Gene description for SMARCC2
Gene name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Gene symbol
SMARCC2
Other names/aliases
BAF170 CRACC2 Rsc8
Species
Homo sapiens
Database cross references - SMARCC2
ExoCarta
ExoCarta_6601
Entrez Gene
6601
HGNC
11105
MIM
601734
UniProt
Q8TAQ2
SMARCC2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells
25944692
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Thymus
23844026
Gene ontology annotations for SMARCC2
Experiment description of studies that identified SMARCC2 in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
4
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for SMARCC2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
GATA1
Reconstituted Complex
Homo sapiens
2
POLR2C
5432
Two-hybrid
Homo sapiens
3
PEX14
Two-hybrid
Homo sapiens
4
SMARCB1
6598
Co-purification
Homo sapiens
5
ITSN1
6453
Two-hybrid
Homo sapiens
6
STAT2
6773
Affinity Capture-Western
Homo sapiens
7
KLF1
Reconstituted Complex
Homo sapiens
8
BAZ1B
9031
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
9
SMARCD1
6602
Affinity Capture-Western
Homo sapiens
10
SP1
Reconstituted Complex
Homo sapiens
11
BRCA1
672
Co-purification
Homo sapiens
12
SMARCE1
6605
Affinity Capture-Western
Homo sapiens
13
ARRB2
Two-hybrid
Homo sapiens
14
HSP90B1
7184
Affinity Capture-Western
Homo sapiens
15
SMARCA2
Co-purification
Homo sapiens
16
SMARCA4
6597
Co-purification
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
17
NCOR1
Co-purification
Homo sapiens
18
PHYHIP
9796
Two-hybrid
Homo sapiens
19
CDK8
Co-fractionation
Homo sapiens
20
ING1
Affinity Capture-MS
Homo sapiens
21
RELB
Affinity Capture-MS
Homo sapiens
22
ACTB
60
Affinity Capture-Western
Homo sapiens
View the network
image/svg+xml
Pathways in which SMARCC2 is involved