Gene description for TFAP4
Gene name transcription factor AP-4 (activating enhancer binding protein 4)
Gene symbol TFAP4
Other names/aliases AP-4
bHLHc41
Species Homo sapiens
 Database cross references - TFAP4
ExoCarta ExoCarta_7023
Vesiclepedia VP_7023
Entrez Gene 7023
HGNC 11745
MIM 600743
UniProt Q01664  
 TFAP4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TFAP4
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
    histone deacetylase binding GO:0042826 IPI
    sequence-specific DNA binding GO:0043565 IDA
    E-box binding GO:0070888 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IDA
    negative regulation of cell population proliferation GO:0008285 IMP
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of DNA binding GO:0043392 IDA
    negative regulation by host of viral transcription GO:0043922 IDA
    negative regulation by host of viral transcription GO:0043922 NAS
    positive regulation by host of viral transcription GO:0043923 IDA
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    protein-containing complex assembly GO:0065003 IDA
    cellular response to dexamethasone stimulus GO:0071549 IEA
    regulation of mitotic cell cycle phase transition GO:1901990 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    transcription repressor complex GO:0017053 ISS
 Experiment description of studies that identified TFAP4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TFAP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NGEF  
Affinity Capture-MS Homo sapiens
2 NR2F6  
Affinity Capture-MS Homo sapiens
3 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 COIL  
Proximity Label-MS Homo sapiens
5 PRDM16 63976
Affinity Capture-MS Homo sapiens
6 Fbxw11  
Affinity Capture-MS Mus musculus
7 DNTTIP1 116092
Affinity Capture-MS Homo sapiens
8 HMGB1P10  
Affinity Capture-MS Homo sapiens
9 SP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 BRCA1 672
Affinity Capture-MS Homo sapiens
11 SMARCE1 6605
Affinity Capture-MS Homo sapiens
12 ZZZ3  
Affinity Capture-MS Homo sapiens
13 TERF2IP 54386
Affinity Capture-MS Homo sapiens
14 TRIB2 28951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SOX2  
Proximity Label-MS Homo sapiens
16 PAX6  
Proximity Label-MS Homo sapiens
17 APEX1 328
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
18 SRP54 6729
Co-fractionation Homo sapiens
19 SP3  
Affinity Capture-MS Homo sapiens
20 NR2F2  
Affinity Capture-MS Homo sapiens
21 C4orf27  
Affinity Capture-MS Homo sapiens
22 MDC1  
Affinity Capture-MS Homo sapiens
23 SOGA3  
Affinity Capture-MS Homo sapiens
24 TEAD1  
Proximity Label-MS Homo sapiens
25 USF2 7392
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
26 ELMSAN1  
Affinity Capture-MS Homo sapiens
27 INO80E  
Affinity Capture-MS Homo sapiens
28 CKAP5 9793
Affinity Capture-MS Homo sapiens
29 YEATS2  
Affinity Capture-MS Homo sapiens
30 BTAF1 9044
Affinity Capture-MS Homo sapiens
31 WIZ 58525
Affinity Capture-MS Homo sapiens
32 PPP6R3 55291
Affinity Capture-MS Homo sapiens
33 BTRC 8945
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PARP2  
Affinity Capture-MS Homo sapiens
35 SMARCB1 6598
Affinity Capture-MS Homo sapiens
36 MAD2L1 4085
Affinity Capture-MS Homo sapiens
37 ZNF462  
Affinity Capture-MS Homo sapiens
38 RBPJ 3516
Affinity Capture-MS Homo sapiens
39 Cebpb  
Affinity Capture-Western Rattus norvegicus
40 GTF2I 2969
Affinity Capture-MS Homo sapiens
41 KLF16  
Proximity Label-MS Homo sapiens
42 E2F4  
Affinity Capture-MS Homo sapiens
43 CLOCK  
Affinity Capture-MS Homo sapiens
44 S100A2 6273
Affinity Capture-MS Homo sapiens
45 UBN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FOXA1  
Affinity Capture-MS Homo sapiens
47 WDR45B 56270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
49 CABIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TFCP2 7024
Affinity Capture-MS Homo sapiens
51 CTBP1 1487
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
52 NFIX 4784
Proximity Label-MS Homo sapiens
53 GOLGA2 2801
Two-hybrid Homo sapiens
54 SNRNP200 23020
Co-fractionation Homo sapiens
55 VRK1 7443
