Gene description for RIT1
Gene name Ras-like without CAAX 1
Gene symbol RIT1
Other names/aliases NS8
RIBB
RIT
ROC1
Species Homo sapiens
 Database cross references - RIT1
ExoCarta ExoCarta_6016
Vesiclepedia VP_6016
Entrez Gene 6016
HGNC 10023
MIM 609591
UniProt Q92963  
 RIT1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RIT1
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IDA
    G protein activity GO:0003925 IEA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IDA
    GDP binding GO:0019003 IBA
Biological Process
    signal transduction GO:0007165 TAS
    Ras protein signal transduction GO:0007265 IBA
    Ras protein signal transduction GO:0007265 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified RIT1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RIT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CFAP20 29105
Negative Genetic Homo sapiens
2 ITGB1 3688
Negative Genetic Homo sapiens
3 EIF3A 8661
Negative Genetic Homo sapiens
4 RRN3  
Negative Genetic Homo sapiens
5 NUF2  
Negative Genetic Homo sapiens
6 RAD51  
Negative Genetic Homo sapiens
7 DGCR14  
Negative Genetic Homo sapiens
8 DNAJC11 55735
Negative Genetic Homo sapiens
9 SEC61A1 29927
Negative Genetic Homo sapiens
10 VMP1 81671
Negative Genetic Homo sapiens
11 TRAPPC1 58485
Negative Genetic Homo sapiens
12 ATP6V1B2 526
Negative Genetic Homo sapiens
13 EIF3C 8663
Negative Genetic Homo sapiens
14 PRPF8 10594
Negative Genetic Homo sapiens
15 ATXN7L2  
Negative Genetic Homo sapiens
16 COA5  
Negative Genetic Homo sapiens
17 SRPK2 6733
Biochemical Activity Homo sapiens
18 UTP11L  
Negative Genetic Homo sapiens
19 DYNC1I2 1781
Negative Genetic Homo sapiens
20 RCL1 10171
Negative Genetic Homo sapiens
21 ARPC4 10093
Negative Genetic Homo sapiens
22 HNRNPK 3190
Negative Genetic Homo sapiens
23 EIF2B2 8892
Negative Genetic Homo sapiens
24 LOC101060321  
Negative Genetic Homo sapiens
25 DHPS 1725
Negative Genetic Homo sapiens
26 BRCA1 672
Negative Genetic Homo sapiens
27 GOLGA6A  
Negative Genetic Homo sapiens
28 SNRNP40 9410
Negative Genetic Homo sapiens
29 MAD2L1BP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
30 RNGTT 8732
Negative Genetic Homo sapiens
31 CSE1L 1434
Negative Genetic Homo sapiens
32 PPIAL4A 653505
Negative Genetic Homo sapiens
33 VHL  
Affinity Capture-Western Homo sapiens
Negative Genetic Homo sapiens
34 INTS1 26173
Negative Genetic Homo sapiens
35 PRPF40A 55660
Negative Genetic Homo sapiens
36 TAF1  
Negative Genetic Homo sapiens
37 UQCRC2 7385
Negative Genetic Homo sapiens
38 RPF2 84154
Negative Genetic Homo sapiens
39 SBDS 51119
Negative Genetic Homo sapiens
40 LSM10  
Negative Genetic Homo sapiens
41 DPF1  
Negative Genetic Homo sapiens
42 RPL28 6158
Negative Genetic Homo sapiens
43 NOL8  
Negative Genetic Homo sapiens
44 DDX23 9416
Negative Genetic Homo sapiens
45 SPDYE6  
Negative Genetic Homo sapiens
46 RHEB 6009
Negative Genetic Homo sapiens
47 NPIPB9  
Negative Genetic Homo sapiens
48 DHX33  
Negative Genetic Homo sapiens
