Gene description for RPS27L
Gene name ribosomal protein S27-like
Gene symbol RPS27L
Other names/aliases -
Species Homo sapiens
 Database cross references - RPS27L
ExoCarta ExoCarta_51065
Entrez Gene 51065
HGNC 18476
MIM 612055
UniProt Q71UM5  
 RPS27L identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for RPS27L
Molecular Function
    cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 IDA
    translation activator activity GO:0008494 IDA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    structural constituent of ribosome GO:0003735 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    mitotic G1 DNA damage checkpoint GO:0031571 IMP
    cellular response to DNA damage stimulus GO:0006974 IDA
    translation GO:0006412 IDA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IDA
    positive regulation of translation GO:0045727 IDA
    DNA repair GO:0006281 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    ribosome GO:0005840 IEA
 Experiment description of studies that identified RPS27L in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RPS27L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RPS27L is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here