Gene description for FNTB
Gene name farnesyltransferase, CAAX box, beta
Gene symbol FNTB
Other names/aliases FPTB
Species Homo sapiens
 Database cross references - FNTB
ExoCarta ExoCarta_2342
Vesiclepedia VP_2342
Entrez Gene 2342
HGNC 3785
MIM 134636
UniProt P49356  
 FNTB identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FNTB
Molecular Function
    protein farnesyltransferase activity GO:0004660 IBA
    protein farnesyltransferase activity GO:0004660 IDA
    protein farnesyltransferase activity GO:0004660 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
Biological Process
    lipid metabolic process GO:0006629 IEA
    protein farnesylation GO:0018343 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
    microtubule associated complex GO:0005875 IDA
    protein farnesyltransferase complex GO:0005965 IBA
    protein farnesyltransferase complex GO:0005965 IDA
 Experiment description of studies that identified FNTB in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FNTB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMKV 79012
Affinity Capture-MS Homo sapiens
2 FAM131B  
Affinity Capture-MS Homo sapiens
3 NPLOC4 55666
Co-fractionation Homo sapiens
4 CCDC24  
Two-hybrid Homo sapiens
5 AGXT  
Two-hybrid Homo sapiens
6 SNX33 257364
Affinity Capture-MS Homo sapiens
7 EN1  
Affinity Capture-MS Homo sapiens
8 CAPN8 388743
Affinity Capture-MS Homo sapiens
9 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PTP4A1 7803
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 DHX57 90957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 HOOK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PARK2  
Affinity Capture-MS Homo sapiens
14 SMG9 56006
Two-hybrid Homo sapiens
15 DYRK1A 1859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 UBE2O 63893
Affinity Capture-MS Homo sapiens
17 CHCHD2  
Affinity Capture-MS Homo sapiens
18 DUSP14 11072
Affinity Capture-MS Homo sapiens
19 APOL6  
Two-hybrid Homo sapiens
20 PTP4A2 8073
Affinity Capture-MS Homo sapiens
21 C10orf71  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 KRT31 3881
Affinity Capture-MS Homo sapiens
23 ENPP1 5167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TP53TG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ARNT2  
Affinity Capture-MS Homo sapiens
26 PRNP 5621
Affinity Capture-MS Homo sapiens
27 SMPD2 6610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PPM1B 5495
Affinity Capture-MS Homo sapiens
29 CPA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ACTA2 59
Affinity Capture-MS Homo sapiens
31 KRT34  
Affinity Capture-MS Homo sapiens
32 TLX3  
Two-hybrid Homo sapiens
33 ZNF691  
Affinity Capture-MS Homo sapiens
34 KRBA1  
Two-hybrid Homo sapiens
35 CAST 831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RRAS2 22800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PGGT1B 5229
Affinity Capture-MS Homo sapiens
38 DCAF7 10238
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RPL27A 6157
Affinity Capture-MS Homo sapiens
40 CAPN1 823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 NDUFAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ARFGAP1 55738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 LRRC15 131578
Affinity Capture-MS Homo sapiens
44 KCNS3 3790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 MINK1 50488
Affinity Capture-MS Homo sapiens
46 MRM1  
Affinity Capture-MS Homo sapiens
47 ATP6V0D1 9114
Co-fractionation Homo sapiens
48 RPL10 6134
Affinity Capture-MS Homo sapiens
49 AURKAIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 UGGT1 56886
Co-fractionation Homo sapiens
51 MRPS11  
Affinity Capture-MS Homo sapiens
52 PITHD1 57095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 LMNB2 84823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 EGFR 1956
Negative Genetic Homo sapiens
55 HOOK3 84376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 FNTA 2339
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 NAP1L1 4673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 DGKZ  
Affinity Capture-MS Homo sapiens
59 AVP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SELENBP1 8991
Affinity Capture-MS Homo sapiens
61 TFPI2 7980
Affinity Capture-MS Homo sapiens
62 ATPAF2 91647
Two-hybrid Homo sapiens
63 LPIN2  
Affinity Capture-MS Homo sapiens
64 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 GRIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PAFAH1B1 5048
Co-fractionation Homo sapiens
67 UHRF1BP1L 23074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 FAM53C 51307
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 SPDL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HDAC6 10013
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
71 TROAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CENPF 1063
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CAPNS1 826
Affinity Capture-MS Homo sapiens
74 OVOL2  
Affinity Capture-MS Homo sapiens
75 CWC15  
Affinity Capture-MS Homo sapiens
76 AUP1 550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 FAM117B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 RPL23AP32 56969
Affinity Capture-MS Homo sapiens
80 DSG4 147409
Affinity Capture-MS Homo sapiens
81 YKT6 10652
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 GLYR1 84656
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 RPL23A 6147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 KRAS 3845
Negative Genetic Homo sapiens
85 P2RX2  
Affinity Capture-MS Homo sapiens
86 LBHD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 CCR1  
Affinity Capture-MS Homo sapiens
88 RPA3 6119
Proximity Label-MS Homo sapiens
89 RPRD1A  
Co-fractionation Homo sapiens
90 RPL17 6139
Affinity Capture-MS Homo sapiens
91 CAPN2 824
Affinity Capture-MS Homo sapiens
92 INTU  
Affinity Capture-MS Homo sapiens
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