Gene description for LONP2
Gene name lon peptidase 2, peroxisomal
Gene symbol LONP2
Other names/aliases LONP
LONPL
Species Homo sapiens
 Database cross references - LONP2
ExoCarta ExoCarta_83752
Vesiclepedia VP_83752
Entrez Gene 83752
HGNC 20598
UniProt Q86WA8  
 LONP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LONP2
Molecular Function
    protease binding GO:0002020 IPI
    ATP-dependent peptidase activity GO:0004176 IEA
    serine-type endopeptidase activity GO:0004252 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    peptidase activity GO:0008233 IDA
    ATP hydrolysis activity GO:0016887 IEA
    enzyme binding GO:0019899 IPI
Biological Process
    protein quality control for misfolded or incompletely synthesized proteins GO:0006515 IEA
    protein targeting to peroxisome GO:0006625 IBA
    protein targeting to peroxisome GO:0006625 IMP
    peroxisome organization GO:0007031 NAS
    response to organic cyclic compound GO:0014070 IEA
    protein processing GO:0016485 IBA
    protein processing GO:0016485 IMP
    protein import into peroxisome matrix GO:0016558 IEA
    regulation of fatty acid beta-oxidation GO:0031998 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    peroxisome GO:0005777 IDA
    peroxisomal matrix GO:0005782 IBA
    peroxisomal matrix GO:0005782 TAS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified LONP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LONP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 PCDHA8  
Affinity Capture-MS Homo sapiens
4 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LIMK1 3984
Affinity Capture-MS Homo sapiens
6 MTMR10 54893
Affinity Capture-MS Homo sapiens
7 FBXW11  
Affinity Capture-MS Homo sapiens
8 IL17A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RETNLB  
Affinity Capture-MS Homo sapiens
10 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
11 RNF181  
Affinity Capture-MS Homo sapiens
12 WWOX 51741
Affinity Capture-MS Homo sapiens
13 RSPH9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 WNK1 65125
Affinity Capture-MS Homo sapiens
15 C4BPA 722
Affinity Capture-MS Homo sapiens
16 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
17 PCDHA3  
Affinity Capture-MS Homo sapiens
18 PARK2  
Affinity Capture-MS Homo sapiens
19 IGFBP4 3487
Affinity Capture-MS Homo sapiens
20 SUCLA2 8803
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 IGH 3492
Affinity Capture-MS Homo sapiens
22 OS9 10956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MKI67  
Affinity Capture-MS Homo sapiens
24 PCDHA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
27 DCN 1634
Affinity Capture-MS Homo sapiens
28 RB1CC1 9821
Affinity Capture-MS Homo sapiens
29 WWP2 11060
Affinity Capture-MS Homo sapiens
30 MAPK6  
Affinity Capture-MS Homo sapiens
31 CDC16 8881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 LINC00266-1  
Affinity Capture-MS Homo sapiens
33 WWC1  
Affinity Capture-MS Homo sapiens
34 TMOD3 29766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PCDHA4 56144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PCDHA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NEU2  
Affinity Capture-MS Homo sapiens
38 PEX5 5830
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
39 OLFML2B 25903
Affinity Capture-MS Homo sapiens
40 AMOT  
Affinity Capture-MS Homo sapiens
41 HSPA12A 259217
Affinity Capture-MS Homo sapiens
42 AGPS 8540
Proximity Label-MS Homo sapiens
43 LYPD2  
Affinity Capture-MS Homo sapiens
44 MAP7D2 256714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PCDHA11  
Affinity Capture-MS Homo sapiens
46 NXT1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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