49 CRNKL1 51340
Negative Genetic Homo sapiens
50 DARS 1615
Negative Genetic Homo sapiens
51 GTF2E2  
Negative Genetic Homo sapiens
52 GFPT1 2673
Negative Genetic Homo sapiens
53 PPP6C 5537
Negative Genetic Homo sapiens
54 CCS 9973
Negative Genetic Homo sapiens
55 SF3B1 23451
Negative Genetic Homo sapiens
56 RNF8  
Negative Genetic Homo sapiens
57 PRMT5 10419
Negative Genetic Homo sapiens
58 KIF23 9493
Negative Genetic Homo sapiens
59 NAMPT 10135
Negative Genetic Homo sapiens
60 METAP2 10988
Negative Genetic Homo sapiens
61 PTPN23 25930
Negative Genetic Homo sapiens
62 RPL18 6141
Negative Genetic Homo sapiens
63 CGB1  
Negative Genetic Homo sapiens
64 PSMD12 5718
Negative Genetic Homo sapiens
65 CGB8  
Negative Genetic Homo sapiens
66 ELOF1  
Negative Genetic Homo sapiens
67 RPL12 6136
Negative Genetic Homo sapiens
68 MARCH5  
Negative Genetic Homo sapiens
69 FXN  
Negative Genetic Homo sapiens
70 MRPL57  
Negative Genetic Homo sapiens
71 RUVBL1 8607
Negative Genetic Homo sapiens
72 GSPT1 2935
Negative Genetic Homo sapiens
73 NUS1  
Negative Genetic Homo sapiens
74 POLRMT 5442
Negative Genetic Homo sapiens
75 EIF3E 3646
Negative Genetic Homo sapiens
76 LRR1  
Negative Genetic Homo sapiens
77 DCAF15  
Negative Genetic Homo sapiens
78 EXOSC4 54512
Negative Genetic Homo sapiens
79 AMD1  
Negative Genetic Homo sapiens
80 PSMG1 8624
Negative Genetic Homo sapiens
81 POLR2C 5432
Negative Genetic Homo sapiens
82 NDUFAB1 4706
Negative Genetic Homo sapiens
83 DHODH 1723
Negative Genetic Homo sapiens
84 PSMC1 5700
Negative Genetic Homo sapiens
85 BCS1L 617
Negative Genetic Homo sapiens
86 FPGS 2356
Negative Genetic Homo sapiens
87 GPS1 2873
Negative Genetic Homo sapiens
88 PFDN6 10471
Negative Genetic Homo sapiens
89 GAPDH 2597
Negative Genetic Homo sapiens
90 SRSF6 6431
Negative Genetic Homo sapiens
91 SOD1 6647
Negative Genetic Homo sapiens
92 EEF1A1 1915
Negative Genetic Homo sapiens
93 USPL1  
Negative Genetic Homo sapiens
94 KIF14 9928
Negative Genetic Homo sapiens
95 GALE 2582
Negative Genetic Homo sapiens
96 RPS14 6208
Negative Genetic Homo sapiens
97 RBMX 27316
Negative Genetic Homo sapiens
98 LARS 51520
Negative Genetic Homo sapiens
99 HEXIM1 10614
Negative Genetic Homo sapiens
100 AURKA 6790
Negative Genetic Homo sapiens
101 WBP4  
Negative Genetic Homo sapiens
102 TCP1 6950
Negative Genetic Homo sapiens
103 PGS1 9489
Negative Genetic Homo sapiens
104 SNRNP70 6625
Negative Genetic Homo sapiens
105 C7orf26  
Negative Genetic Homo sapiens
106 SBNO1 55206
Negative Genetic Homo sapiens
107 RFC5 5985
Negative Genetic Homo sapiens
108 PSMA4 5685
Negative Genetic Homo sapiens
109 MEPCE 56257
Negative Genetic Homo sapiens
110 SAE1 10055
Negative Genetic Homo sapiens
111 XRCC5 7520
Negative Genetic Homo sapiens
112 LOC100507462  
Negative Genetic Homo sapiens
113 SNRNP25  
Negative Genetic Homo sapiens
114 AES 166
Negative Genetic Homo sapiens
115 UBE2I 7329
Negative Genetic Homo sapiens
116 TUFM 7284
Negative Genetic Homo sapiens
