Gene description for Myo1c
Gene name myosin IC
Gene symbol Myo1c
Other names/aliases C80397
MMIb
MYO1E
NMI
mm1beta
myr2
Species Mus musculus
 Database cross references - Myo1c
ExoCarta ExoCarta_17913
Vesiclepedia VP_17913
Entrez Gene 17913
UniProt Q9WTI7  
 Myo1c identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Myo1c
Molecular Function
    microfilament motor activity GO:0000146 EXP
    microfilament motor activity GO:0000146 IBA
    microfilament motor activity GO:0000146 ISO
    actin binding GO:0003779 NAS
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 ISO
    calmodulin binding GO:0005516 NAS
    ATP binding GO:0005524 NAS
    phospholipid binding GO:0005543 TAS
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 ISO
Biological Process
    chromatin remodeling GO:0006338 NAS
    protein targeting to membrane GO:0006612 IEA
    protein targeting to membrane GO:0006612 ISO
    endocytosis GO:0006897 IBA
    actin filament organization GO:0007015 IBA
    actin filament-based movement GO:0030048 IBA
    vesicle transport along actin filament GO:0030050 IDA
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of actin filament polymerization GO:0030838 ISO
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 ISO
    positive regulation of transcription by RNA polymerase I GO:0045943 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    positive regulation of transcription by RNA polymerase III GO:0045945 ISO
    cellular response to type II interferon GO:0071346 IDA
    positive regulation of protein targeting to membrane GO:0090314 IDA
    positive regulation of protein targeting to membrane GO:0090314 IMP
    positive regulation of cellular response to insulin stimulus GO:1900078 IDA
    positive regulation of cellular response to insulin stimulus GO:1900078 IMP
    positive regulation of cellular response to insulin stimulus GO:1900078 ISO
    regulation of bicellular tight junction assembly GO:2000810 IEA
    regulation of bicellular tight junction assembly GO:2000810 ISO
Subcellular Localization
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 NAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    microvillus GO:0005902 IBA
    microvillus GO:0005902 IEA
    microvillus GO:0005902 ISO
    brush border GO:0005903 IDA
    cell cortex GO:0005938 IEA
    basal plasma membrane GO:0009925 IEA
    basal plasma membrane GO:0009925 ISO
    actin cytoskeleton GO:0015629 IBA
    membrane GO:0016020 ISO
    membrane GO:0016020 TAS
    lateral plasma membrane GO:0016328 IEA
    lateral plasma membrane GO:0016328 ISO
    myosin complex GO:0016459 IEA
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    cytoplasmic vesicle membrane GO:0030659 IDA
    filamentous actin GO:0031941 IEA
    filamentous actin GO:0031941 ISO
    stereocilium GO:0032420 IDA
    stereocilium bundle GO:0032421 ISO
    ruffle membrane GO:0032587 IEA
    ruffle membrane GO:0032587 ISO
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
    phagocytic vesicle GO:0045335 IDA
    stereocilium membrane GO:0060171 IEA
    B-WICH complex GO:0110016 ISO
 Experiment description of studies that identified Myo1c in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Myo1c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTR2 10097
Affinity Capture-MS Homo sapiens
2 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
3 ABLIM1 3983
Affinity Capture-MS Homo sapiens
4 MYL6B 140465
