo sapiens
32 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
33 RDX 5962
Proximity Label-MS Homo sapiens
34 PRR11  
Affinity Capture-MS Homo sapiens
35 STRN 6801
Affinity Capture-MS Homo sapiens
36 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
37 OTUB1 55611
Affinity Capture-MS Homo sapiens
38 MPP5 64398
Affinity Capture-MS Homo sapiens
39 DCTN4 51164
Proximity Label-MS Homo sapiens
40 ACTR3 10096
Affinity Capture-MS Homo sapiens
41 Poc1b  
Affinity Capture-MS Mus musculus
42 TM9SF4 9777
Affinity Capture-MS Homo sapiens
43 Pafah1b1 18472
Affinity Capture-MS Mus musculus
44 TINF2  
Two-hybrid Homo sapiens
45 PHLDB2 90102
Affinity Capture-MS Homo sapiens
46 STIP1 10963
Co-fractionation Homo sapiens
47 MYO1B 4430
Affinity Capture-MS Homo sapiens
48 PEAK1 79834
Affinity Capture-MS Homo sapiens
49 FIGNL1 63979
Affinity Capture-MS Homo sapiens
50 FAM107B 83641
Affinity Capture-MS Homo sapiens
51 KMT2A  
Cross-Linking-MS (XL-MS) Homo sapiens
52 FAM101B  
Affinity Capture-MS Homo sapiens
53 LMAN2 10960
Affinity Capture-MS Homo sapiens
54 ASF1A 25842
Affinity Capture-MS Homo sapiens
55 FAF2 23197
Cross-Linking-MS (XL-MS) Homo sapiens
56 TWF1 5756
Affinity Capture-MS Homo sapiens
57 TFRC 7037
Affinity Capture-MS Homo sapiens
58 SIK2  
Affinity Capture-MS Homo sapiens
59 PPP1CA 5499
Affinity Capture-MS Homo sapiens
60 NSUN2 54888
Affinity Capture-MS Homo sapiens
61 MYO18A 399687
Affinity Capture-MS Homo sapiens
62 UBN2  
Affinity Capture-MS Homo sapiens
63 SLC1A5 6510
Affinity Capture-MS Homo sapiens
64 DBNL 28988
Affinity Capture-MS Homo sapiens
65 CNOT2  
Affinity Capture-MS Homo sapiens
66 CABIN1  
Affinity Capture-MS Homo sapiens
67 CAPZA1 829
Affinity Capture-MS Homo sapiens
68 ITPR1 3708
Affinity Capture-MS Homo sapiens
69 LUZP1 7798
Affinity Capture-MS Homo sapiens
70 PPP1R9A  
Affinity Capture-MS Homo sapiens
71 PHAX  
Co-fractionation Homo sapiens
72 RAI14 26064
Affinity Capture-MS Homo sapiens
73 ACTR3B 57180
Affinity Capture-MS Homo sapiens
74 TMOD1  
Affinity Capture-MS Homo sapiens
75 EEF1G 1937
Cross-Linking-MS (XL-MS) Homo sapiens
76 FAM162A 26355
Affinity Capture-MS Homo sapiens
77 EFHD1  
Affinity Capture-MS Homo sapiens
78 CDH1 999
Proximity Label-MS Homo sapiens
79 BTF3 689
Affinity Capture-MS Homo sapiens
80 MYH9 4627
Affinity Capture-MS Homo sapiens
81 LRCH1 23143
Affinity Capture-MS Homo sapiens
82 ACTN4 81
Affinity Capture-MS Homo sapiens
83 NTRK1 4914
Affinity Capture-MS Homo sapiens
84 ARHGAP11A  
Affinity Capture-MS Homo sapiens
85 FLNB 2317
Affinity Capture-MS Homo sapiens
86 FH 2271
Co-fractionation Homo sapiens
87 ACTB 60
Proximity Label-MS Homo sapiens
88 Coro1c 23790
Affinity Capture-MS Mus musculus
89 ARPC5 10092
Affinity Capture-MS Homo sapiens
90 RPLP0 6175
Affinity Capture-MS Homo sapiens
91 MICAL3 57553
Cross-Linking-MS (XL-MS) Homo sapiens
92 ARPC1A 10552