117 COPB1 1315
Negative Genetic Homo sapiens
118 PSMG2 56984
Negative Genetic Homo sapiens
119 TRMT61A 115708
Negative Genetic Homo sapiens
120 SUPT16H 11198
Negative Genetic Homo sapiens
121 HDAC7  
Negative Genetic Homo sapiens
122 NOL12 79159
Negative Genetic Homo sapiens
123 CIRH1A 84916
Negative Genetic Homo sapiens
124 CARM1 10498
Negative Genetic Homo sapiens
125 CLCC1 23155
Negative Genetic Homo sapiens
126 NUDC 10726
Negative Genetic Homo sapiens
127 CKAP5 9793
Negative Genetic Homo sapiens
128 RPL31 6160
Negative Genetic Homo sapiens
129 RAD1  
Negative Genetic Homo sapiens
130 OR4F17  
Negative Genetic Homo sapiens
131 NOC4L 79050
Negative Genetic Homo sapiens
132 DDX55  
Negative Genetic Homo sapiens
133 TGS1  
Negative Genetic Homo sapiens
134 WDR43 23160
Negative Genetic Homo sapiens
135 GINS1  
Negative Genetic Homo sapiens
136 NOB1  
Negative Genetic Homo sapiens
137 SNRPD1 6632
Negative Genetic Homo sapiens
138 MED25  
Negative Genetic Homo sapiens
139 SDAD1  
Negative Genetic Homo sapiens
140 SCUBE3 222663
Negative Genetic Homo sapiens
141 VPS25 84313
Negative Genetic Homo sapiens
142 SON 6651
Negative Genetic Homo sapiens
143 TFAM 7019
Negative Genetic Homo sapiens
144 AHCTF1 25909
Negative Genetic Homo sapiens
145 NCL 4691
Negative Genetic Homo sapiens
146 VPS18 57617
Negative Genetic Homo sapiens
147 UBA1 7317
Negative Genetic Homo sapiens
148 GTPBP4 23560
Negative Genetic Homo sapiens
149 PDCD7  
Negative Genetic Homo sapiens
150 PFAS 5198
Negative Genetic Homo sapiens
151 NRF1 4899
Negative Genetic Homo sapiens
152 VCP 7415
Negative Genetic Homo sapiens
153 CD3EAP  
Negative Genetic Homo sapiens
154 RPL27 6155
Negative Genetic Homo sapiens
155 PTN  
Two-hybrid Homo sapiens
156 C17orf104  
Negative Genetic Homo sapiens
157 ISCA1  
Negative Genetic Homo sapiens
158 DTL  
Negative Genetic Homo sapiens
159 BRF1  
Negative Genetic Homo sapiens
160 GTF3C3 9330
Negative Genetic Homo sapiens
161 RARS2  
Negative Genetic Homo sapiens
162 EARS2  
Negative Genetic Homo sapiens
163 WBSCR16  
Negative Genetic Homo sapiens
164 GMPPB 29925
Negative Genetic Homo sapiens
165 PAFAH1B1 5048
Negative Genetic Homo sapiens
166 UFC1 51506
Negative Genetic Homo sapiens
167 MRPS12  
Negative Genetic Homo sapiens
168 MRTO4 51154
Negative Genetic Homo sapiens
169 NUBP2 10101
Negative Genetic Homo sapiens
170 KCNC3 3748
Negative Genetic Homo sapiens
171 HSPE1 3336
Negative Genetic Homo sapiens
172 UBE2F  
Negative Genetic Homo sapiens
173 POLD3  
Negative Genetic Homo sapiens
174 KCMF1 56888
Negative Genetic Homo sapiens
175 ATP6V1D 51382
Negative Genetic Homo sapiens
176 TMEM199  
Negative Genetic Homo sapiens
177 ATP6AP2 10159
Negative Genetic Homo sapiens
178 TOMM22 56993
Negative Genetic Homo sapiens
179 SHQ1  
Negative Genetic Homo sapiens
180 EBNA1BP2 10969
Negative Genetic Homo sapiens
181 DCPS 28960
Negative Genetic Homo sapiens
182 POLR2D  
Negative Genetic Homo sapiens
183 EIF4E 1977
Negative Genetic Homo sapiens
184 EPRS 2058
