Gene description for STARD13
Gene name StAR-related lipid transfer (START) domain containing 13
Gene symbol STARD13
Other names/aliases ARHGAP37
DLC2
GT650
LINC00464
Species Homo sapiens
 Database cross references - STARD13
ExoCarta ExoCarta_90627
Vesiclepedia VP_90627
Entrez Gene 90627
HGNC 19164
MIM 609866
UniProt Q9Y3M8  
 STARD13 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for STARD13
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    signal transduction GO:0007165 IEA
    actin cytoskeleton organization GO:0030036 IBA
    regulation of Rho protein signal transduction GO:0035023 IBA
    endothelial cell migration GO:0043542 IGI
    endothelial cell migration GO:0043542 IMP
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IGI
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IMP
    endothelial tube lumen extension GO:0097498 IGI
    endothelial tube lumen extension GO:0097498 IMP
Subcellular Localization
    lipid droplet GO:0005811 IEA
    cytosol GO:0005829 TAS
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified STARD13 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for STARD13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DENND4C 55667
Affinity Capture-MS Homo sapiens
2 LRFN1  
Affinity Capture-MS Homo sapiens
3 LIMA1 51474
Affinity Capture-MS Homo sapiens
4 HMGCR  
Two-hybrid Homo sapiens
5 KIF1B 23095
Two-hybrid Homo sapiens
6 EPB41L1 2036
Two-hybrid Homo sapiens
7 SERPINB4 6318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 DCLK1 9201
Affinity Capture-MS Homo sapiens
9 KSR1  
Affinity Capture-MS Homo sapiens
10 TAX1BP1 8887
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
11 RTKN 6242
Affinity Capture-MS Homo sapiens
12 DENND1A 57706
Affinity Capture-MS Homo sapiens
13 PPM1H  
Affinity Capture-MS Homo sapiens
14 INPP5E 56623
Affinity Capture-MS Homo sapiens
15 ZNF638 27332
Affinity Capture-MS Homo sapiens
16 S100A7 6278
Affinity Capture-MS Homo sapiens
17 SRGAP2 23380
Affinity Capture-MS Homo sapiens
18 MAGI1  
Affinity Capture-MS Homo sapiens
19 BAI2  
Two-hybrid Homo sapiens
20 CBY1  
Affinity Capture-MS Homo sapiens
21 HSP90AA1 3320
Two-hybrid Homo sapiens
22 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
23 EIF4E2  
Affinity Capture-MS Homo sapiens
24 TESK2  
Affinity Capture-MS Homo sapiens
25 TUBA1A 7846
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
26 SMAD1 4086
Two-hybrid Homo sapiens
27 NF1 4763
Affinity Capture-MS Homo sapiens
28 CDC25C  
Affinity Capture-MS Homo sapiens
29 KIF13B 23303
Affinity Capture-MS Homo sapiens
30 TBCB 1155
Cross-Linking-MS (XL-MS) Homo sapiens
31 ZBTB21  
Affinity Capture-MS Homo sapiens
32 GIGYF1  
Affinity Capture-MS Homo sapiens
33 RPS6 6194
Cross-Linking-MS (XL-MS) Homo sapiens
34 ITPR1 3708
Two-hybrid Homo sapiens
35 CGN  
Affinity Capture-MS Homo sapiens
36 SMARCD3  
Two-hybrid Homo sapiens
37 MAST3  
Affinity Capture-MS Homo sapiens
38 HDAC4  
Affinity Capture-MS Homo sapiens
39 KCTD3  
Affinity Capture-MS Homo sapiens
40 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
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