Gene description for FOXP1
Gene name forkhead box P1
Gene symbol FOXP1
Other names/aliases 12CC4
HSPC215
MFH
QRF1
hFKH1B
Species Homo sapiens
 Database cross references - FOXP1
ExoCarta ExoCarta_27086
Vesiclepedia VP_27086
Entrez Gene 27086
HGNC 3823
MIM 605515
UniProt Q9H334  
 FOXP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FOXP1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    core promoter sequence-specific DNA binding GO:0001046 IDA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
    nuclear androgen receptor binding GO:0050681 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of B cell apoptotic process GO:0002903 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    DNA damage response GO:0006974 IMP
    regulation of gene expression GO:0010468 IMP
    positive regulation of endothelial cell migration GO:0010595 IMP
    negative regulation of gene expression GO:0010629 IDA
    striatum development GO:0021756 IEA
    osteoclast differentiation GO:0030316 IDA
    response to lipopolysaccharide GO:0032496 IDA
    regulation of interleukin-1 beta production GO:0032651 IDA
    regulation of interleukin-12 production GO:0032655 IDA
    regulation of tumor necrosis factor production GO:0032680 IDA
    positive regulation of interleukin-21 production GO:0032745 ISS
    response to testosterone GO:0033574 IEA
    osteoclast development GO:0036035 IDA
    macrophage activation GO:0042116 IDA
    monocyte activation GO:0042117 IDA
    endothelial cell activation GO:0042118 IMP
    regulation of monocyte differentiation GO:0045655 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of smooth muscle cell proliferation GO:0048661 IMP
    regulation of inflammatory response GO:0050727 IDA
    positive regulation of B cell receptor signaling pathway GO:0050861 IMP
    negative regulation of androgen receptor signaling pathway GO:0060766 IDA
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 IEA
    T follicular helper cell differentiation GO:0061470 ISS
    cellular response to tumor necrosis factor GO:0071356 IEA
    regulation of defense response to bacterium GO:1900424 IDA
    regulation of macrophage colony-stimulating factor production GO:1901256 IDA
    positive regulation of hydrogen peroxide-mediated programmed cell death GO:1901300 IEA
    regulation of endothelial tube morphogenesis GO:1901509 IMP
    regulation of chemokine (C-X-C motif) ligand 2 production GO:2000341 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified FOXP1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FOXP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Protein-RNA Homo sapiens
2 FOXF1 2294
Affinity Capture-MS Homo sapiens
3 LDHA 3939
Co-localization Homo sapiens
4 TUBA8 51807
Protein-RNA Homo sapiens
5 GATAD2B 57459
Affinity Capture-Western Homo sapiens
6 SNRPE 6635
Protein-RNA Homo sapiens
7 FEV  
Proximity Label-MS Homo sapiens
8 NFIB  
Proximity Label-MS Homo sapiens
9 BAZ2B  
Protein-RNA Homo sapiens
10 PKM 5315
Co-localization Homo sapiens
11 CTBP2 1488
Affinity Capture-MS Homo sapiens
12 LHX2  
Proximity Label-MS Homo sapiens
13 STRAP 11171
Protein-RNA Homo sapiens
14 GATA2  
Proximity Label-MS Homo sapiens
15 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PAX2  
Proximity Label-MS Homo sapiens
17 DDX19B 11269
Protein-RNA Homo sapiens
18 SASH1 23328
Co-fractionation Homo sapiens
19 PFKM 5213
Co-localization Homo sapiens
20 CLTB 1212
Co-fractionation Homo sapiens
21 TAF1  
Affinity Capture-MS Homo sapiens
22 SNRPF 6636
Protein-RNA Homo sapiens
23 SOX2  
Proximity Label-MS Homo sapiens
24 KIF27  
Protein-RNA Homo sapiens
25 RPS3 6188
Protein-RNA Homo sapiens
26 SATB2  
Affinity Capture-MS Homo sapiens
27 RGL1  
Protein-RNA Homo sapiens
28 XRCC1 7515
Affinity Capture-MS Homo sapiens
29 TOP2A 7153
