Gene description for FRA10AC1
Gene name fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
Gene symbol FRA10AC1
Other names/aliases C10orf4
F26C11.1-like
FRA10A
Species Homo sapiens
 Database cross references - FRA10AC1
ExoCarta ExoCarta_118924
Vesiclepedia VP_118924
Entrez Gene 118924
HGNC 1162
MIM 608866
UniProt Q70Z53  
 FRA10AC1 identified in sEVs derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for FRA10AC1
Molecular Function
    protein binding GO:0005515 IPI
    phosphatase activity GO:0016791 IBA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IMP
Subcellular Localization
    nucleus GO:0005634 IMP
 Experiment description of studies that identified FRA10AC1 in sEVs
1
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FRA10AC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 LPPR4  
Two-hybrid Homo sapiens
3 SNX27 81609
Affinity Capture-MS Homo sapiens
4 SF3B2 10992
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
5 DGCR14  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
6 THOC1 9984
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 WASF3 10810
Affinity Capture-MS Homo sapiens
8 CHERP 10523
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
9 CWC27 10283
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 XPO1 7514
Affinity Capture-MS Homo sapiens
11 PSENEN  
Affinity Capture-MS Homo sapiens
12 PITHD1 57095
Affinity Capture-MS Homo sapiens
13 TRIM41 90933
Two-hybrid Homo sapiens
14 FUOM  
Affinity Capture-MS Homo sapiens
15 UBA1 7317
Affinity Capture-MS Homo sapiens
16 TTC14  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 SAP30BP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 SGOL1  
Affinity Capture-MS Homo sapiens
19 SLC25A1 6576
Cross-Linking-MS (XL-MS) Homo sapiens
20 MAP3K12  
Reconstituted Complex Homo sapiens
21 PRPF3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 CCDC155  
Two-hybrid Homo sapiens
23 PRPF40A 55660
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 ADPRHL2 54936
Two-hybrid Homo sapiens
25 VPS29 51699
Two-hybrid Homo sapiens
26 FGF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 IK 3550
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
28 MFAP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 EEF1D 1936
Two-hybrid Homo sapiens
30 MSL1 339287
Affinity Capture-MS Homo sapiens
31 MOB2 81532
Two-hybrid Homo sapiens
32 ZCCHC10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 LENG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ALOX5AP  
Affinity Capture-MS Homo sapiens
35 GLRX3 10539
Two-hybrid Homo sapiens
36 CLIC1 1192
Co-fractionation Homo sapiens
37 C7orf25  
Two-hybrid Homo sapiens
38 OIP5  
Affinity Capture-MS Homo sapiens
39 MTUS2 23281
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ZNF830  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 GDPD2  
Two-hybrid Homo sapiens
42 NKAP 79576
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 U2AF1 7307
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FRA10AC1 is involved
No pathways found





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