Gene description for DSG4
Gene name desmoglein 4
Gene symbol DSG4
Other names/aliases CDGF13
CDHF13
HYPT6
LAH
Species Homo sapiens
 Database cross references - DSG4
ExoCarta ExoCarta_147409
Vesiclepedia VP_147409
Entrez Gene 147409
HGNC 21307
MIM 607892
UniProt Q86SJ6  
 DSG4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DSG4
Molecular Function
    calcium ion binding GO:0005509 IBA
Biological Process
    hair follicle development GO:0001942 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    keratinocyte differentiation GO:0030216 IEA
    BMP signaling pathway GO:0030509 IEA
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    cornified envelope GO:0001533 TAS
    plasma membrane GO:0005886 TAS
    desmosome GO:0030057 IBA
 Experiment description of studies that identified DSG4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DSG4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F11R 50848
Affinity Capture-MS Homo sapiens
2 LAIR2  
Affinity Capture-MS Homo sapiens
3 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TEX35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TGIF2LX  
Affinity Capture-MS Homo sapiens
6 RAB9B 51209
Affinity Capture-MS Homo sapiens
7 MCCC1 56922
Affinity Capture-MS Homo sapiens
8 ST6GALNAC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MRPS18C  
Affinity Capture-MS Homo sapiens
11 SRSF10 10772
Affinity Capture-MS Homo sapiens
12 PTDSS1 9791
Affinity Capture-MS Homo sapiens
13 FBXO3  
Affinity Capture-MS Homo sapiens
14 USP6NL 9712
Affinity Capture-MS Homo sapiens
15 IL31RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 OTULIN 90268
Affinity Capture-MS Homo sapiens
17 DUSP14 11072
Affinity Capture-MS Homo sapiens
18 HERC3 8916
Affinity Capture-MS Homo sapiens
19 CPLX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 APIP 51074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PFN2 5217
Affinity Capture-MS Homo sapiens
22 OAZ3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FOXP2 93986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SGOL2 151246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SAMHD1 25939
Affinity Capture-MS Homo sapiens
28 COASY 80347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 DHRS12  
Affinity Capture-MS Homo sapiens
30 LACC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ITGAD  
Affinity Capture-MS Homo sapiens
32 P2RY8  
Affinity Capture-MS Homo sapiens
33 DTNBP1  
Affinity Capture-MS Homo sapiens
34 PEMT  
Affinity Capture-MS Homo sapiens
35 BLOC1S5 63915
Affinity Capture-MS Homo sapiens
36 C1R 715
Affinity Capture-MS Homo sapiens
37 LRCH1 23143
Affinity Capture-MS Homo sapiens
38 RDH13  
Affinity Capture-MS Homo sapiens
39 IQUB  
Affinity Capture-MS Homo sapiens
40 ANXA9  
Affinity Capture-MS Homo sapiens
41 UGT1A9  
Affinity Capture-MS Homo sapiens
42 APBA1  
Affinity Capture-MS Homo sapiens
43 OR51E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 GEMIN7  
Affinity Capture-MS Homo sapiens
45 B3GALNT1 8706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DKK2  
Affinity Capture-MS Homo sapiens
47 FSTL1 11167
Affinity Capture-MS Homo sapiens
48 POLG2  
Affinity Capture-MS Homo sapiens
49 FBXL4 26235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 FAM153C  
Affinity Capture-MS Homo sapiens
51 RPN2 6185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RASGRP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SPARCL1  
Affinity Capture-MS Homo sapiens
55 LPCAT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 NR3C1 2908
Proximity Label-MS Homo sapiens
57 THNSL1 79896
Affinity Capture-MS Homo sapiens
58 PNMA2  
Affinity Capture-MS Homo sapiens
59 PLD5  
Affinity Capture-MS Homo sapiens
60 TFG 10342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SYP  
Affinity Capture-MS Homo sapiens
62 HEPN1  
Affinity Capture-MS Homo sapiens
63 FOS 2353
Affinity Capture-MS Homo sapiens
64 SMAD9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RAB11B 9230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ZNF597  
Affinity Capture-MS Homo sapiens
67 FNTB 2342
Affinity Capture-MS Homo sapiens
68 SETDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 SGIP1  
Affinity Capture-MS Homo sapiens
70 CCDC173 129881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 DYM  
Affinity Capture-MS Homo sapiens
72 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 NPAP1  
Affinity Capture-MS Homo sapiens
74 NSMAF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PYHIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 YIF1B 90522
Affinity Capture-MS Homo sapiens
77 CXorf66  
Affinity Capture-MS Homo sapiens
78 SPANXC  
Affinity Capture-MS Homo sapiens
79 RARA 5914
Affinity Capture-MS Homo sapiens
80 ZMYM6NB  
Affinity Capture-MS Homo sapiens
81 DRD3  
Affinity Capture-MS Homo sapiens
82 SYT16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 ISCA2 122961
Affinity Capture-MS Homo sapiens
84 BTC  
Affinity Capture-MS Homo sapiens
85 GSC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 RYK 6259
Affinity Capture-MS Homo sapiens
87 CAPZA2 830
Affinity Capture-MS Homo sapiens
88 ELMOD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 REEP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 DOLPP1  
Affinity Capture-MS Homo sapiens
91 ANKH 56172
Affinity Capture-MS Homo sapiens
92 CACUL1  
Affinity Capture-MS Homo sapiens
93 KDELR2 11014
Affinity Capture-MS Homo sapiens
94 EIF4B 1975
Affinity Capture-MS Homo sapiens
95 MAPK9 5601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 FOXN3 1112
Affinity Capture-MS Homo sapiens
97 SRMS  
Affinity Capture-MS Homo sapiens
98 BHLHE23  
Affinity Capture-MS Homo sapiens
99 RAC1 5879
Affinity Capture-MS Homo sapiens
100 MTL5  
Affinity Capture-MS Homo sapiens
101 ZMAT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 PMM1 5372
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SKA2  
Affinity Capture-MS Homo sapiens
104 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
105 POPDC2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DSG4 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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