Gene description for SUCLA2
Gene name succinate-CoA ligase, ADP-forming, beta subunit
Gene symbol SUCLA2
Other names/aliases A-BETA
MTDPS5
SCS-betaA
Species Homo sapiens
 Database cross references - SUCLA2
ExoCarta ExoCarta_8803
Entrez Gene 8803
HGNC 11448
MIM 603921
UniProt Q9P2R7  
 SUCLA2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SUCLA2
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    succinate-CoA ligase (ADP-forming) activity GO:0004775 TAS
Biological Process
    succinyl-CoA pathway GO:0006781 NAS
    tricarboxylic acid cycle GO:0006099 TAS
    succinate metabolic process GO:0006105 IEA
    succinyl-CoA metabolic process GO:0006104 TAS
    cellular metabolic process GO:0044237 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified SUCLA2 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SUCLA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ALAS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SUCLA2 is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here