Gene description for FOXP1
Gene name forkhead box P1
Gene symbol FOXP1
Other names/aliases 12CC4
HSPC215
MFH
QRF1
hFKH1B
Species Homo sapiens
 Database cross references - FOXP1
ExoCarta ExoCarta_27086
Vesiclepedia VP_27086
Entrez Gene 27086
HGNC 3823
MIM 605515
UniProt Q9H334  
 FOXP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FOXP1
Molecular Function
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IEA
    metal ion binding GO:0046872 IEA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    androgen receptor binding GO:0050681 IDA
Biological Process
    response to lipopolysaccharide GO:0032496 IDA
    osteoclast development GO:0036035 IDA
    regulation of interleukin-1 beta secretion GO:0050706 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    regulation of monocyte differentiation GO:0045655 IDA
    T follicular helper cell differentiation GO:0061470 ISS
    regulation of interleukin-12 secretion GO:2001182 IDA
    positive regulation of smooth muscle cell proliferation GO:0048661 IMP
    regulation of tumor necrosis factor production GO:0032680 IDA
    positive regulation of endothelial cell migration GO:0010595 IMP
    negative regulation of androgen receptor signaling pathway GO:0060766 IDA
    interleukin-21 secretion GO:0072619 ISS
    regulation of defense response to bacterium GO:1900424 IDA
    regulation of inflammatory response GO:0050727 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IBA
    transcription from RNA polymerase II promoter GO:0006366 IBA
    chemokine (C-C motif) ligand 2 secretion GO:0035926 IDA
    macrophage activation GO:0042116 IDA
    regulation of macrophage colony-stimulating factor production GO:1901256 IDA
    osteoclast differentiation GO:0030316 IDA
    regulation of endothelial tube morphogenesis GO:1901509 IMP
    anatomical structure morphogenesis GO:0009653 IBA
    monocyte activation GO:0042117 IDA
    negative regulation of B cell apoptotic process GO:0002903 IDA
    endothelial cell activation GO:0042118 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified FOXP1 in exosomes
1
Experiment ID 235
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FOXP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTBP1 1487
Affinity Capture-Western Homo sapiens
2 FOXP4  
Affinity Capture-Western Homo sapiens
3 FOXP1 27086
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 FOXP2 93986
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which FOXP1 is involved
No pathways found





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