Affinity Capture-MS Homo sapiens
93 DBN1 1627
Affinity Capture-MS Homo sapiens
94 ST13 6767
Cross-Linking-MS (XL-MS) Homo sapiens
95 LRCH3 84859
Affinity Capture-MS Homo sapiens
96 YWHAE 7531
Affinity Capture-MS Homo sapiens
97 LIMA1 51474
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 ACTN1 87
Co-fractionation Homo sapiens
99 TMPO 7112
Affinity Capture-MS Homo sapiens
100 ITPR2 3709
Affinity Capture-MS Homo sapiens
101 Myh9 17886
Affinity Capture-MS Mus musculus
102 ACTBL2 345651
Affinity Capture-MS Homo sapiens
103 METTL14  
Affinity Capture-MS Homo sapiens
104 DOCK8 81704
Affinity Capture-MS Homo sapiens
105 ARPC1B 10095
Affinity Capture-MS Homo sapiens
106 TPR 7175
Affinity Capture-MS Homo sapiens
107 PRRC2C 23215
Cross-Linking-MS (XL-MS) Homo sapiens
108 Plk2  
Affinity Capture-MS Mus musculus
109 TJP1 7082
Affinity Capture-MS Homo sapiens
110 VAMP3 9341
Affinity Capture-MS Homo sapiens
111 MYO1C 4641
Affinity Capture-MS Homo sapiens
112 CTTN 2017
Affinity Capture-MS Homo sapiens
113 PDIA3 2923
Co-fractionation Homo sapiens
114 SPECC1 92521
Affinity Capture-MS Homo sapiens
115 MYO19  
Affinity Capture-MS Homo sapiens
116 MTFR1  
Affinity Capture-MS Homo sapiens
117 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
118 MYO5C 55930
Affinity Capture-MS Homo sapiens
119 SPTBN1 6711
Affinity Capture-MS Homo sapiens
120 LMOD1 25802
Affinity Capture-MS Homo sapiens
121 FLNC 2318
Affinity Capture-MS Homo sapiens
122 PRKACA 5566
Biochemical Activity Homo sapiens
123 TJP2 9414
Affinity Capture-MS Homo sapiens
124 AIF1L 83543
Affinity Capture-MS Homo sapiens
125 MYC  
Affinity Capture-MS Homo sapiens
126 RPA3 6119
Affinity Capture-MS Homo sapiens
127 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
128 TMOD3 29766
Affinity Capture-MS Homo sapiens
129 AP2A2 161
Affinity Capture-MS Homo sapiens
130 NHP2L1 4809
Affinity Capture-MS Homo sapiens
131 RPL22 6146
Affinity Capture-MS Homo sapiens
132 CGN  
Affinity Capture-MS Homo sapiens
133 BICD1 636
Proximity Label-MS Homo sapiens
134 RPLP1 6176
Affinity Capture-MS Homo sapiens
135 FLII 2314
Affinity Capture-MS Homo sapiens
136 KIAA1671  
Affinity Capture-MS Homo sapiens
137 NDUFA3  
Affinity Capture-MS Homo sapiens
138 VDAC1 7416
Affinity Capture-MS Homo sapiens
139 MSN 4478
Co-fractionation Homo sapiens
140 Cep76  
Affinity Capture-MS Mus musculus
141 FLOT1 10211
Affinity Capture-MS Homo sapiens
142 PPME1 51400
Cross-Linking-MS (XL-MS) Homo sapiens
143 EIF3H 8667
Affinity Capture-MS Homo sapiens
144 TACC3  
Affinity Capture-MS Homo sapiens
145 LBR 3930
Two-hybrid Homo sapiens
146 ARPC3 10094
Affinity Capture-MS Homo sapiens
147 MTHFD2 10797
Affinity Capture-MS Homo sapiens
148 LAMB1 3912
Affinity Capture-MS Homo sapiens
149 NEXN 91624
Affinity Capture-MS Homo sapiens
150 SRRM1 10250
Cross-Linking-MS (XL-MS) Homo sapiens
151 SPTAN1 6709
