Gene description for PHIP
Gene name pleckstrin homology domain interacting protein
Gene symbol PHIP
Other names/aliases BRWD2
DCAF14
WDR11
ndrp
Species Homo sapiens
 Database cross references - PHIP
ExoCarta ExoCarta_55023
Vesiclepedia VP_55023
Entrez Gene 55023
HGNC 15673
MIM 612870
UniProt Q8WWQ0  
 PHIP identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for PHIP
Molecular Function
    insulin receptor binding GO:0005158 NAS
    protein binding GO:0005515 IPI
    lysine-acetylated histone binding GO:0070577 IDA
Biological Process
    regulation of protein phosphorylation GO:0001932 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    cytoskeleton organization GO:0007010 IBA
    cytoskeleton organization GO:0007010 IMP
    positive regulation of cell population proliferation GO:0008284 ISS
    insulin receptor signaling pathway GO:0008286 NAS
    regulation of cell shape GO:0008360 IBA
    regulation of cell morphogenesis GO:0022604 IMP
    negative regulation of apoptotic process GO:0043066 ISS
    positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 ISS
    positive regulation of mitotic nuclear division GO:0045840 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified PHIP in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for PHIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 ZFHX3  
Affinity Capture-MS Homo sapiens
4 ZFHX4  
Affinity Capture-MS Homo sapiens
5 EGR1  
Affinity Capture-MS Homo sapiens
6 Brwd3  
Affinity Capture-MS Mus musculus
7 PKP2 5318
Affinity Capture-MS Homo sapiens
8 STMN4  
Two-hybrid Homo sapiens
9 CEP170 9859
Affinity Capture-MS Homo sapiens
10 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
11 ZNF608  
Affinity Capture-MS Homo sapiens
12 SMG7  
Affinity Capture-MS Homo sapiens
13 RPL10 6134
Affinity Capture-MS Homo sapiens
14 CHCHD1  
Proximity Label-MS Homo sapiens
15 BRD2  
Affinity Capture-MS Homo sapiens
16 TAF1  
Affinity Capture-MS Homo sapiens
17 AKAP8L  
Affinity Capture-MS Homo sapiens
18 TAF5  
Affinity Capture-MS Homo sapiens
19 CENPA  
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
20 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
21 EIF4ENIF1 56478
Affinity Capture-MS Homo sapiens
22 WDR76  
Affinity Capture-MS Homo sapiens
23 TNRC6A 27327
Affinity Capture-MS Homo sapiens
24 GSE1 23199
Affinity Capture-MS Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 TCF12  
Affinity Capture-MS Homo sapiens
27 HELZ 9931
Affinity Capture-MS Homo sapiens
28 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
29 BRWD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PRC1 9055
Affinity Capture-MS Homo sapiens
31 AGO3  
Affinity Capture-MS Homo sapiens
32 FBL 2091
Proximity Label-MS Homo sapiens
33 OBSL1 23363
Affinity Capture-MS Homo sapiens
34 HMGA1 3159
Affinity Capture-MS Homo sapiens
35 BRD4 23476
Affinity Capture-MS Homo sapiens
36 INTS6 26512
Affinity Capture-MS Homo sapiens
37 BCOR  
Affinity Capture-MS Homo sapiens
38 ADCK3  
Affinity Capture-MS Homo sapiens
39 FOXP2 93986
Affinity Capture-MS Homo sapiens
40 NCK1 4690
Affinity Capture-MS Homo sapiens
41 RCOR3  
Affinity Capture-MS Homo sapiens
42 FAM120A 23196
Affinity Capture-MS Homo sapiens
43 BCL11B  
Affinity Capture-MS Homo sapiens
44 KIF14 9928
Affinity Capture-MS Homo sapiens
45 LARP4B 23185
Affinity Capture-MS Homo sapiens
46 FOXP1 27086
Affinity Capture-MS Homo sapiens
47 AGO2 27161
Affinity Capture-MS Homo sapiens
48 CHMP4C 92421
Affinity Capture-MS Homo sapiens
49 ZIC2  
Affinity Capture-MS Homo sapiens
50 FOXP4  
Affinity Capture-MS Homo sapiens
51 IRAK1  
Affinity Capture-MS Homo sapiens
52 ANKRD17 26057
Affinity Capture-MS Homo sapiens
53 CLU 1191
Affinity Capture-MS Homo sapiens
54 NCOR2  
Affinity Capture-MS Homo sapiens
55 XRN1 54464
Affinity Capture-MS Homo sapiens
56 LYN 4067
