Gene description for PHIP
Gene name pleckstrin homology domain interacting protein
Gene symbol PHIP
Other names/aliases BRWD2
Species Homo sapiens
 Database cross references - PHIP
ExoCarta ExoCarta_55023
Entrez Gene 55023
HGNC 15673
MIM 612870
UniProt Q8WWQ0  
 PHIP identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for PHIP
Molecular Function
    protein binding GO:0005515 IPI
    lysine-acetylated histone binding GO:0070577 IDA
    insulin receptor binding GO:0005158 NAS
Biological Process
    regulation of protein phosphorylation GO:0001932 ISS
    negative regulation of apoptotic process GO:0043066 ISS
    regulation of growth GO:0040008 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IDA
    regulation of cell morphogenesis GO:0022604 IMP
    positive regulation of cell proliferation GO:0008284 ISS
    positive regulation of mitotic nuclear division GO:0045840 ISS
    positive regulation of peptidyl-threonine phosphorylation GO:0010800 IEA
    positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 ISS
    cytoskeleton organization GO:0007010 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    protein import into nucleus GO:0006606 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    insulin receptor signaling pathway GO:0008286 NAS
    regulation of cell shape GO:0008360 IBA
    positive regulation of transcription, DNA-templated GO:0045893 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified PHIP in exosomes
Experiment ID 226
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for PHIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STMN4  
Two-hybrid Homo sapiens
2 IRS1 3667
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 TUBB3 10381
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PHIP is involved
No pathways found

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