Affinity Capture-MS Homo sapiens
30 RPS20 6224
Protein-RNA Homo sapiens
31 IGF2BP3 10643
Protein-RNA Homo sapiens
32 SNRNP70 6625
Affinity Capture-MS Homo sapiens
33 PDK1 5163
Co-localization Homo sapiens
34 HIST3H2A 92815
Protein-RNA Homo sapiens
35 KLF8  
Proximity Label-MS Homo sapiens
36 TBC1D23 55773
Protein-RNA Homo sapiens
37 CUX1 1523
Affinity Capture-MS Homo sapiens
38 SNRPC 6631
Protein-RNA Homo sapiens
39 GCM1  
Proximity Label-MS Homo sapiens
40 DMD 1756
Protein-RNA Homo sapiens
41 SRP14 6727
Protein-RNA Homo sapiens
42 TEAD1  
Proximity Label-MS Homo sapiens
43 STAU2 27067
Protein-RNA Homo sapiens
44 TNFRSF1B  
Protein-RNA Homo sapiens
45 UGGT1 56886
Protein-RNA Homo sapiens
46 RCC1 1104
Affinity Capture-MS Homo sapiens
47 SSBP1 6742
Protein-RNA Homo sapiens
48 TFCP2 7024
Affinity Capture-MS Homo sapiens
49 ECE2  
Protein-RNA Homo sapiens
50 FOXP2 93986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
51 DLAT 1737
Protein-RNA Homo sapiens
52 SOX5 6660
Proximity Label-MS Homo sapiens
53 FOXP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 GAR1 54433
Protein-RNA Homo sapiens
55 HSPA8 3312
Protein-RNA Homo sapiens
56 FOXP1 27086
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 MYL9 10398
Affinity Capture-MS Homo sapiens
58 KLF16  
Proximity Label-MS Homo sapiens
59 NUP62CL  
Affinity Capture-MS Homo sapiens
60 RPL27 6155
Protein-RNA Homo sapiens
61 VRK3 51231
Affinity Capture-MS Homo sapiens
62 CDKN2AIP  
Protein-RNA Homo sapiens
63 PRDM1  
Proximity Label-MS Homo sapiens
64 TYW1B  
Protein-RNA Homo sapiens
65 TLX3  
Proximity Label-MS Homo sapiens
66 MRE11A 4361
Affinity Capture-MS Homo sapiens
67 EXOG 9941
Protein-RNA Homo sapiens
68 RPL4 6124
Protein-RNA Homo sapiens
69 ALB 213
Protein-RNA Homo sapiens
70 CTBP1 1487
Affinity Capture-Western Homo sapiens
71 TARBP2  
Protein-RNA Homo sapiens
72 IGH 3492
Affinity Capture-MS Homo sapiens
73 NCOR2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
74 SRSF3 6428
Protein-RNA Homo sapiens
75 BLM 641
Affinity Capture-MS Homo sapiens
76 STAU1 6780
Protein-RNA Homo sapiens
77 NFIX 4784
Proximity Label-MS Homo sapiens
78 GOLGA2 2801
Protein-RNA Homo sapiens
79 RPL5 6125
Protein-RNA Homo sapiens
80 NFIA 4774
Proximity Label-MS Homo sapiens
81 TUBA1B 10376
Protein-RNA Homo sapiens
82 RPA2 6118
Affinity Capture-MS Homo sapiens
83 WDR72  
Protein-RNA Homo sapiens
84 RAN 5901
Protein-RNA Homo sapiens
85 DOC2A  
Protein-RNA Homo sapiens
86 RPL31 6160
Protein-RNA Homo sapiens
87 LHX3  
Proximity Label-MS Homo sapiens
88 SNRPB2 6629
Protein-RNA Homo sapiens
89 UBP1 7342
Affinity Capture-MS Homo sapiens
90 PAX8  
Proximity Label-MS Homo sapiens
91 SNRPN 6638
Protein-RNA Homo sapiens
92 RPL37A 6168
Protein-RNA Homo sapiens
93 SNRPD1 6632
Protein-RNA Homo sapiens
94 MYH10 4628
Affinity Capture-MS Homo sapiens
95 AKR1A1 10327
Protein-RNA Homo sapiens
96 DDX17 10521
Protein-RNA Homo sapiens
97 T  
Proximity Label-MS Homo sapiens
98 RPS16 6217
Protein-RNA Homo sapiens
99 RPS15A 6210
Protein-RNA Homo sapiens
100 CEBPA  
Proximity Label-MS Homo sapiens
101 VSX1  
Proximity Label-MS Homo sapiens
102 SP100 6672
Affinity Capture-MS Homo sapiens
103 PCBP2 5094
Protein-RNA Homo sapiens
104 SOX7  
Proximity Label-MS Homo sapiens
105 ANLN 54443
Protein-RNA Homo sapiens
106 MYH7B  
Protein-RNA Homo sapiens
107 NLRC4  
Protein-RNA Homo sapiens
108 HNRNPD 3184
Protein-RNA Homo sapiens
109 SLC22A16 85413
Protein-RNA Homo sapiens
110 PAX6  
Proximity Label-MS Homo sapiens
111 ZDHHC16  
Protein-RNA Homo sapiens
112 WDR11 55717
Protein-RNA Homo sapiens
113 THUMPD1 55623
Protein-RNA Homo sapiens
114 SNRPD2 6633
Protein-RNA Homo sapiens
115 SOX6  
Proximity Label-MS Homo sapiens
116 ELK3  
Proximity Label-MS Homo sapiens
117 RPL35 11224
Protein-RNA Homo sapiens
118 CTNNB1 1499
Affinity Capture-MS Homo sapiens
119 SRSF1 6426
