Gene description for SREBF2
Gene name	sterol regulatory element binding transcription factor 2
Gene symbol	SREBF2
Other names/aliases	SREBP-2 SREBP2 bHLHd2
Species	Homo sapiens
Database cross references - SREBF2
ExoCarta	ExoCarta_6721
Vesiclepedia	VP_6721
Entrez Gene	6721
HGNC	11290
MIM	600481
UniProt	Q12772
SREBF2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for SREBF2

Molecular Function     E-box binding GO:0070888 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA     protein dimerization activity GO:0046983 IEA     protein binding GO:0005515 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     C-8 sterol isomerase activity GO:0000247 IDA     protein C-terminus binding GO:0008022 IPI Biological Process     negative regulation of cholesterol efflux GO:0090370 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     lipid metabolic process GO:0006629 TAS     positive regulation of cholesterol storage GO:0010886 IDA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     positive regulation of protein targeting to mitochondrion GO:1903955 IMP     transcription, DNA-templated GO:0006351 IEA     cellular response to laminar fluid shear stress GO:0071499 NAS     cellular response to starvation GO:0009267 IMP     regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter GO:0072368 IDA     regulation of mitochondrion degradation GO:1903146 IMP     small molecule metabolic process GO:0044281 TAS     response to low-density lipoprotein particle GO:0055098 IEP     regulation of cholesterol homeostasis GO:2000188 IEA     cholesterol metabolic process GO:0008203 IEA Subcellular Localization     nucleolus GO:0005730 IDA     nucleus GO:0005634 IDA     endoplasmic reticulum membrane GO:0005789 TAS     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     endoplasmic reticulum GO:0005783 IDA     SREBP-SCAP-Insig complex GO:0032937 IDA     ER to Golgi transport vesicle membrane GO:0012507 IEA     Golgi membrane GO:0000139 TAS     nucleoplasm GO:0005654 TAS