Negative Genetic Homo sapiens
185 DHX37  
Negative Genetic Homo sapiens
186 RBBP4 5928
Negative Genetic Homo sapiens
187 KTI12 112970
Negative Genetic Homo sapiens
188 STRAP 11171
Negative Genetic Homo sapiens
189 YTHDC1  
Negative Genetic Homo sapiens
190 FBXW11  
Negative Genetic Homo sapiens
191 TUBGCP4 27229
Negative Genetic Homo sapiens
192 SRF  
Negative Genetic Homo sapiens
193 IST1 9798
Negative Genetic Homo sapiens
194 MFAP1  
Negative Genetic Homo sapiens
195 RPL17 6139
Negative Genetic Homo sapiens
196 SS18L2  
Negative Genetic Homo sapiens
197 RPA3 6119
Negative Genetic Homo sapiens
198 LSM3 27258
Negative Genetic Homo sapiens
199 RPP40 10799
Negative Genetic Homo sapiens
200 DLST 1743
Negative Genetic Homo sapiens
201 ROMO1 140823
Negative Genetic Homo sapiens
202 PES1 23481
Negative Genetic Homo sapiens
203 PHF5A 84844
Negative Genetic Homo sapiens
204 DDX54 79039
Negative Genetic Homo sapiens
205 EIF3CL 728689
Negative Genetic Homo sapiens
206 MBTPS2  
Negative Genetic Homo sapiens
207 ACTL6B  
Affinity Capture-MS Homo sapiens
208 PPAT 5471
Negative Genetic Homo sapiens
209 EIF2B1 1967
Negative Genetic Homo sapiens
210 SMC6  
Negative Genetic Homo sapiens
211 MARS2 92935
Negative Genetic Homo sapiens
212 NPIPB6  
Negative Genetic Homo sapiens
213 UTP3 57050
Negative Genetic Homo sapiens
214 LYRM4 57128
Negative Genetic Homo sapiens
215 MED14  
Negative Genetic Homo sapiens
216 GNL3 26354
Negative Genetic Homo sapiens
217 HAUS3  
Negative Genetic Homo sapiens
218 BIRC5  
Negative Genetic Homo sapiens
219 RPS16 6217
Negative Genetic Homo sapiens
220 PPIAL4E 730262
Negative Genetic Homo sapiens
221 U2SURP 23350
Negative Genetic Homo sapiens
222 DDX46 9879
Negative Genetic Homo sapiens
223 RGL3  
Two-hybrid Homo sapiens
224 PAXBP1  
Negative Genetic Homo sapiens
225 YBX1 4904
Negative Genetic Homo sapiens
226 NUDT21 11051
Negative Genetic Homo sapiens
227 GLS 2744
Negative Genetic Homo sapiens
228 RPS27A 6233
Negative Genetic Homo sapiens
229 THOC3  
Negative Genetic Homo sapiens
230 TUBGCP2 10844
Negative Genetic Homo sapiens
231 CTR9 9646
Negative Genetic Homo sapiens
232 ORC3  
Negative Genetic Homo sapiens
233 GRB2 2885
Negative Genetic Homo sapiens
234 POLE  
Negative Genetic Homo sapiens
235 NSF 4905
Negative Genetic Homo sapiens
236 RPL6 6128
Negative Genetic Homo sapiens
237 RRS1 23212
Negative Genetic Homo sapiens
238 RBM25 58517
Negative Genetic Homo sapiens
239 RGPD8  
Negative Genetic Homo sapiens
240 NAA20  
Negative Genetic Homo sapiens
241 ARMC7  
Negative Genetic Homo sapiens
242 STRN4 29888
Negative Genetic Homo sapiens
243 TIPIN  
Negative Genetic Homo sapiens
244 HSPE1-MOB4  
Negative Genetic Homo sapiens
245 POLR3H  
Negative Genetic Homo sapiens
246 CDC37 11140
Negative Genetic Homo sapiens
247 RRP1 8568
Negative Genetic Homo sapiens
248 KPNA6 23633
Negative Genetic Homo sapiens
249 SKP1 6500
Negative Genetic Homo sapiens
250 EIF3I 8668
Negative Genetic Homo sapiens
251 CDC6  
Negative Genetic Homo sapiens