Gene description for DCLK1
Gene name doublecortin-like kinase 1
Gene symbol DCLK1
Other names/aliases CL1
CLICK1
DCAMKL1
DCDC3A
DCLK
Species Homo sapiens
 Database cross references - DCLK1
ExoCarta ExoCarta_9201
Entrez Gene 9201
HGNC 2700
MIM 604742
UniProt O15075  
 DCLK1 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for DCLK1
Molecular Function
    receptor signaling protein activity GO:0005057 TAS
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    protein kinase activity GO:0004672 TAS
Biological Process
    neuron migration GO:0001764 IEA
    protein phosphorylation GO:0006468 IEA
    response to virus GO:0009615 IEP
    intracellular signal transduction GO:0035556 IEA
    dendrite morphogenesis GO:0048813 IEA
    central nervous system projection neuron axonogenesis GO:0021952 IEA
    endosomal transport GO:0016197 NAS
    nervous system development GO:0007399 TAS
    forebrain development GO:0030900 IEA
    axon extension GO:0048675 IEA
    central nervous system development GO:0007417 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    intracellular GO:0005622 NAS
 Experiment description of studies that identified DCLK1 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DCLK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DCLK1 is involved
No pathways found





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