Gene description for MTMR1
Gene name myotubularin related protein 1
Gene symbol MTMR1
Other names/aliases -
Species Homo sapiens
 Database cross references - MTMR1
ExoCarta ExoCarta_8776
Vesiclepedia VP_8776
Entrez Gene 8776
HGNC 7449
MIM 300171
UniProt Q13613  
 MTMR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MTMR1
Molecular Function
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IBA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IDA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 ISS
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 TAS
    protein homodimerization activity GO:0042803 IPI
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 IBA
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 IDA
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 TAS
Biological Process
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    phosphatidylinositol dephosphorylation GO:0046856 IBA
    phosphatidylinositol dephosphorylation GO:0046856 IDA
    regulation of phosphatidylinositol dephosphorylation GO:0060304 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IBA
 Experiment description of studies that identified MTMR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTMR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRA6 64220
Affinity Capture-MS Homo sapiens
2 CD6 923
Affinity Capture-MS Homo sapiens
3 TMEM52B 120939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MECP2 4204
Affinity Capture-MS Homo sapiens
5 SCHIP1  
Affinity Capture-MS Homo sapiens
6 RAB6B 51560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC4A1AP  
Affinity Capture-MS Homo sapiens
8 FBXW11  
Affinity Capture-MS Homo sapiens
9 GMNN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NSUN5P1  
Affinity Capture-MS Homo sapiens
11 FEM1A  
Affinity Capture-MS Homo sapiens
12 FTL 2512
Affinity Capture-MS Homo sapiens
13 NDUFB10 4716
Affinity Capture-MS Homo sapiens
14 MARCKS 4082
Proximity Label-MS Homo sapiens
15 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
16 HCST  
Affinity Capture-MS Homo sapiens
17 USP9X 8239
Affinity Capture-MS Homo sapiens
18 TRIM10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 VPRBP 9730
Affinity Capture-MS Homo sapiens
20 LAMP1 3916
Proximity Label-MS Homo sapiens
21 RAB35 11021
Proximity Label-MS Homo sapiens
22 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 S100A2 6273
Affinity Capture-MS Homo sapiens
24 SULT1C4  
Affinity Capture-MS Homo sapiens
25 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
26 PI15  
Affinity Capture-MS Homo sapiens
27 NAA11 84779
Affinity Capture-MS Homo sapiens
28 EFNB1 1947
Affinity Capture-MS Homo sapiens
29 IGFBP3 3486
Affinity Capture-MS Homo sapiens
30 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
31 LRRC4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SBF2 81846
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NADK 65220
Affinity Capture-MS Homo sapiens
34 EFNB3 1949
Affinity Capture-MS Homo sapiens
35 ERBB3 2065
Two-hybrid Homo sapiens
36 SBF1 6305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 RPGR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 BEX4  
Affinity Capture-MS Homo sapiens
39 BPNT1 10380
Affinity Capture-MS Homo sapiens
40 MTMR9 66036
Affinity Capture-MS Homo sapiens
41 LYN 4067
Proximity Label-MS Homo sapiens
42 ROR2 4920
Two-hybrid Homo sapiens
43 DNAJC5 80331
Proximity Label-MS Homo sapiens
44 AURKB 9212
Affinity Capture-MS Homo sapiens
45 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CEP250 11190
Affinity Capture-MS Homo sapiens
47 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 C12orf74  
Affinity Capture-MS Homo sapiens
49 FOS 2353
Affinity Capture-MS Homo sapiens
50 LIPC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 C16orf72 29035
Affinity Capture-MS Homo sapiens
52 DUSP16  
Affinity Capture-MS Homo sapiens
53 WDR5 11091
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
54 CXADR 1525
Proximity Label-MS Homo sapiens
55 PNMA2  
Affinity Capture-MS Homo sapiens
56 PPP4R1L  
Affinity Capture-MS Homo sapiens
57 EPHA2 1969
Proximity Label-MS Homo sapiens
58 ACTB 60
Proximity Label-MS Homo sapiens
59 KRAS 3845
Proximity Label-MS Homo sapiens
60 RHOB 388
Proximity Label-MS Homo sapiens
61 MTMR2 8898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SLC31A1 1317
Affinity Capture-MS Homo sapiens
63 IGFL3  
Affinity Capture-MS Homo sapiens
64 TRIM17  
Affinity Capture-MS Homo sapiens
65 PSMC2 5701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CAV1 857
Proximity Label-MS Homo sapiens
68 CRYL1 51084
Affinity Capture-MS Homo sapiens
69 SELE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HUWE1 10075
Affinity Capture-MS Homo sapiens
71 PIPSL 266971
Affinity Capture-MS Homo sapiens
72 PTK7 5754
Two-hybrid Homo sapiens
View the network image/svg+xml



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