Gene description for IK
Gene name IK cytokine, down-regulator of HLA II
Gene symbol IK
Other names/aliases CSA2
RED
Species Homo sapiens
 Database cross references - IK
ExoCarta ExoCarta_3550
Vesiclepedia VP_3550
Entrez Gene 3550
HGNC 5958
MIM 600549
UniProt Q13123  
 IK identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for IK
Molecular Function
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
Biological Process
    cell-cell signaling GO:0007267 TAS
    immune response GO:0006955 TAS
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 IDA
    extracellular space GO:0005615 TAS
 Experiment description of studies that identified IK in exosomes
1
Experiment ID 834
ISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
ISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for IK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUP62 23636
Two-hybrid Homo sapiens
2 PFN2 5217
Two-hybrid Homo sapiens
3 HTATIP  
Two-hybrid Homo sapiens
4 CHD3 1107
Two-hybrid Homo sapiens
5 Supt5h  
Two-hybrid Mus musculus
6 FANCC 2176
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IK is involved
No pathways found





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