Gene description for MCCC1
Gene name methylcrotonoyl-CoA carboxylase 1 (alpha)
Gene symbol MCCC1
Other names/aliases MCC-B
MCCA
Species Homo sapiens
 Database cross references - MCCC1
ExoCarta ExoCarta_56922
Entrez Gene 56922
HGNC 6936
MIM 609010
UniProt Q96RQ3  
 MCCC1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for MCCC1
Molecular Function
    biotin carboxylase activity GO:0004075 IEA
    biotin binding GO:0009374 NAS
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    methylcrotonoyl-CoA carboxylase activity GO:0004485 NAS
    metal ion binding GO:0046872 IEA
Biological Process
    leucine catabolic process GO:0006552 NAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
    vitamin metabolic process GO:0006766 TAS
    biotin metabolic process GO:0006768 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    branched-chain amino acid catabolic process GO:0009083 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    mitochondrial inner membrane GO:0005743 IEA
 Experiment description of studies that identified MCCC1 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MCCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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