Gene description for C10orf2
Gene name chromosome 10 open reading frame 2
Gene symbol C10orf2
Other names/aliases ATXN8
IOSCA
MTDPS7
PEO
PEO1
PEOA3
PRLTS5
SANDO
SCA8
TWINL
Species Homo sapiens
 Database cross references - C10orf2
ExoCarta ExoCarta_56652
Vesiclepedia VP_56652
Entrez Gene 56652
HGNC 1160
MIM 606075
UniProt Q96RR1  
 C10orf2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for C10orf2
Molecular Function
    protease binding GO:0002020 IPI
    DNA helicase activity GO:0003678 IBA
    DNA clamp loader activity GO:0003689 IEA
    single-stranded DNA binding GO:0003697 IBA
    single-stranded DNA binding GO:0003697 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    lipid binding GO:0008289 IDA
    four-way junction helicase activity GO:0009378 IEA
    isomerase activity GO:0016853 IEA
    ATP hydrolysis activity GO:0016887 IDA
    double-stranded DNA helicase activity GO:0036121 IEA
    identical protein binding GO:0042802 IPI
    5'-3' DNA helicase activity GO:0043139 IDA
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
Biological Process
    mitochondrial DNA replication GO:0006264 IBA
    mitochondrial DNA replication GO:0006264 IMP
    mitochondrial DNA replication GO:0006264 NAS
    DNA unwinding involved in DNA replication GO:0006268 IDA
    chromatin remodeling GO:0006338 IEA
    mitochondrial transcription GO:0006390 IMP
    protein hexamerization GO:0034214 IDA
    cellular response to glucose stimulus GO:0071333 IEA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    mitochondrial chromosome GO:0000262 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial matrix GO:0005759 TAS
    mitochondrial nucleoid GO:0042645 IDA
 Experiment description of studies that identified C10orf2 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for C10orf2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPC 3183
Affinity Capture-MS Homo sapiens
2 SPECC1L 23384
Affinity Capture-MS Homo sapiens
3 ARPC5L 81873
Affinity Capture-MS Homo sapiens
4 CPOX 1371
Co-fractionation Homo sapiens
5 SRPK2 6733
Affinity Capture-MS Homo sapiens
6 BTF3 689
Affinity Capture-MS Homo sapiens
7 TRUB2  
Proximity Label-MS Homo sapiens
8 EN1  
Affinity Capture-MS Homo sapiens
9 MTG2  
Proximity Label-MS Homo sapiens
10 NGRN  
Proximity Label-MS Homo sapiens
11 XPA  
Affinity Capture-MS Homo sapiens
12 CHCHD1  
Proximity Label-MS Homo sapiens
13 RPUSD4 84881
Proximity Label-MS Homo sapiens
14 ZBTB1  
Affinity Capture-MS Homo sapiens
15 MTRF1  
Proximity Label-MS Homo sapiens
16 GFM2 84340
Proximity Label-MS Homo sapiens
17 LRPPRC 10128
Proximity Label-MS Homo sapiens
18 TFAM 7019
Proximity Label-MS Homo sapiens
19 PMPCA 23203
Proximity Label-MS Homo sapiens
20 ZNF524  
Affinity Capture-MS Homo sapiens
21 B4GALT7 11285
Affinity Capture-MS Homo sapiens
22 PRC1 9055
Affinity Capture-MS Homo sapiens
23 HINT2 84681
Proximity Label-MS Homo sapiens
24 NCOA5  
Affinity Capture-MS Homo sapiens
25 PHLDB2 90102
Affinity Capture-MS Homo sapiens
26 MRPS26 64949
Proximity Label-MS Homo sapiens
27 EXD2  
Proximity Label-MS Homo sapiens
28 YWHAH 7533
Affinity Capture-MS Homo sapiens
29 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 AKTIP  
Two-hybrid Homo sapiens
31 TACO1  
Proximity Label-MS Homo sapiens
32 VWA8 23078
Proximity Label-MS Homo sapiens
33 FAM120A 23196
Affinity Capture-MS Homo sapiens
34 MTERF3  
Proximity Label-MS Homo sapiens
35 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
36 FOXP1 27086
Affinity Capture-MS Homo sapiens
37 MDH2 4191
Proximity Label-MS Homo sapiens
38 RBMX 27316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KLF16  
