Gene description for FURIN
Gene name	furin (paired basic amino acid cleaving enzyme)
Gene symbol	FURIN
Other names/aliases	FUR PACE PCSK3 SPC1
Species	Homo sapiens
Database cross references - FURIN
ExoCarta	ExoCarta_5045
Entrez Gene	5045
HGNC	8568
MIM	136950
UniProt	P09958
FURIN identified in exosomes derived from the following tissue/cell type
Saliva	19199708

Gene ontology annotations for FURIN

Molecular Function     peptide binding GO:0042277 IDA     peptidase activity GO:0008233 IDA     protein binding GO:0005515 IPI     serine-type endopeptidase inhibitor activity GO:0004867 IDA     protease binding GO:0002020 IPI     serine-type endopeptidase activity GO:0004252 IDA     nerve growth factor binding GO:0048406 IDA     endopeptidase activity GO:0004175 IDA     metal ion binding GO:0046872 IEA Biological Process     peptide hormone processing GO:0016486 IDA     post-translational protein modification GO:0043687 TAS     secretion by cell GO:0032940 IDA     negative regulation of low-density lipoprotein particle receptor catabolic process GO:0032804 IDA     protein processing GO:0016485 IMP     signal peptide processing GO:0006465 IDA     extracellular matrix disassembly GO:0022617 TAS     negative regulation of endopeptidase activity GO:0010951 IDA     nerve growth factor production GO:0032902 IDA     regulation of signal transduction GO:0009966 IEA     cell proliferation GO:0008283 IMP     collagen catabolic process GO:0030574 TAS     peptidyl-glutamic acid carboxylation GO:0017187 TAS     viral process GO:0016032 TAS     nerve growth factor processing GO:0032455 TAS     negative regulation of transforming growth factor beta1 production GO:0032911 IMP     regulation of endopeptidase activity GO:0052548 IDA     viral protein processing GO:0019082 TAS     Notch signaling pathway GO:0007219 TAS     peptide biosynthetic process GO:0043043 IDA     proteolysis GO:0006508 TAS     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     regulation of protein catabolic process GO:0042176 IMP     negative regulation of nerve growth factor production GO:0032904 IDA     cellular protein metabolic process GO:0044267 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     extracellular matrix organization GO:0030198 TAS     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IC     virion assembly GO:0019068 TAS     viral life cycle GO:0019058 IEP Subcellular Localization     Golgi lumen GO:0005796 TAS     trans-Golgi network GO:0005802 IDA     integral component of membrane GO:0016021 IEA     plasma membrane GO:0005886 TAS     trans-Golgi network transport vesicle GO:0030140 IDA     membrane GO:0016020 IDA     extracellular space GO:0005615 IDA     extracellular exosome GO:0070062 IDA     membrane raft GO:0045121 IDA     Golgi membrane GO:0000139 TAS     cell surface GO:0009986 IDA