Gene description for APEX1
Gene name	APEX nuclease (multifunctional DNA repair enzyme) 1
Gene symbol	APEX1
Other names/aliases	APE APE1 APEN APEX APX HAP1 REF1
Species	Homo sapiens
Database cross references - APEX1
ExoCarta	ExoCarta_328
Entrez Gene	328
HGNC	587
MIM	107748
UniProt	P27695
APEX1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for APEX1

Molecular Function     phosphoric diester hydrolase activity GO:0008081 IDA     uracil DNA N-glycosylase activity GO:0004844 TAS     site-specific endodeoxyribonuclease activity, specific for altered base GO:0016890 IDA     poly(A) RNA binding GO:0044822 IDA     DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 TAS     endonuclease activity GO:0004519 IDA     RNA-DNA hybrid ribonuclease activity GO:0004523 TAS     NF-kappaB binding GO:0051059 IEA     DNA binding GO:0003677 IDA     protein complex binding GO:0032403 IEA     transcription coactivator activity GO:0003713 IDA     phosphodiesterase I activity GO:0004528 TAS     oxidoreductase activity GO:0016491 IDA     chromatin DNA binding GO:0031490 IDA     endodeoxyribonuclease activity GO:0004520 TAS     protein binding GO:0005515 IPI     3'-5' exonuclease activity GO:0008408 TAS     metal ion binding GO:0046872 IDA     damaged DNA binding GO:0003684 IDA     double-stranded DNA 3'-5' exodeoxyribonuclease activity GO:0008311 IBA     transcription corepressor activity GO:0003714 TAS Biological Process     transcription, DNA-templated GO:0006351 IEA     mitotic cell cycle GO:0000278 TAS     positive regulation of DNA repair GO:0045739 IDA     transcription-coupled nucleotide-excision repair GO:0006283 TAS     DNA strand elongation involved in DNA replication GO:0006271 TAS     nucleotide-excision repair GO:0006289 TAS     negative regulation of nucleic acid-templated transcription GO:1903507 TAS     DNA repair GO:0006281 TAS     regulation of mRNA stability GO:0043488 IMP     telomere maintenance GO:0000723 TAS     double-strand break repair via homologous recombination GO:0000724 TAS     telomere maintenance via semi-conservative replication GO:0032201 TAS     cell redox homeostasis GO:0045454 IEA     cellular response to cAMP GO:0071320 IEA     oxidation-reduction process GO:0055114 IDA     regulation of transcription, DNA-templated GO:0006355 IEA     response to drug GO:0042493 IEA     cellular response to peptide hormone stimulus GO:0071375 IEA     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA     base-excision repair GO:0006284 TAS     nucleotide-excision repair, DNA gap filling GO:0006297 TAS     telomere maintenance via recombination GO:0000722 TAS     aging GO:0007568 IEA     negative regulation of smooth muscle cell migration GO:0014912 IEA     RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IEA     DNA demethylation GO:0080111 IDA     cellular response to hydrogen peroxide GO:0070301 IEA     mismatch repair GO:0006298 TAS     double-strand break repair GO:0006302 TAS Subcellular Localization     transcription factor complex GO:0005667 IEA     nucleoplasm GO:0005654 TAS     perinuclear region of cytoplasm GO:0048471 IDA     mitochondrion GO:0005739 IDA     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IDA     ribosome GO:0005840 TAS     nuclear speck GO:0016607 IDA     nucleus GO:0005634 IDA     endoplasmic reticulum GO:0005783 TAS     centrosome GO:0005813 IDA