Gene description for ATF7IP
Gene name activating transcription factor 7 interacting protein
Gene symbol ATF7IP
Other names/aliases AM
ATF-IP
MCAF
MCAF1
p621
Species Homo sapiens
 Database cross references - ATF7IP
ExoCarta ExoCarta_55729
Entrez Gene 55729
HGNC 20092
MIM 613644
UniProt Q6VMQ6  
 ATF7IP identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ATF7IP
Molecular Function
    protein binding GO:0005515 IPI
    ATPase activity GO:0016887 IEA
    transcription corepressor activity GO:0003714 IEA
Biological Process
    DNA methylation GO:0006306 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045898 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    viral process GO:0016032 IEA
    chromatin organization GO:0006325 TAS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    transcription factor complex GO:0005667 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ATF7IP in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ATF7IP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MBD1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 DISC1 27185
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ATF7IP is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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