Affinity Capture-MS Homo sapiens
56 ANGPTL7 10218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ZHX3  
Affinity Capture-MS Homo sapiens
58 ACTR3B 57180
Affinity Capture-MS Homo sapiens
59 NFIA 4774
Affinity Capture-MS Homo sapiens
60 RAN 5901
Affinity Capture-MS Homo sapiens
61 ESRRA  
Affinity Capture-MS Homo sapiens
62 FOXK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 BPTF 2186
Co-fractionation Homo sapiens
64 SIN3A  
Affinity Capture-MS Homo sapiens
65 UBP1 7342
Affinity Capture-MS Homo sapiens
66 MBD2 8932
Affinity Capture-MS Homo sapiens
67 DDX39B 7919
Affinity Capture-MS Homo sapiens
68 KCTD17 79734
Affinity Capture-MS Homo sapiens
69 CEBPA  
Proximity Label-MS Homo sapiens
70 KCTD2  
Affinity Capture-MS Homo sapiens
71 HMGB2 3148
Affinity Capture-MS Homo sapiens
72 SMARCC2 6601
Affinity Capture-MS Homo sapiens
73 BRD7  
Affinity Capture-MS Homo sapiens
74 Cdkn2aip  
Affinity Capture-MS Mus musculus
75 CHRAC1  
Affinity Capture-MS Homo sapiens
76 ADAMTS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 AIM2  
Affinity Capture-MS Homo sapiens
78 POLE2  
Affinity Capture-MS Homo sapiens
79 GNB4 59345
Affinity Capture-MS Homo sapiens
80 TLX1  
Proximity Label-MS Homo sapiens
81 CTC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 THYN1 29087
Affinity Capture-MS Homo sapiens
83 S100A8 6279
Affinity Capture-MS Homo sapiens
84 UHRF2  
Affinity Capture-MS Homo sapiens
85 OBFC1 79991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 BAP1 8314
Negative Genetic Homo sapiens
87 TTF2 8458
Affinity Capture-MS Homo sapiens
88 CUL1 8454
Affinity Capture-MS Homo sapiens
89 SIN3B  
Affinity Capture-MS Homo sapiens
90 PKNOX1  
Affinity Capture-MS Homo sapiens
91 SOX15  
Proximity Label-MS Homo sapiens
92 FASN 2194
Negative Genetic Homo sapiens
93 HMGB3 3149
Affinity Capture-MS Homo sapiens
94 ATF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 NEU2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 EHMT2 10919
Affinity Capture-MS Homo sapiens
97 ZBTB7B  
Affinity Capture-MS Homo sapiens
98 TCEB2 6923
Affinity Capture-MS Homo sapiens
99 ARID1A 8289
Affinity Capture-MS Homo sapiens
100 NR2F1  
Affinity Capture-MS Homo sapiens
101 NFATC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
102 PYHIN1  
Affinity Capture-MS Homo sapiens
103 XRCC5 7520
Co-fractionation Homo sapiens
104 Kctd5  
Affinity Capture-MS Mus musculus
105 SLC25A43  
Affinity Capture-MS Homo sapiens
106 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 CTCF  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
108 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 TERF2  
Affinity Capture-MS Homo sapiens
110 TP53 7157
Affinity Capture-Western Homo sapiens
111 ARID2  
Affinity Capture-MS Homo sapiens
112 TOPBP1 11073
Affinity Capture-MS Homo sapiens
113 HMGB1 3146
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
114 SAP130  
Affinity Capture-MS Homo sapiens
115 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 FBXO38 81545
Proximity Label-MS Homo sapiens
117 EFNB1 1947
Affinity Capture-MS Homo sapiens
118 ZNF335 63925
Affinity Capture-MS Homo sapiens
119 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
120 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
121 PDE9A  
Two-hybrid Homo sapiens
122 NAV3 89795
Affinity Capture-MS Homo sapiens
123 RAD50 10111
Affinity Capture-MS Homo sapiens
124 PCNA 5111
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
125 FOXK1 221937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 TFCP2L1  
Affinity Capture-MS Homo sapiens
127 PRKCA 5578
Affinity Capture-MS Homo sapiens
128 MTA3 57504
Affinity Capture-MS Homo sapiens
129 EHMT1  
Affinity Capture-MS Homo sapiens
130 HIRA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 NFIC 4782
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 FOXE1  
Affinity Capture-MS Homo sapiens
133 ZBTB7A 51341
Affinity Capture-MS Homo sapiens
134 EXOSC8  
Two-hybrid Homo sapiens
135 TRAF1 7185
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TFAP4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here