Gene description for SIPA1L1
Gene name signal-induced proliferation-associated 1 like 1
Gene symbol SIPA1L1
Other names/aliases E6TP1
Species Homo sapiens
 Database cross references - SIPA1L1
ExoCarta ExoCarta_26037
Entrez Gene 26037
HGNC 20284
UniProt O43166  
 SIPA1L1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SIPA1L1
Molecular Function
    molecular_function GO:0003674 ND
    GTPase activator activity GO:0005096 IEA
    ephrin receptor binding GO:0046875 IEA
Biological Process
    regulation of synaptic plasticity GO:0048167 ISS
    regulation of axonogenesis GO:0050770 ISS
    regulation of GTPase activity GO:0043087 ISS
    activation of GTPase activity GO:0090630 ISS
    biological_process GO:0008150 ND
    ephrin receptor signaling pathway GO:0048013 ISS
    regulation of dendritic spine morphogenesis GO:0061001 ISS
    actin cytoskeleton reorganization GO:0031532 ISS
Subcellular Localization
    cell junction GO:0030054 IEA
    postsynaptic density GO:0014069 ISS
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    postsynaptic membrane GO:0045211 IEA
    dendritic spine GO:0043197 ISS
 Experiment description of studies that identified SIPA1L1 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SIPA1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLG4  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SIPA1L1 is involved
No pathways found





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