Affinity Capture-MS Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 AAK1 22848
Affinity Capture-MS Homo sapiens
7 ARPC2 10109
Affinity Capture-MS Homo sapiens
8 TPM2 7169
Affinity Capture-MS Homo sapiens
9 ARPC4 10093
Affinity Capture-MS Homo sapiens
10 CARD10  
Affinity Capture-MS Homo sapiens
11 JPH1 56704
Affinity Capture-MS Homo sapiens
12 DBN1 1627
Affinity Capture-MS Homo sapiens
13 STON2 85439
Affinity Capture-MS Homo sapiens
14 EPS15 2060
Affinity Capture-MS Homo sapiens
15 GAS2L3  
Affinity Capture-MS Homo sapiens
16 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
17 CALM1 801
Affinity Capture-MS Homo sapiens
18 CFL1 1072
Affinity Capture-MS Homo sapiens
19 CLTB 1212
Affinity Capture-MS Homo sapiens
20 VASP 7408
Affinity Capture-MS Homo sapiens
21 PPP1CC 5501
Affinity Capture-MS Homo sapiens
22 CAPZB 832
Affinity Capture-MS Homo sapiens
23 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
24 CORO1B 57175
Affinity Capture-MS Homo sapiens
25 ZDHHC5 25921
Affinity Capture-MS Homo sapiens
26 Iqcb1  
Affinity Capture-MS Mus musculus
27 MYO5B 4645
Affinity Capture-MS Homo sapiens
28 ACTR3 10096
Affinity Capture-MS Homo sapiens
29 AP2A1 160
Affinity Capture-MS Homo sapiens
30 CD109 135228
Affinity Capture-MS Homo sapiens
31 SPECC1L 23384
Affinity Capture-MS Homo sapiens
32 ADD1 118
Affinity Capture-MS Homo sapiens
33 TOM1 10043
Affinity Capture-MS Homo sapiens
34 MYO1B 4430
Affinity Capture-MS Homo sapiens
35 TPRN 286262
Affinity Capture-MS Homo sapiens
36 Eed  
Affinity Capture-MS Mus musculus
37 GTSE1 51512
Affinity Capture-MS Homo sapiens
38 ARPC5L 81873
Affinity Capture-MS Homo sapiens
39 TWF1 5756
Affinity Capture-MS Homo sapiens
40 MYL6 4637
Affinity Capture-MS Homo sapiens
41 WDR1 9948
Affinity Capture-MS Homo sapiens
42 COBL  
Affinity Capture-MS Homo sapiens
43 UNC45A 55898
Affinity Capture-MS Homo sapiens
44 PPP1CA 5499
Affinity Capture-MS Homo sapiens
45 MYO18A 399687
Affinity Capture-MS Homo sapiens
46 KIAA1211  
Affinity Capture-MS Homo sapiens
47 CAPZA1 829
Affinity Capture-MS Homo sapiens
48 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
49 SORBS2  
Affinity Capture-MS Homo sapiens
50 LUZP1 7798
Affinity Capture-MS Homo sapiens
51 DCTN5 84516
Affinity Capture-MS Homo sapiens
52 RAI14 26064
Affinity Capture-MS Homo sapiens
53 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
54 TMOD1  
Affinity Capture-MS Homo sapiens
55 CLTCL1 8218
Affinity Capture-MS Homo sapiens
56 RRAS2 22800
Affinity Capture-MS Homo sapiens
57 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
58 CAMK2G 818
Affinity Capture-MS Homo sapiens
59 MYH9 4627
Affinity Capture-MS Homo sapiens
60 ACTN4 81
Affinity Capture-MS Homo sapiens
61 ARHGAP11A  
Affinity Capture-MS Homo sapiens
62 DCTN1 1639
Affinity Capture-MS Homo sapiens
63 FLNB 2317
Affinity Capture-MS Homo sapiens
64 BMP2K 55589
Affinity Capture-MS Homo sapiens
65 ACTB 60
Affinity Capture-MS Homo sapiens
66 FBXO46  
Affinity Capture-MS Homo sapiens
67 Myo6  
Co-fractionation Mus musculus
68 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
69 PICALM 8301
Affinity Capture-MS Homo sapiens
70 MYL12A 10627
Affinity Capture-MS Homo sapiens
71 ACTG1 71
Affinity Capture-MS Homo sapiens
72 ST5 6764
Affinity Capture-MS Homo sapiens
73 LRCH3 84859
Affinity Capture-MS Homo sapiens
74 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
75 DST 667
Affinity Capture-MS Homo sapiens
76 LIMA1 51474
Affinity Capture-MS Homo sapiens
