Gene description for CLDN7
Gene name claudin 7
Gene symbol CLDN7
Other names/aliases CEPTRL2
CLDN-7
CPETRL2
Hs.84359
claudin-1
Species Homo sapiens
 Database cross references - CLDN7
ExoCarta ExoCarta_1366
Entrez Gene 1366
HGNC 2049
MIM 609131
UniProt O95471  
 CLDN7 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Hepatocytes 26054723    
 Gene ontology annotations for CLDN7
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISS
Biological Process
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 ISS
    positive regulation of defense response to virus by host GO:0002230 IMP
Subcellular Localization
    basolateral plasma membrane GO:0016323 IEA
    lateral plasma membrane GO:0016328 IEA
    bicellular tight junction GO:0005923 ISS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CLDN7 in exosomes
1
Experiment ID 21
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CLDN7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TJP1 7082
Invitro Homo sapiens
2 PEPP-2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CLDN7 is involved
PathwayEvidenceSource
Tight junction interactions TAS Reactome





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