Gene description for C10orf2
Gene name chromosome 10 open reading frame 2
Gene symbol C10orf2
Other names/aliases ATXN8
IOSCA
MTDPS7
PEO
PEO1
PEOA3
PRLTS5
SANDO
SCA8
TWINL
Species Homo sapiens
 Database cross references - C10orf2
ExoCarta ExoCarta_56652
Entrez Gene 56652
HGNC 1160
MIM 606075
UniProt Q96RR1  
 C10orf2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for C10orf2
Molecular Function
    ATP binding GO:0005524 IEA
    single-stranded DNA binding GO:0003697 IDA
    protease binding GO:0002020 IPI
    5'-3' DNA helicase activity GO:0043139 IDA
Biological Process
    organelle organization GO:0006996 TAS
    transcription from mitochondrial promoter GO:0006390 IMP
    DNA unwinding involved in DNA replication GO:0006268 IEA
    mitochondrion organization GO:0007005 TAS
    protein homooligomerization GO:0051260 IDA
    protein hexamerization GO:0034214 IDA
    mitochondrial DNA replication GO:0006264 NAS
Subcellular Localization
    mitochondrial nucleoid GO:0042645 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified C10orf2 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for C10orf2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MGR2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C10orf2 is involved
PathwayEvidenceSource
Transcriptional activation of mitochondrial biogenesis TAS Reactome





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