Gene description for ARPC1A
Gene name actin related protein 2/3 complex, subunit 1A, 41kDa
Gene symbol ARPC1A
Other names/aliases Arc40
HEL-68
SOP2Hs
SOP2L
Species Homo sapiens
 Database cross references - ARPC1A
ExoCarta ExoCarta_10552
Entrez Gene 10552
HGNC 703
MIM 604220
UniProt Q92747  
 ARPC1A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for ARPC1A
Molecular Function
    actin binding GO:0003779 TAS
    actin filament binding GO:0051015 IBA
Biological Process
    Arp2/3 complex-mediated actin nucleation GO:0034314 IBA
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    ephrin receptor signaling pathway GO:0048013 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    axon guidance GO:0007411 TAS
    innate immune response GO:0045087 TAS
    actin cytoskeleton organization GO:0030036 TAS
Subcellular Localization
    actin cytoskeleton GO:0015629 TAS
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    Arp2/3 protein complex GO:0005885 IBA
 Experiment description of studies that identified ARPC1A in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ARPC1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTR3B 57180
Affinity Capture-MS Homo sapiens
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