Gene description for ATF7IP2
Gene name activating transcription factor 7 interacting protein 2
Gene symbol ATF7IP2
Other names/aliases MCAF2
Species Homo sapiens
 Database cross references - ATF7IP2
ExoCarta ExoCarta_80063
Vesiclepedia VP_80063
Entrez Gene 80063
HGNC 20397
MIM 613645
UniProt Q5U623  
 ATF7IP2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ATF7IP2
Molecular Function
    transcription coregulator activity GO:0003712 IBA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    transcription regulator complex GO:0005667 IBA
 Experiment description of studies that identified ATF7IP2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ATF7IP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRA6 64220
Affinity Capture-MS Homo sapiens
2 SP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 NUP62 23636
Two-hybrid Homo sapiens
4 FSD2 123722
Two-hybrid Homo sapiens
5 MBD1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
6 ATF7IP 55729
Affinity Capture-MS Homo sapiens
7 ARL14EP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 EGFR 1956
Affinity Capture-MS Homo sapiens
9 MED4 29079
Two-hybrid Homo sapiens
10 SPSB2  
Affinity Capture-MS Homo sapiens
11 DDX58 23586
Affinity Capture-RNA Homo sapiens
12 SETDB1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATF7IP2 is involved
No pathways found





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