Gene description for ACTR3B
Gene name ARP3 actin-related protein 3 homolog B (yeast)
Gene symbol ACTR3B
Other names/aliases ARP11
ARP3BETA
Species Homo sapiens
 Database cross references - ACTR3B
ExoCarta ExoCarta_57180
Vesiclepedia VP_57180
Entrez Gene 57180
HGNC 17256
UniProt Q9P1U1  
 ACTR3B identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ACTR3B
Molecular Function
    ATP binding GO:0005524 IEA
    actin filament binding GO:0051015 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    cell projection GO:0042995 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ACTR3B in exosomes
1
Experiment ID 139
MISEV standards
EM
Biophysical techniques
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
HSP90B1
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
2
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
3
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ACTR3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARPC3 10094
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 OSBPL3 26031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TWF2 11344
Affinity Capture-MS Homo sapiens
4 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 EXOC5 10640
Two-hybrid Homo sapiens
6 ARPC5L 81873
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NDP  
Affinity Capture-MS Homo sapiens
8 ARPC1B 10095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ARPC2 10109
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ACTR2 10097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PDCL 5082
Affinity Capture-MS Homo sapiens
13 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ARPC4 10093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CHURC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TFAP4 7023
Affinity Capture-MS Homo sapiens
18 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ACTR3 10096
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
21 CCT8 10694
Affinity Capture-MS Homo sapiens
22 CCAR2 57805
Affinity Capture-MS Homo sapiens
23 ARPC3P1  
Affinity Capture-MS Homo sapiens
24 MSC  
Affinity Capture-MS Homo sapiens
25 SLC25A41  
Affinity Capture-MS Homo sapiens
26 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PUS7 54517
Affinity Capture-MS Homo sapiens
28 SEPT9 10801
Affinity Capture-MS Homo sapiens
29 XPO1 7514
Affinity Capture-MS Homo sapiens
30 CAPZB 832
Affinity Capture-MS Homo sapiens
31 C10orf88  
Affinity Capture-MS Homo sapiens
32 CMSS1  
Affinity Capture-MS Homo sapiens
33 ACADL 33
Affinity Capture-MS Homo sapiens
34 CDK4 1019
Affinity Capture-MS Homo sapiens
35 HMGN1  
Affinity Capture-MS Homo sapiens
36 MCM2 4171
Affinity Capture-MS Homo sapiens
37 RPS4Y1 6192
Affinity Capture-MS Homo sapiens
38 TUBD1  
Affinity Capture-MS Homo sapiens
39 SBNO1 55206
Affinity Capture-MS Homo sapiens
40 C14orf166 51637
Co-fractionation Homo sapiens
41 SERBP1 26135
Affinity Capture-MS Homo sapiens
42 CALD1 800
Affinity Capture-MS Homo sapiens
43 ENO1 2023
Affinity Capture-MS Homo sapiens
44 STK4 6789
Affinity Capture-MS Homo sapiens
45 ARPC5 10092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FAM133A 286499
Affinity Capture-MS Homo sapiens
47 ARPC1A 10552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KIF2C 11004
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ACTR3B is involved
No pathways found





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