Gene description for EIF4ENIF1
Gene name eukaryotic translation initiation factor 4E nuclear import factor 1
Gene symbol EIF4ENIF1
Other names/aliases 4E-T
Species Homo sapiens
 Database cross references - EIF4ENIF1
ExoCarta ExoCarta_56478
Entrez Gene 56478
HGNC 16687
MIM 607445
UniProt Q9NRA8  
 EIF4ENIF1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for EIF4ENIF1
Molecular Function
    protein binding GO:0005515 IPI
    protein transporter activity GO:0008565 TAS
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    protein transport GO:0015031 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    membrane GO:0016020 IDA
    nucleus GO:0005634 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    nuclear speck GO:0016607 IEA
    cytoplasm GO:0005737 TAS
    PML body GO:0016605 IEA
 Experiment description of studies that identified EIF4ENIF1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for EIF4ENIF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF4E 1977
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 SMAD3  
Affinity Capture-MS Homo sapiens
3 EIF4E2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which EIF4ENIF1 is involved
No pathways found

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