Protein-RNA Homo sapiens
120 HIST1H1E 3008
Protein-RNA Homo sapiens
121 FOXI1  
Proximity Label-MS Homo sapiens
122 PHIP 55023
Affinity Capture-MS Homo sapiens
123 ALDOA 226
Co-localization Homo sapiens
124 FOXL1  
Proximity Label-MS Homo sapiens
125 TTF2 8458
Affinity Capture-MS Homo sapiens
126 HNRNPUL1 11100
Protein-RNA Homo sapiens
127 PKD1P6  
Protein-RNA Homo sapiens
128 SOX15  
Proximity Label-MS Homo sapiens
129 RPL28 6158
Protein-RNA Homo sapiens
130 HNF4A  
Proximity Label-MS Homo sapiens
131 SRSF8 10929
Protein-RNA Homo sapiens
132 MTUS1  
Protein-RNA Homo sapiens
133 UMPS 7372
Protein-RNA Homo sapiens
134 MYC  
Affinity Capture-MS Homo sapiens
135 RPA3 6119
Affinity Capture-MS Homo sapiens
136 MTOR 2475
Affinity Capture-MS Homo sapiens
137 TRA2A 29896
Protein-RNA Homo sapiens
138 RPL22 6146
Protein-RNA Homo sapiens
139 PKD2 5311
Co-localization Homo sapiens
140 RPL23A 6147
Protein-RNA Homo sapiens
141 SMARCA2 6595
Protein-RNA Homo sapiens
142 ZC3HAV1 56829
Protein-RNA Homo sapiens
143 CSDE1 7812
Protein-RNA Homo sapiens
144 HYDIN 54768
Protein-RNA Homo sapiens
145 FOXP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
146 FHL2 2274
Affinity Capture-MS Homo sapiens
147 RBMS2 5939
Protein-RNA Homo sapiens
148 C10orf2 56652
Affinity Capture-MS Homo sapiens
149 IQSEC2 23096
Protein-RNA Homo sapiens
150 SATB1 6304
Affinity Capture-MS Homo sapiens
151 HK2 3099
Co-localization Homo sapiens
152 HERC1 8925
Protein-RNA Homo sapiens
153 TLX1  
Proximity Label-MS Homo sapiens
154 POP7  
Protein-RNA Homo sapiens
155 RPS27A 6233
Protein-RNA Homo sapiens
156 CCDC167  
Protein-RNA Homo sapiens
157 LIG3 3980
Affinity Capture-MS Homo sapiens
158 CPSF6 11052
Protein-RNA Homo sapiens
159 TP53 7157
Affinity Capture-MS Homo sapiens
160 RPL6 6128
Protein-RNA Homo sapiens
161 MTA1 9112
Affinity Capture-Western Homo sapiens
162 TBP  
Affinity Capture-MS Homo sapiens
163 WBP11  
Protein-RNA Homo sapiens
164 HOXD13  
Affinity Capture-MS Homo sapiens
165 KLF3  
Proximity Label-MS Homo sapiens
166 RBMX 27316
Protein-RNA Homo sapiens
167 PTBP1 5725
Affinity Capture-RNA Homo sapiens
Protein-RNA Homo sapiens
168 HSPB1 3315
Protein-RNA Homo sapiens
169 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
170 QSER1  
Affinity Capture-MS Homo sapiens
171 CHD1L 9557
Affinity Capture-MS Homo sapiens
172 ZBTB10 65986
Affinity Capture-MS Homo sapiens
173 SALL1 6299
Affinity Capture-MS Homo sapiens
174 PAX9  
Proximity Label-MS Homo sapiens
175 IL3RA  
Two-hybrid Homo sapiens
176 HNRNPK 3190
Protein-RNA Homo sapiens
177 UNK  
Affinity Capture-RNA Homo sapiens
178 CCDC73  
Protein-RNA Homo sapiens
179 DCD 117159
Protein-RNA Homo sapiens
180 KLF5  
Proximity Label-MS Homo sapiens
181 PAX7  
Proximity Label-MS Homo sapiens
182 RUVBL1 8607
Protein-RNA Homo sapiens
183 GAPDH 2597
Protein-RNA Homo sapiens
184 ALYREF 10189
Protein-RNA Homo sapiens
185 AURKA 6790
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
186 BRD1 23774
Affinity Capture-MS Homo sapiens
187 C1QBP 708
Protein-RNA Homo sapiens
188 ERG  
Proximity Label-MS Homo sapiens
189 PTGES3 10728
Affinity Capture-MS Homo sapiens
190 HNF1B  
Proximity Label-MS Homo sapiens
191 NFIC 4782
Proximity Label-MS Homo sapiens
192 AR 367
Proximity Label-MS Homo sapiens
193 ANXA2 302
Protein-RNA Homo sapiens
194 CHSY1 22856
Protein-RNA Homo sapiens
195 SNRPA1 6627
Protein-RNA Homo sapiens
196 PURA 5813
Protein-RNA Homo sapiens
197 SP7  
Proximity Label-MS Homo sapiens
198 MYL12B 103910
Affinity Capture-MS Homo sapiens
199 PCSK4  
Protein-RNA Homo sapiens
200 PARN  
Protein-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which FOXP1 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Transcriptional regulation of pluripotent stem cells TAS Reactome





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