Affinity Capture-MS Homo sapiens
152 TERF2  
Affinity Capture-MS Homo sapiens
153 PARP1 142
Proximity Label-MS Homo sapiens
154 SVIL 6840
Affinity Capture-MS Homo sapiens
155 SSFA2 6744
Affinity Capture-MS Homo sapiens
156 TP53 7157
Affinity Capture-MS Homo sapiens
157 SYAP1 94056
Cross-Linking-MS (XL-MS) Homo sapiens
158 SPTBN2 6712
Affinity Capture-MS Homo sapiens
159 EZR 7430
Proximity Label-MS Homo sapiens
160 RPA1 6117
Affinity Capture-MS Homo sapiens
161 SAP18 10284
Affinity Capture-MS Homo sapiens
162 ALDH1B1 219
Affinity Capture-MS Homo sapiens
163 SIPA1L3  
Affinity Capture-MS Homo sapiens
164 PDHA1 5160
Affinity Capture-MS Homo sapiens
165 CAPZA2 830
Affinity Capture-MS Homo sapiens
166 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
167 ITPR3 3710
Affinity Capture-MS Homo sapiens
168 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
170 Sass6  
Affinity Capture-MS Mus musculus
171 EPB41L2 2037
Co-fractionation Homo sapiens
172 AXIN1  
Cross-Linking-MS (XL-MS) Homo sapiens
173 RPS15A 6210
Affinity Capture-MS Homo sapiens
174 OAT 4942
Affinity Capture-MS Homo sapiens
175 TRAP1 10131
Affinity Capture-MS Homo sapiens
176 MPRIP 23164
Affinity Capture-MS Homo sapiens
177 KIF11 3832
Affinity Capture-MS Homo sapiens
178 RAB8A 4218
Cross-Linking-MS (XL-MS) Homo sapiens
179 RBFOX2 23543
Two-hybrid Homo sapiens
180 ANXA11 311
Affinity Capture-MS Homo sapiens
181 TERF1 7013
Two-hybrid Homo sapiens
182 GAPDH 2597
Co-fractionation Homo sapiens
183 HNRNPL 3191
Co-fractionation Homo sapiens
184 INF2 64423
Affinity Capture-MS Homo sapiens
185 Kif4  
Affinity Capture-MS Mus musculus
186 EEF1D 1936
Cross-Linking-MS (XL-MS) Homo sapiens
187 ARRB1 408
Affinity Capture-MS Homo sapiens
188 DAPK3 1613
Affinity Capture-MS Homo sapiens
189 FLNA 2316
Affinity Capture-MS Homo sapiens
190 ATP1A1 476
Affinity Capture-MS Homo sapiens
191 RPS7 6201
Affinity Capture-MS Homo sapiens
192 ANKRD11 29123
Cross-Linking-MS (XL-MS) Homo sapiens
193 RPL28 6158
Affinity Capture-MS Homo sapiens
194 HIRA  
Affinity Capture-MS Homo sapiens
195 CUL7 9820
Affinity Capture-MS Homo sapiens
196 BICD2 23299
Proximity Label-MS Homo sapiens
197 EIF3M 10480
Affinity Capture-MS Homo sapiens
198 LRP1 4035
Cross-Linking-MS (XL-MS) Homo sapiens
199 NEFM 4741
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
200 VIM 7431
Affinity Capture-MS Homo sapiens
201 ARPC4-TTLL3 100526693
Affinity Capture-MS Homo sapiens
202 NME1 4830
Co-fractionation Homo sapiens
203 IARS2 55699
Affinity Capture-MS Homo sapiens
204 ST13P5 144106
Cross-Linking-MS (XL-MS) Homo sapiens
205 OBSL1 23363
Affinity Capture-MS Homo sapiens
206 DYRK1A 1859
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CALD1 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Smooth Muscle Contraction TAS Reactome





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