Gene description for HGD
Gene name homogentisate 1,2-dioxygenase
Gene symbol HGD
Other names/aliases AKU
HGO
Species Homo sapiens
 Database cross references - HGD
ExoCarta ExoCarta_3081
Entrez Gene 3081
HGNC 4892
MIM 607474
UniProt Q93099  
 HGD identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for HGD
Molecular Function
    homogentisate 1,2-dioxygenase activity GO:0004411 EXP
    metal ion binding GO:0046872 IEA
Biological Process
    tyrosine catabolic process GO:0006572 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    L-phenylalanine catabolic process GO:0006559 TAS
    small molecule metabolic process GO:0044281 TAS
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified HGD in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for HGD
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HGD is involved
PathwayEvidenceSource
Phenylalanine and tyrosine catabolism TAS Reactome





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