77 ACTN1 87
Affinity Capture-MS Homo sapiens
78 ITPR2 3709
Affinity Capture-MS Homo sapiens
79 CLINT1 9685
Affinity Capture-MS Homo sapiens
80 ARPC1B 10095
Affinity Capture-MS Homo sapiens
81 DOCK7 85440
Affinity Capture-MS Homo sapiens
82 LMO7 4008
Affinity Capture-MS Homo sapiens
83 Kcna3  
Affinity Capture-MS Mus musculus
84 CTTN 2017
Affinity Capture-MS Homo sapiens
85 SPECC1 92521
Affinity Capture-MS Homo sapiens
86 MYO5A 4644
Affinity Capture-MS Homo sapiens
87 MYO19  
Affinity Capture-MS Homo sapiens
88 NAP1L1 4673
Affinity Capture-MS Homo sapiens
89 HIP1R 9026
Affinity Capture-MS Homo sapiens
90 MYO5C 55930
Affinity Capture-MS Homo sapiens
91 SPTBN1 6711
Affinity Capture-MS Homo sapiens
92 AP2M1 1173
Affinity Capture-MS Homo sapiens
93 Nphp4  
Affinity Capture-MS Mus musculus
94 LZTS2 84445
Affinity Capture-MS Homo sapiens
95 TPM1 7168
Affinity Capture-MS Homo sapiens
96 MTUS1  
Affinity Capture-MS Homo sapiens
97 CORO2A  
Affinity Capture-MS Homo sapiens
98 MYO6 4646
Affinity Capture-MS Homo sapiens
99 FCHO2 115548
Affinity Capture-MS Homo sapiens
100 SEC16A 9919
Affinity Capture-MS Homo sapiens
101 TMOD3 29766
Affinity Capture-MS Homo sapiens
102 CFL2 1073
Affinity Capture-MS Homo sapiens
103 PPFIBP1 8496
Affinity Capture-MS Homo sapiens
104 FLII 2314
Affinity Capture-MS Homo sapiens
105 CLTC 1213
Affinity Capture-MS Homo sapiens
106 MPRIP 23164
Affinity Capture-MS Homo sapiens
107 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
108 LIMCH1 22998
Affinity Capture-MS Homo sapiens
109 Plekhb1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
110 TPM4 7171
Affinity Capture-MS Homo sapiens
111 Fancd2  
Affinity Capture-MS Mus musculus
112 Myo3a  
Co-fractionation Mus musculus
113 GSN 2934
Affinity Capture-MS Homo sapiens
114 ARPC3 10094
Affinity Capture-MS Homo sapiens
115 NEXN 91624
Affinity Capture-MS Homo sapiens
116 SPTAN1 6709
Affinity Capture-MS Homo sapiens
117 MYLK 4638
Affinity Capture-MS Homo sapiens
118 DAB2 1601
Affinity Capture-MS Homo sapiens
119 TRPS1  
Affinity Capture-MS Homo sapiens
120 SVIL 6840
Affinity Capture-MS Homo sapiens
121 SSFA2 6744
Affinity Capture-MS Homo sapiens
122 SPTBN2 6712
Affinity Capture-MS Homo sapiens
123 DENND1A 57706
Affinity Capture-MS Homo sapiens
124 MISP 126353
Affinity Capture-MS Homo sapiens
125 Atxn1  
Affinity Capture-MS Mus musculus
126 Kctd13  
Affinity Capture-MS Mus musculus
127 CAPZA2 830
Affinity Capture-MS Homo sapiens
128 S100A10 6281
Affinity Capture-MS Homo sapiens
129 DCTN2 10540
Affinity Capture-MS Homo sapiens
130 ITPR3 3710
Affinity Capture-MS Homo sapiens
131 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
132 Mettl21e  
Affinity Capture-MS Mus musculus
133 Apc2  
Co-fractionation Mus musculus
134 ACTA1 58
Affinity Capture-MS Homo sapiens
135 AFAP1 60312
Affinity Capture-MS Homo sapiens
136 INF2 64423
Affinity Capture-MS Homo sapiens
137 SYNPO 11346
Affinity Capture-MS Homo sapiens
138 DAPK3 1613
Affinity Capture-MS Homo sapiens
139 FLNA 2316
Affinity Capture-MS Homo sapiens
140 CLTA 1211
Affinity Capture-MS Homo sapiens
141 MYO1E 4643
Affinity Capture-MS Homo sapiens
142 ITPR1 3708
Affinity Capture-MS Homo sapiens
143 KAT6A  
Affinity Capture-MS Homo sapiens
144 GAS2L1 10634
Affinity Capture-MS Homo sapiens
145 SSH2  
Affinity Capture-MS Homo sapiens
146 CORO1C 23603
Affinity Capture-MS Homo sapiens
147 TIMM13 26517
Affinity Capture-MS Homo sapiens
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