Gene description for PCDHA4
Gene name protocadherin alpha 4
Gene symbol PCDHA4
Other names/aliases CNR1
CNRN1
CRNR1
PCDH-ALPHA4
Species Homo sapiens
 Database cross references - PCDHA4
ExoCarta ExoCarta_56144
Vesiclepedia VP_56144
Entrez Gene 56144
HGNC 8670
MIM 606310
UniProt Q9UN74  
 PCDHA4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PCDHA4
Molecular Function
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISS
Biological Process
    cell adhesion GO:0007155 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    nervous system development GO:0007399 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified PCDHA4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCDHA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP3K6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PCDHA8  
Affinity Capture-MS Homo sapiens
3 APLP1 333
Two-hybrid Homo sapiens
4 POMT1 10585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CCDC90B  
Two-hybrid Homo sapiens
6 C14orf1 11161
Two-hybrid Homo sapiens
7 MAP7 9053
Affinity Capture-MS Homo sapiens
8 C1orf43 25912
Affinity Capture-MS Homo sapiens
9 EEF1A1 1915
Two-hybrid Homo sapiens
10 C1orf27 54953
Affinity Capture-MS Homo sapiens
11 TP53 7157
Two-hybrid Homo sapiens
12 PNPT1 87178
Affinity Capture-MS Homo sapiens
13 TMEM223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 EIF2AK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GDF9 2661
Two-hybrid Homo sapiens
16 CNNM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TLE1 7088
Two-hybrid Homo sapiens
18 UBQLN1 29979
Two-hybrid Homo sapiens
19 PCDHA7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PCDHGC3 5098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CLSTN1 22883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM39A  
Affinity Capture-MS Homo sapiens
23 LONP2 83752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SETDB1  
Two-hybrid Homo sapiens
25 PCDHA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PCDHA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DNMT3A 1788
Affinity Capture-MS Homo sapiens
28 LRIF1  
Two-hybrid Homo sapiens
29 SP4  
Affinity Capture-MS Homo sapiens
30 LTBP1 4052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 UBB 7314
Affinity Capture-MS Homo sapiens
32 RBM48  
Two-hybrid Homo sapiens
33 DDX11 1663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DNMT3B  
Affinity Capture-MS Homo sapiens
35 GAPDH 2597
Two-hybrid Homo sapiens
36 PCDHA11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 IGSF21  
Two-hybrid Homo sapiens
38 PCDHGA10  
Affinity Capture-MS Homo sapiens
39 PCDHA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 UNC119 9094
Two-hybrid Homo sapiens
41 UFSP2 55325
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SGTA 6449
Two-hybrid Homo sapiens
43 ANAPC4 29945
Affinity Capture-MS Homo sapiens
44 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TCL1A  
Affinity Capture-MS Homo sapiens
46 COG5 10466
Affinity Capture-MS Homo sapiens
47 SLC10A7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PCDHA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RBSN 64145
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 NMU  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 KIAA0922  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCDHA4 is involved
No pathways found





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