Gene description for PITHD1
Gene name PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
Gene symbol PITHD1
Other names/aliases C1orf128
HT014
TXNL1CL
Species Homo sapiens
 Database cross references - PITHD1
ExoCarta ExoCarta_57095
Vesiclepedia VP_57095
Entrez Gene 57095
HGNC 25022
UniProt Q9GZP4  
 PITHD1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PITHD1
Biological Process
    spermatid development GO:0007286 IEA
    penetration of zona pellucida GO:0007341 IEA
    positive regulation of megakaryocyte differentiation GO:0045654 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    regulation of proteasomal protein catabolic process GO:0061136 IEA
    penetration of cumulus oophorus GO:0061956 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IDA
    sperm cytoplasmic droplet GO:0097598 IEA
 Experiment description of studies that identified PITHD1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PITHD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 RECQL5  
Affinity Capture-MS Homo sapiens
3 SNX27 81609
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 RRM2 6241
Affinity Capture-MS Homo sapiens
6 CDC73  
Two-hybrid Homo sapiens
7 CLDND1 56650
Affinity Capture-MS Homo sapiens
8 PRNP 5621
Affinity Capture-MS Homo sapiens
9 EGLN3  
Affinity Capture-MS Homo sapiens
10 YWHAB 7529
Co-fractionation Homo sapiens
11 AURKA 6790
Affinity Capture-MS Homo sapiens
12 SLK 9748
Co-fractionation Homo sapiens
13 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
14 ZDHHC19  
Affinity Capture-MS Homo sapiens
15 EEF1A2 1917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DUSP13  
Affinity Capture-MS Homo sapiens
17 LRTM1  
Affinity Capture-MS Homo sapiens
18 DHX38 9785
Co-fractionation Homo sapiens
19 FXR2 9513
Affinity Capture-MS Homo sapiens
20 ANKRD39  
Affinity Capture-MS Homo sapiens
21 FRA10AC1 118924
Affinity Capture-MS Homo sapiens
22 HSPA1A 3303
Affinity Capture-MS Homo sapiens
23 WDR59 79726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FNTB 2342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 METTL9 51108
Affinity Capture-MS Homo sapiens
26 RPRD1A  
Affinity Capture-MS Homo sapiens
27 CETN2 1069
Co-fractionation Homo sapiens
28 PRMT1 3276
Affinity Capture-MS Homo sapiens
29 STX17 55014
Affinity Capture-MS Homo sapiens
30 MGEA5 10724
Co-fractionation Homo sapiens
31 KDM5C  
Co-fractionation Homo sapiens
32 WISP2 8839
Affinity Capture-MS Homo sapiens
33 CRMP1 1400
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FMR1NB  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PITHD1 is involved
No pathways found





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