Gene description for RAI14
Gene name retinoic acid induced 14
Gene symbol RAI14
Other names/aliases NORPEG
RAI13
Species Homo sapiens
 Database cross references - RAI14
ExoCarta ExoCarta_26064
Vesiclepedia VP_26064
Entrez Gene 26064
HGNC 14873
MIM 606586
UniProt Q9P0K7  
 RAI14 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RAI14
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
Biological Process
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    stress fiber GO:0001725 IEA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cell cortex GO:0005938 IEA
    anchoring junction GO:0070161 IEA
 Experiment description of studies that identified RAI14 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RAI14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Proximity Label-MS Homo sapiens
2 LRSAM1 90678
Affinity Capture-MS Homo sapiens
3 ISG15 9636
Affinity Capture-MS Homo sapiens
4 PPP1CB 5500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
5 RPGRIP1L 23322
Affinity Capture-MS Homo sapiens
6 Tpm1 22003
Affinity Capture-MS Mus musculus
7 CALM3 808
Affinity Capture-MS Homo sapiens
8 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MARCKS 4082
Proximity Label-MS Homo sapiens
10 RPA2 6118
Affinity Capture-MS Homo sapiens
11 PHLPP1  
Proximity Label-MS Homo sapiens
12 FBXO25  
Affinity Capture-MS Homo sapiens
13 ACTC1 70
Proximity Label-MS Homo sapiens
14 DBN1 1627
Affinity Capture-MS Homo sapiens
15 PACSIN2 11252
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 KIF20A 10112
Affinity Capture-MS Homo sapiens
17 MYO5C 55930
Affinity Capture-MS Homo sapiens
18 Actb 11461
Affinity Capture-MS Mus musculus
19 STX4 6810
Proximity Label-MS Homo sapiens
20 ANKRD50 57182
Affinity Capture-MS Homo sapiens
21 PPP1CC 5501
Affinity Capture-MS Homo sapiens
22 SEPT9 10801
Proximity Label-MS Homo sapiens
23 VPS26A 9559
Affinity Capture-MS Homo sapiens
24 CAPZB 832
Affinity Capture-MS Homo sapiens
25 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
26 RDX 5962
Proximity Label-MS Homo sapiens
27 DYRK1A 1859
Affinity Capture-MS Homo sapiens
28 KIF23 9493
Affinity Capture-MS Homo sapiens
29 GAGE5  
Affinity Capture-MS Homo sapiens
30 CALD1 800
Affinity Capture-MS Homo sapiens
31 TRIOBP 11078
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
32 Poc1b  
Affinity Capture-MS Mus musculus
33 PRC1 9055
Affinity Capture-MS Homo sapiens
34 IQGAP1 8826
Affinity Capture-MS Homo sapiens
35 PSMD9 5715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MDC1  
Affinity Capture-MS Homo sapiens
37 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 C11orf52 91894
Proximity Label-MS Homo sapiens
39 Cep76  
Affinity Capture-MS Mus musculus
40 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 STX6 10228
Proximity Label-MS Homo sapiens
42 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FBXW7  
Affinity Capture-MS Homo sapiens
44 RAB35 11021
Proximity Label-MS Homo sapiens
45 BTRC 8945
Affinity Capture-MS Homo sapiens
46 SH3BGRL 6451
Affinity Capture-MS Homo sapiens
47 AIPL1  
Affinity Capture-MS Homo sapiens
48 OCLM  
Affinity Capture-MS Homo sapiens
49 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 Lima1  
Affinity Capture-MS Mus musculus
51 NECAB1  
Affinity Capture-MS Homo sapiens
52 KIF14 9928
Affinity Capture-MS Homo sapiens
53 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 VTN 7448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CHMP4C 92421
Affinity Capture-MS Homo sapiens
56 MYO18A 399687
Affinity Capture-MS Homo sapiens
57 Asap1  
Two-hybrid Mus musculus
58 RBX1 9978
Affinity Capture-MS Homo sapiens
59 OCLN 100506658
Proximity Label-MS Homo sapiens
60 LYN 4067
Proximity Label-MS Homo sapiens
61 MCAM 4162
Proximity Label-MS Homo sapiens
62 PTP4A3  
Affinity Capture-MS Homo sapiens
63 CDH1 999
Proximity Label-MS Homo sapiens
64 CHMP4B 128866
Affinity Capture-MS Homo sapiens
65 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 YAP1 10413
Affinity Capture-MS Homo sapiens
