Gene description for HMGB2
Gene name	high mobility group box 2
Gene symbol	HMGB2
Other names/aliases	HMG2
Species	Homo sapiens
Database cross references - HMGB2
ExoCarta	ExoCarta_3148
Entrez Gene	3148
HGNC	5000
MIM	163906
UniProt	P26583
HMGB2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for HMGB2

Molecular Function     chemoattractant activity GO:0042056 IDA     damaged DNA binding GO:0003684 IDA     RAGE receptor binding GO:0050786 IGI     double-stranded DNA binding GO:0003690 ISS     DNA binding, bending GO:0008301 IDA     DNA binding GO:0003677 IMP     single-stranded DNA binding GO:0003697 ISS     transcription regulatory region DNA binding GO:0044212 IDA     protein domain specific binding GO:0019904 IEA     poly(A) RNA binding GO:0044822 IDA     chromatin binding GO:0003682 IBA     protein binding GO:0005515 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 IDA Biological Process     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     chromatin organization GO:0006325 NAS     cellular response to lipopolysaccharide GO:0071222 IEP     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA     positive regulation of megakaryocyte differentiation GO:0045654 IMP     base-excision repair, DNA ligation GO:0006288 IDA     positive regulation of nuclease activity GO:0032075 IDA     response to steroid hormone GO:0048545 IEA     programmed cell death GO:0012501 TAS     chromatin remodeling GO:0006338 IBA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     apoptotic DNA fragmentation GO:0006309 TAS     positive regulation of transcription, DNA-templated GO:0045893 IDA     negative regulation of transcription, DNA-templated GO:0045892 IDA     DNA ligation involved in DNA repair GO:0051103 ISS     V(D)J recombination GO:0033151 ISS     positive regulation of erythrocyte differentiation GO:0045648 IMP     positive regulation of DNA binding GO:0043388 IDA     male gonad development GO:0008584 IEA     spermatid nucleus differentiation GO:0007289 IEA     nucleosome assembly GO:0006334 NAS     positive regulation of endothelial cell proliferation GO:0001938 IDA     positive chemotaxis GO:0050918 IDA     cell chemotaxis GO:0060326 IDA     regulation of transcription from RNA polymerase II promoter GO:0006357 IDA     DNA topological change GO:0006265 ISS     apoptotic process GO:0006915 TAS Subcellular Localization     condensed chromosome GO:0000793 IDA     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     extracellular space GO:0005615 IDA     perinuclear region of cytoplasm GO:0048471 IDA     protein complex GO:0043234 IDA