Gene description for ACTR3B
Gene name ARP3 actin-related protein 3 homolog B (yeast)
Gene symbol ACTR3B
Other names/aliases ARP11
ARP3BETA
Species Homo sapiens
 Database cross references - ACTR3B
ExoCarta ExoCarta_57180
Entrez Gene 57180
HGNC 17256
UniProt Q9P1U1  
 ACTR3B identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
 Gene ontology annotations for ACTR3B
Molecular Function
    actin binding GO:0003779 IEA
    molecular_function GO:0003674 ND
    ATP binding GO:0005524 IEA
Biological Process
    Arp2/3 complex-mediated actin nucleation GO:0034314 IEA
    biological_process GO:0008150 ND
Subcellular Localization
    cytoplasm GO:0005737 IEA
    Arp2/3 protein complex GO:0005885 IEA
    extracellular exosome GO:0070062 IDA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified ACTR3B in exosomes
1
Experiment ID 139
ISEV standards
EM
EV Biophysical techniques
HSP70|HSP90|RAB5
EV Cytosolic markers
LAMP2|CD9
EV Membrane markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
2
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ACTR3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARPC4 10093
Affinity Capture-MS Homo sapiens
2 ACTR2 10097
Affinity Capture-MS Homo sapiens
3 ARPC3B  
Affinity Capture-MS Homo sapiens
4 ARPC5 10092
Affinity Capture-MS Homo sapiens
5 TWF2 11344
Affinity Capture-MS Homo sapiens
6 CDK4 1019
Affinity Capture-MS Homo sapiens
7 ARPC5L 81873
Affinity Capture-MS Homo sapiens
8 CCAR2 57805
Affinity Capture-MS Homo sapiens
9 ARPC1B 10095
Affinity Capture-MS Homo sapiens
10 ARPC2 10109
Affinity Capture-MS Homo sapiens
11 ARPC1A 10552
Affinity Capture-MS Homo sapiens
12 ARPC3 10094
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ACTR3B is involved
No pathways found





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