67 MYH9 4627
Affinity Capture-MS Homo sapiens
68 Plk1  
Affinity Capture-MS Mus musculus
69 IFI16 3428
Affinity Capture-MS Homo sapiens
70 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 Calml3  
Affinity Capture-MS Mus musculus
73 Coro1c 23790
Affinity Capture-MS Mus musculus
74 KRT38 8687
Affinity Capture-MS Homo sapiens
75 PRKAR1B  
Affinity Capture-MS Homo sapiens
76 C16orf59 80178
Affinity Capture-MS Homo sapiens
77 FEZ2 9637
Two-hybrid Homo sapiens
78 YWHAE 7531
Affinity Capture-MS Homo sapiens
79 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 TPX2  
Affinity Capture-MS Homo sapiens
81 LIMA1 51474
Affinity Capture-MS Homo sapiens
82 TCP10  
Affinity Capture-MS Homo sapiens
83 BRF1  
Affinity Capture-MS Homo sapiens
84 Myh9 17886
Affinity Capture-MS Mus musculus
85 FURIN 5045
Affinity Capture-MS Homo sapiens
86 RAB7A 7879
Proximity Label-MS Homo sapiens
87 JPH3 57338
Affinity Capture-MS Homo sapiens
88 RAB5A 5868
Proximity Label-MS Homo sapiens
89 ECT2 1894
Affinity Capture-MS Homo sapiens
90 RLIM 51132
Affinity Capture-MS Homo sapiens
91 CTTN 2017
Affinity Capture-MS Homo sapiens
92 MTMR10 54893
Affinity Capture-MS Homo sapiens
93 ERLEC1 27248
Affinity Capture-MS Homo sapiens
94 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 BTF3 689
Affinity Capture-MS Homo sapiens
96 MYO19  
Affinity Capture-MS Homo sapiens
97 RNF138  
Affinity Capture-MS Homo sapiens
98 PACSIN3 29763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 MYO1C 4641
Affinity Capture-MS Homo sapiens
100 TFCP2 7024
Affinity Capture-MS Homo sapiens
101 CDK2 1017
Affinity Capture-MS Homo sapiens
102 SYNPO 11346
Affinity Capture-MS Homo sapiens
103 FOS 2353
Proximity Label-MS Homo sapiens
104 Flnb 286940
Affinity Capture-MS Mus musculus
105 MYC  
Affinity Capture-MS Homo sapiens
106 RPA3 6119
Affinity Capture-MS Homo sapiens
107 PACSIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 DPM2 8818
Affinity Capture-MS Homo sapiens
109 RHOB 388
Proximity Label-MS Homo sapiens
110 Ppp1cb 19046
Affinity Capture-MS Mus musculus
111 TMSB4Y  
Affinity Capture-MS Homo sapiens
112 PARP16 54956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 FLOT1 10211
Proximity Label-MS Homo sapiens
114 MALL  
Affinity Capture-MS Homo sapiens
115 FEZ1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
116 PDLIM7 9260
Affinity Capture-MS Homo sapiens
117 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
118 Tmod3 50875
Affinity Capture-MS Mus musculus
119 ITSN1 6453
Two-hybrid Homo sapiens
120 C6orf201  
Affinity Capture-MS Homo sapiens
121 ZNF746  
Affinity Capture-MS Homo sapiens
122 CXCL6  
Affinity Capture-MS Homo sapiens
123 EZR 7430
Proximity Label-MS Homo sapiens
124 RPA1 6117
Affinity Capture-MS Homo sapiens
125 Myo1c 17913
Affinity Capture-MS Mus musculus
126 LCK 3932
Proximity Label-MS Homo sapiens
127 CAPZA2 830
Affinity Capture-MS Homo sapiens
128 DDX58 23586
Affinity Capture-MS Homo sapiens
129 Mprip  
Affinity Capture-MS Mus musculus
130 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 Myh10 77579
Affinity Capture-MS Mus musculus
132 RNF38  
Affinity Capture-MS Homo sapiens
133 TMEM257  
Affinity Capture-MS Homo sapiens
134 1810055G02Rik  
Affinity Capture-MS Mus musculus
135 LRRK2 120892
Affinity Capture-MS Homo sapiens
136 PCBP1 5093
Proximity Label-MS Homo sapiens
137 FLNA 2316
Affinity Capture-MS Homo sapiens
138 PINK1  
Affinity Capture-MS Homo sapiens
139 RAB11A 8766
Proximity Label-MS Homo sapiens
140 CIT 11113
Affinity Capture-MS Homo sapiens
141 KXD1 79036
Affinity Capture-MS Homo sapiens
142 EPHA2 1969
Proximity Label-MS Homo sapiens
143 SAA1 6288
Affinity Capture-MS Homo sapiens
144 KRAS 3845
Proximity Label-MS Homo sapiens
145 CAV1 857
Proximity Label-MS Homo sapiens
146 UQCR11  
Affinity Capture-MS Homo sapiens
147 UBE2V2 7336
Affinity Capture-MS Homo sapiens
148 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RAI14 is involved
No pathways found





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