Gene description for POU2F2
Gene name POU class 2 homeobox 2
Gene symbol POU2F2
Other names/aliases OCT2
OTF2
Oct-2
Species Homo sapiens
 Database cross references - POU2F2
ExoCarta ExoCarta_5452
Vesiclepedia VP_5452
Entrez Gene 5452
HGNC 9213
MIM 164176
UniProt P09086  
 POU2F2 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for POU2F2
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISS
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription factor activity GO:0003700 ISS
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    humoral immune response GO:0006959 TAS
    positive regulation of interleukin-6 production GO:0032755 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    cellular response to virus GO:0098586 ISS
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified POU2F2 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POU2F2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOXJ2  
Affinity Capture-MS Homo sapiens
2 XRCC6 2547
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 ESR1  
Reconstituted Complex Homo sapiens
4 TBP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 TXNRD1 7296
Reconstituted Complex Homo sapiens
6 POU2F2 5452
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
7 NR3C1 2908
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 GAPDH 2597
Reconstituted Complex Homo sapiens
9 HMGA1 3159
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
10 MNAT1  
Reconstituted Complex Homo sapiens
11 AR 367
Reconstituted Complex Homo sapiens
12 PGR  
Reconstituted Complex Homo sapiens
13 RXRA 6256
Reconstituted Complex Homo sapiens
14 FOXS1  
Affinity Capture-MS Homo sapiens
15 AQP3  
Affinity Capture-MS Homo sapiens
16 TMEM108  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FAM49B 51571
Affinity Capture-MS Homo sapiens
18 HMGB2 3148
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
19 FOXC2  
Affinity Capture-MS Homo sapiens
20 TEAD2  
Affinity Capture-MS Homo sapiens
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