Gene description for STRA6
Gene name stimulated by retinoic acid 6
Gene symbol STRA6
Other names/aliases MCOPCB8
MCOPS9
PP14296
Species Homo sapiens
 Database cross references - STRA6
ExoCarta ExoCarta_64220
Vesiclepedia VP_64220
Entrez Gene 64220
HGNC 30650
MIM 610745
UniProt Q9BX79  
 STRA6 identified in sEVs derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
 Gene ontology annotations for STRA6
Molecular Function
    protein binding GO:0005515 IPI
    retinal binding GO:0016918 IEA
    retinol binding GO:0019841 IEA
    retinol transmembrane transporter activity GO:0034632 IDA
    signaling receptor activity GO:0038023 IEA
Biological Process
    blood vessel development GO:0001568 IMP
    kidney development GO:0001822 IMP
    pulmonary valve morphogenesis GO:0003184 IMP
    ventricular septum development GO:0003281 IMP
    heart development GO:0007507 IMP
    learning GO:0007612 IMP
    feeding behavior GO:0007631 IMP
    lung development GO:0030324 IMP
    adrenal gland development GO:0030325 IMP
    female genitalia development GO:0030540 IMP
    retinol transport GO:0034633 IDA
    vocal learning GO:0042297 IMP
    camera-type eye development GO:0043010 IMP
    ear development GO:0043583 IMP
    nose morphogenesis GO:0043585 IMP
    lung alveolus development GO:0048286 IMP
    positive regulation of behavior GO:0048520 IMP
    digestive tract morphogenesis GO:0048546 IMP
    embryonic digestive tract development GO:0048566 IMP
    developmental growth GO:0048589 IMP
    smooth muscle tissue development GO:0048745 IMP
    artery morphogenesis GO:0048844 IMP
    cognition GO:0050890 IMP
    neuromuscular process GO:0050905 IMP
    head development GO:0060322 IMP
    head morphogenesis GO:0060323 IMP
    face morphogenesis GO:0060325 IMP
    lung vasculature development GO:0060426 IMP
    diaphragm development GO:0060539 IMP
    embryonic camera-type eye formation GO:0060900 IMP
    eyelid development in camera-type eye GO:0061029 IMP
    uterus morphogenesis GO:0061038 IMP
    alveolar primary septum development GO:0061143 IMP
    pulmonary artery morphogenesis GO:0061156 IMP
    paramesonephric duct development GO:0061205 IMP
    vitamin A import into cell GO:0071939 IBA
    ductus arteriosus closure GO:0097070 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified STRA6 in sEVs
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STRA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCAM 4162
Proximity Label-MS Homo sapiens
2 GLRX3 10539
Two-hybrid Homo sapiens
3 MTMR1 8776
Affinity Capture-MS Homo sapiens
4 RER1 11079
Affinity Capture-MS Homo sapiens
5 PTPN2 5771
Affinity Capture-MS Homo sapiens
6 FASN 2194
Negative Genetic Homo sapiens
7 KRTAP10-6  
Two-hybrid Homo sapiens
8 GPR89A  
Affinity Capture-MS Homo sapiens
9 ATF7IP2 80063
Affinity Capture-MS Homo sapiens
10 PTPN1 5770
Affinity Capture-MS Homo sapiens
11 NTRK1 4914
Affinity Capture-MS Homo sapiens
12 KRTAP6-3  
Two-hybrid Homo sapiens
13 SLC9A1 6548
Affinity Capture-MS Homo sapiens
14 NUP35 129401
Proximity Label-MS Homo sapiens
15 STXBP3 6814
Affinity Capture-MS Homo sapiens
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