Gene description for HEXIM1
Gene name hexamethylene bis-acetamide inducible 1
Gene symbol HEXIM1
Other names/aliases CLP1
EDG1
HIS1
MAQ1
Species Homo sapiens
 Database cross references - HEXIM1
ExoCarta ExoCarta_10614
Entrez Gene 10614
HGNC 24953
MIM 607328
UniProt O94992  
 HEXIM1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for HEXIM1
Molecular Function
    cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IDA
    protein binding GO:0005515 IPI
    snRNA binding GO:0017069 IDA
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    positive regulation of signal transduction by p53 class mediator GO:1901798 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    heart development GO:0007507 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified HEXIM1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HEXIM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNT2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 RELA  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
3 CCNT1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 RN7SK 125050
Affinity Capture-Western Homo sapiens
5 CDK9 1025
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which HEXIM1 is involved
No pathways found





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