Proximity Label-MS Homo sapiens
57 CBX3 11335
Proximity Label-MS Homo sapiens
58 VRK1 7443
Affinity Capture-MS Homo sapiens
59 PRDM16 63976
Affinity Capture-MS Homo sapiens
60 ANKHD1 54882
Affinity Capture-MS Homo sapiens
61 RPA2 6118
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
62 NKRF 55922
Affinity Capture-MS Homo sapiens
63 GLI3 2737
Affinity Capture-MS Homo sapiens
64 IFI16 3428
Affinity Capture-MS Homo sapiens
65 OPA1 4976
Affinity Capture-MS Homo sapiens
66 TRIM66  
Affinity Capture-MS Homo sapiens
67 PML 5371
Affinity Capture-MS Homo sapiens
68 SOWAHA  
Affinity Capture-MS Homo sapiens
69 DBT 1629
Affinity Capture-MS Homo sapiens
70 SOWAHC  
Affinity Capture-MS Homo sapiens
71 NECAP1 25977
Affinity Capture-MS Homo sapiens
72 ZCCHC11 23318
Affinity Capture-MS Homo sapiens
73 ZNF609  
Affinity Capture-MS Homo sapiens
74 CD3EAP  
Proximity Label-MS Homo sapiens
75 ANLN 54443
Affinity Capture-MS Homo sapiens
76 NUMA1 4926
Affinity Capture-MS Homo sapiens
77 TMPO 7112
Affinity Capture-MS Homo sapiens
78 ZBTB2 57621
Affinity Capture-MS Homo sapiens
79 HIST1H3A 8350
Proximity Label-MS Homo sapiens
80 TAF3 83860
Affinity Capture-MS Homo sapiens
81 RERE 473
Affinity Capture-MS Homo sapiens
82 CECR2  
Affinity Capture-MS Homo sapiens
83 SIRT7  
Affinity Capture-MS Homo sapiens
84 UBXN7 26043
Affinity Capture-MS Homo sapiens
85 CPEB4  
Affinity Capture-MS Homo sapiens
86 GCDH 2639
Affinity Capture-MS Homo sapiens
87 ACAD11 84129
Affinity Capture-MS Homo sapiens
88 CUL3 8452
Affinity Capture-MS Homo sapiens
89 RICTOR 253260
Affinity Capture-MS Homo sapiens
90 TNRC6B  
Affinity Capture-MS Homo sapiens
91 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
92 RPA3 6119
Proximity Label-MS Homo sapiens
93 PYHIN1  
Affinity Capture-MS Homo sapiens
94 MYEF2 50804
Affinity Capture-MS Homo sapiens
95 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 RNF2  
Affinity Capture-MS Homo sapiens
97 MECOM 2122
Affinity Capture-MS Homo sapiens
98 Eif3e 16341
Affinity Capture-MS Mus musculus
99 MCM3AP  
Affinity Capture-MS Homo sapiens
100 Cul4a  
Affinity Capture-MS Mus musculus
101 BRD3 8019
Affinity Capture-MS Homo sapiens
102 SUPT16H 11198
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
103 TAF4 6874
Affinity Capture-MS Homo sapiens
104 Cbx1  
Affinity Capture-MS Mus musculus
105 TAF6 6878
Affinity Capture-MS Homo sapiens
106 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
107 MKRN1 23608
Affinity Capture-MS Homo sapiens
108 PARP1 142
Proximity Label-MS Homo sapiens
109 TRPS1  
Affinity Capture-MS Homo sapiens
110 NUCKS1 64710
Affinity Capture-MS Homo sapiens
111 HDAC6 10013
Affinity Capture-MS Homo sapiens
112 BCKDHA 593
Affinity Capture-MS Homo sapiens
113 HMGN5 79366
Affinity Capture-MS Homo sapiens
114 Atrx  
Affinity Capture-MS Mus musculus
115 TUBB3 10381
Two-hybrid Homo sapiens
116 ZNF536  
Affinity Capture-MS Homo sapiens
117 ASS1 445
Affinity Capture-MS Homo sapiens
118 Chaf1a  
Affinity Capture-MS Mus musculus
119 TAF2  
Affinity Capture-MS Homo sapiens
120 ZNF281  
Affinity Capture-MS Homo sapiens
121 FAM120C 54954
Affinity Capture-MS Homo sapiens
122 TBK1 29110
Affinity Capture-MS Homo sapiens
123 NUP50 10762
Proximity Label-MS Homo sapiens
124 FECH 2235
Affinity Capture-MS Homo sapiens
125 RPS6 6194
Proximity Label-MS Homo sapiens
126 ORC1  
Affinity Capture-MS Homo sapiens
127 CUL7 9820
Affinity Capture-MS Homo sapiens
128 CIZ1  
Affinity Capture-MS Homo sapiens
129 DIAPH1 1729
Affinity Capture-MS Homo sapiens
130 SSRP1 6749
Affinity Capture-MS Homo sapiens
131 RCOR1  
Affinity Capture-MS Homo sapiens
132 KIAA0355 9710
Affinity Capture-MS Homo sapiens
133 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
134 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
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