Gene description for NADK
Gene name NAD kinase
Gene symbol NADK
Other names/aliases dJ283E3.1
Species Homo sapiens
 Database cross references - NADK
ExoCarta ExoCarta_65220
Entrez Gene 65220
HGNC 29831
MIM 611616
UniProt O95544  
 NADK identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NADK
Molecular Function
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    NAD+ kinase activity GO:0003951 TAS
    protein binding GO:0005515 IPI
Biological Process
    NAD metabolic process GO:0019674 TAS
    NADP biosynthetic process GO:0006741 IEA
    vitamin metabolic process GO:0006766 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    phosphorylation GO:0016310 NAS
    small molecule metabolic process GO:0044281 TAS
    ATP metabolic process GO:0046034 NAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified NADK in exosomes
Experiment ID 236
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NADK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LNX  
Two-hybrid Homo sapiens
2 FLJ22494  
Two-hybrid Homo sapiens
3 GLRX3 10539
Two-hybrid Homo sapiens
4 EEF1G 1937
Two-hybrid Homo sapiens
5 YWHAZ 7534
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NADK is involved
Nicotinate metabolism TAS Reactome

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