Gene description for PCDHGC3
Gene name protocadherin gamma subfamily C, 3
Gene symbol PCDHGC3
Other names/aliases PC43
PCDH-GAMMA-C3
PCDH2
Species Homo sapiens
 Database cross references - PCDHGC3
ExoCarta ExoCarta_5098
Vesiclepedia VP_5098
Entrez Gene 5098
HGNC 8716
MIM 603627
UniProt Q9UN70  
 PCDHGC3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PCDHGC3
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    nervous system development GO:0007399 IEA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 NAS
    negative regulation of neuron apoptotic process GO:0043524 IEA
    synapse organization GO:0050808 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    membrane GO:0016020 NAS
 Experiment description of studies that identified PCDHGC3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCDHGC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RYK 6259
Affinity Capture-MS Homo sapiens
2 PTPRG 5793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PCDHGA4  
Affinity Capture-MS Homo sapiens
4 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PCDHGA6 56109
Affinity Capture-MS Homo sapiens
6 SIRT6  
Affinity Capture-MS Homo sapiens
7 GAPDHS 26330
Affinity Capture-MS Homo sapiens
8 HRAS 3265
Affinity Capture-MS Homo sapiens
9 RXFP1  
Affinity Capture-MS Homo sapiens
10 C2orf48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GNAQ 2776
Affinity Capture-MS Homo sapiens
12 CDCA3 83461
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GNAZ 2781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 HGD 3081
Two-hybrid Homo sapiens
15 PCDH12 51294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SPTBN4 57731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SPSB4  
Affinity Capture-MS Homo sapiens
19 CNTN1 1272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CLEC4A  
Affinity Capture-MS Homo sapiens
21 PCDHB6  
Affinity Capture-MS Homo sapiens
22 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
23 CEACAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GAP43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MFSD3  
Two-hybrid Homo sapiens
26 EEPD1 80820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 APP 351
Reconstituted Complex Homo sapiens
28 TRIM54  
Two-hybrid Homo sapiens
29 PCDHA4 56144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PCDHGB2  
Affinity Capture-MS Homo sapiens
31 PAG1 55824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CHRNA9  
Affinity Capture-MS Homo sapiens
33 ERICH5  
Affinity Capture-MS Homo sapiens
34 CDH1 999
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PACSIN3 29763
Affinity Capture-MS Homo sapiens
36 FYN 2534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 UBTD2 92181
Affinity Capture-MS Homo sapiens
38 NTRK1 4914
Affinity Capture-MS Homo sapiens
39 PCDHGB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 XAGE1B  
Affinity Capture-MS Homo sapiens
41 AHNAK 79026
Affinity Capture-MS Homo sapiens
42 GRTP1 79774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CD109 135228
Affinity Capture-MS Homo sapiens
45 SRC 6714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PROCR 10544
Affinity Capture-MS Homo sapiens
47 NRN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CDH16  
Affinity Capture-MS Homo sapiens
49 CDH17 1015
Affinity Capture-MS Homo sapiens
50 YES1 7525
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCDHGC3 is involved
No pathways found





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