Gene description for Myo1c
Gene name myosin IC
Gene symbol Myo1c
Other names/aliases C80397
MMIb
MYO1E
NMI
mm1beta
myr2
Species Mus musculus
 Database cross references - Myo1c
ExoCarta ExoCarta_17913
Entrez Gene 17913
UniProt Q9WTI7  
 Myo1c identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Myo1c
Molecular Function
    receptor binding GO:0005102 ISO
    protein C-terminus binding GO:0008022 IPI
    Ral GTPase binding GO:0017160 ISO
    motor activity GO:0003774 IEA
    actin binding GO:0003779 NAS
    calmodulin binding GO:0005516 NAS
    phospholipid binding GO:0005543 TAS
    protein binding GO:0005515 IPI
    actin-dependent ATPase activity GO:0030898 ISO
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 NAS
Biological Process
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 ISO
    transport GO:0006810 IDA
    protein transport GO:0015031 IEA
    positive regulation of protein targeting to membrane GO:0090314 ISO
    positive regulation of cell migration by vascular endothelial growth factor signaling pathway GO:0038089 ISO
    positive regulation of cell migration GO:0030335 ISO
    mRNA transport GO:0051028 IEA
    protein targeting GO:0006605 ISO
    metabolic process GO:0008152 ISO
    protein targeting to membrane GO:0006612 ISO
    regulation of bicellular tight junction assembly GO:2000810 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    nuclear pore GO:0005643 IEA
    brush border GO:0005903 IDA
    stereocilium GO:0032420 IDA
    cytoplasmic vesicle GO:0031410 IEA
    basal plasma membrane GO:0009925 ISO
    nucleus GO:0005634 ISO
    membrane GO:0016020 TAS
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    cell projection GO:0042995 IEA
    myosin complex GO:0016459 IEA
    microvillus GO:0005902 ISO
    nucleoplasm GO:0005654 ISO
    membrane raft GO:0045121 ISO
    myosin I complex GO:0045160 IDA
    lateral plasma membrane GO:0016328 ISO
    filamentous actin GO:0031941 ISO
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Myo1c in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Myo1c
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here