Affinity Capture-MS Homo sapiens
40 HEXIM1 10614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 C6orf203  
Proximity Label-MS Homo sapiens
42 SHISA3  
Affinity Capture-MS Homo sapiens
43 C1QTNF8  
Affinity Capture-MS Homo sapiens
44 RB1CC1 9821
Affinity Capture-MS Homo sapiens
45 RPL4 6124
Affinity Capture-MS Homo sapiens
46 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 GOLGA8A 23015
Affinity Capture-MS Homo sapiens
48 SRSF6 6431
Affinity Capture-MS Homo sapiens
49 RAD9A  
Affinity Capture-MS Homo sapiens
50 HSCB 150274
Proximity Label-MS Homo sapiens
51 SP1  
Affinity Capture-MS Homo sapiens
52 ACTL8  
Affinity Capture-MS Homo sapiens
53 PNMA2  
Affinity Capture-MS Homo sapiens
54 TBRG4 9238
Proximity Label-MS Homo sapiens
55 CBX6  
Affinity Capture-MS Homo sapiens
56 MTFMT  
Proximity Label-MS Homo sapiens
57 MRPL11 65003
Proximity Label-MS Homo sapiens
58 MTRF1L  
Proximity Label-MS Homo sapiens
59 EPB41L5 57669
Affinity Capture-MS Homo sapiens
60 CDX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CHD9 80205
Affinity Capture-MS Homo sapiens
62 MAP7 9053
Affinity Capture-MS Homo sapiens
63 MRRF  
Proximity Label-MS Homo sapiens
64 MAP4 4134
Affinity Capture-MS Homo sapiens
65 MRPS12  
Proximity Label-MS Homo sapiens
66 MTIF2 4528
Proximity Label-MS Homo sapiens
67 TLX1  
Affinity Capture-MS Homo sapiens
68 MTIF3  
Proximity Label-MS Homo sapiens
69 TUFM 7284
Proximity Label-MS Homo sapiens
70 CKAP2  
Affinity Capture-MS Homo sapiens
71 PDIA3 2923
Cross-Linking-MS (XL-MS) Homo sapiens
72 EGFR 1956
Negative Genetic Homo sapiens
73 LYSMD2  
Affinity Capture-MS Homo sapiens
74 DCAF8 50717
Affinity Capture-MS Homo sapiens
75 C12orf65  
Proximity Label-MS Homo sapiens
76 PMPCB 9512
Proximity Label-MS Homo sapiens
77 TPM1 7168
Affinity Capture-MS Homo sapiens
78 CLEC11A 6320
Affinity Capture-MS Homo sapiens
79 SMAD9  
Two-hybrid Homo sapiens
80 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PABPC5 140886
Affinity Capture-MS Homo sapiens
82 TRIM27  
Affinity Capture-MS Homo sapiens
83 ACAD9 28976
Proximity Label-MS Homo sapiens
84 BMI1  
Affinity Capture-MS Homo sapiens
85 METTL15  
Proximity Label-MS Homo sapiens
86 PYHIN1  
Affinity Capture-MS Homo sapiens
87 ZNF263  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 KCTD13 253980
Affinity Capture-MS Homo sapiens
90 HECTD1 25831
Affinity Capture-MS Homo sapiens
91 RPL13 6137
Affinity Capture-MS Homo sapiens
92 CLPP 8192
Proximity Label-MS Homo sapiens
93 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
94 TSFM 10102
Proximity Label-MS Homo sapiens
95 AUH 549
Proximity Label-MS Homo sapiens
96 DNAJC19 131118
Proximity Label-MS Homo sapiens
97 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
98 PRIMPOL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ZNF169 169841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PDHA1 5160
Proximity Label-MS Homo sapiens
102 SQSTM1 8878
Affinity Capture-MS Homo sapiens
103 COX8A  
Proximity Label-MS Homo sapiens
104 C21orf33  
Proximity Label-MS Homo sapiens
105 SSBP1 6742
Proximity Label-MS Homo sapiens
106 GFM1 85476
Proximity Label-MS Homo sapiens
107 AARS2  
Proximity Label-MS Homo sapiens
108 TEFM  
Proximity Label-MS Homo sapiens
109 SRSF7 6432
Affinity Capture-MS Homo sapiens
110 CLTA 1211
Affinity Capture-MS Homo sapiens
111 C1QBP 708
Proximity Label-MS Homo sapiens
112 KRAS 3845
Negative Genetic Homo sapiens
113 MZF1  
Affinity Capture-MS Homo sapiens
114 METTL17  
Proximity Label-MS Homo sapiens
115 ZNF467  
Affinity Capture-MS Homo sapiens
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