Gene description for JAGN1
Gene name jagunal homolog 1 (Drosophila)
Gene symbol JAGN1
Other names/aliases GL009
SCN6
Species Homo sapiens
 Database cross references - JAGN1
ExoCarta ExoCarta_84522
Vesiclepedia VP_84522
Entrez Gene 84522
HGNC 26926
MIM 616012
UniProt Q8N5M9  
 JAGN1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for JAGN1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    neutrophil mediated immunity GO:0002446 IEA
    exocytosis GO:0006887 TAS
    endoplasmic reticulum organization GO:0007029 IBA
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 IBA
    vesicle-mediated transport GO:0016192 IMP
    neutrophil differentiation GO:0030223 IMP
    granulocyte colony-stimulating factor signaling pathway GO:0038158 IBA
    granulocyte colony-stimulating factor signaling pathway GO:0038158 IMP
    defense response to fungus GO:0050832 IEA
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 IEA
    neutrophil migration GO:1990266 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
 Experiment description of studies that identified JAGN1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for JAGN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Two-hybrid Homo sapiens
2 F11R 50848
Two-hybrid Homo sapiens
3 TSNARE1  
Two-hybrid Homo sapiens
4 VTI1B 10490
Two-hybrid Homo sapiens
5 VAPA 9218
Two-hybrid Homo sapiens
6 SACM1L 22908
Two-hybrid Homo sapiens
7 FRMD3  
Two-hybrid Homo sapiens
8 SMIM1 388588
Two-hybrid Homo sapiens
9 BNIP1 662
Two-hybrid Homo sapiens
10 FAM26F  
Two-hybrid Homo sapiens
11 GOSR2 9570
Two-hybrid Homo sapiens
12 NINJ2  
Two-hybrid Homo sapiens
13 CD79A  
Two-hybrid Homo sapiens
14 APP 351
Reconstituted Complex Homo sapiens
15 SLC12A4 6560
Affinity Capture-MS Homo sapiens
16 COX20  
Two-hybrid Homo sapiens
17 FIS1 51024
Two-hybrid Homo sapiens
18 STX1A 6804
Two-hybrid Homo sapiens
19 TMEM65 157378
Two-hybrid Homo sapiens
20 VKORC1 79001
Two-hybrid Homo sapiens
21 C4orf3  
Two-hybrid Homo sapiens
22 GIMAP1  
Two-hybrid Homo sapiens
23 STX8 9482
Two-hybrid Homo sapiens
24 TIMM23 100287932
Two-hybrid Homo sapiens
25 SLAMF6 114836
Two-hybrid Homo sapiens
26 FCRL4  
Two-hybrid Homo sapiens
27 SERP1 27230
Two-hybrid Homo sapiens
28 LPAR3  
Two-hybrid Homo sapiens
29 GIMAP5  
Two-hybrid Homo sapiens
30 FCRL2  
Two-hybrid Homo sapiens
31 CCDC47 57003
Affinity Capture-MS Homo sapiens
32 SMAGP  
Two-hybrid Homo sapiens
33 BET1 10282
Two-hybrid Homo sapiens
34 FCGR1A  
Two-hybrid Homo sapiens
35 KIR2DL3  
Two-hybrid Homo sapiens
36 TMIE  
Two-hybrid Homo sapiens
37 FAM177A1 283635
Two-hybrid Homo sapiens
38 TMEM106C 79022
Two-hybrid Homo sapiens
39 KIR3DL3  
Two-hybrid Homo sapiens
40 DDOST 1650
Co-fractionation Homo sapiens
41 TREX1  
Two-hybrid Homo sapiens
42 CLDN7 1366
Two-hybrid Homo sapiens
43 TMEM14B  
Two-hybrid Homo sapiens
44 HTATIP2 10553
Two-hybrid Homo sapiens
45 CLEC7A  
Two-hybrid Homo sapiens
46 CCL4L2  
Two-hybrid Homo sapiens
47 CYP4F2  
Two-hybrid Homo sapiens
48 TMEM100 55273
Two-hybrid Homo sapiens
49 VSIG4  
Two-hybrid Homo sapiens
50 VAMP2 6844
Two-hybrid Homo sapiens
51 SMIM19  
Two-hybrid Homo sapiens
52 SCAMP2 10066
Co-fractionation Homo sapiens
53 TMEM243  
Two-hybrid Homo sapiens
54 PDZK1IP1 10158
Two-hybrid Homo sapiens
55 RPN1 6184
Proximity Label-MS Homo sapiens
56 STX5 6811
Two-hybrid Homo sapiens
57 ARL13B 200894
Two-hybrid Homo sapiens
58 DNAJC30  
Two-hybrid Homo sapiens
59 STOML3 161003
Two-hybrid Homo sapiens
60 LHFPL5  
Two-hybrid Homo sapiens
61 C17orf62 79415
Two-hybrid Homo sapiens
62 MFF 56947
Two-hybrid Homo sapiens
63 GJB5  
Two-hybrid Homo sapiens
64 CDIPT 10423
Two-hybrid Homo sapiens
65 TMEM52B 120939
Two-hybrid Homo sapiens
66 KCNA1  
Two-hybrid Homo sapiens
67 FNDC9  
Two-hybrid Homo sapiens
68 BMP10  
Two-hybrid Homo sapiens
69 VAPB 9217
Two-hybrid Homo sapiens
70 CANX 821
Affinity Capture-MS Homo sapiens
71 PPAP2C 8612
Two-hybrid Homo sapiens
72 C14orf1 11161
Two-hybrid Homo sapiens
73 BTNL9  
Two-hybrid Homo sapiens
74 RTP2  
Two-hybrid Homo sapiens
75 MTIF3  
Two-hybrid Homo sapiens
76 ERGIC3 51614
Two-hybrid Homo sapiens
77 TMEM128  
Two-hybrid Homo sapiens
78 ICMT  
Two-hybrid Homo sapiens
79 NR3C1 2908
Proximity Label-MS Homo sapiens
80 SLC34A2 10568
Two-hybrid Homo sapiens
81 FKBP8 23770
Two-hybrid Homo sapiens
82 CCDC155  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 HSD17B13  
Two-hybrid Homo sapiens
84 FXYD6  
Two-hybrid Homo sapiens
85 RIPK4  
Affinity Capture-MS Homo sapiens
86 CREB3L1  
Two-hybrid Homo sapiens
87 TMEM242  
Two-hybrid Homo sapiens
88 GPR152  
Two-hybrid Homo sapiens
89 FAM209A 200232
Two-hybrid Homo sapiens
90 FAM105A  
Two-hybrid Homo sapiens
91 EDA2R  
Two-hybrid Homo sapiens
92 TMEM237 65062
Two-hybrid Homo sapiens
93 RPA3 6119
Proximity Label-MS Homo sapiens
94 CMTM5  
Two-hybrid Homo sapiens
95 PSCA 8000
Two-hybrid Homo sapiens
96 SLC12A6 9990
Affinity Capture-MS Homo sapiens
97 BNIP3 664
Two-hybrid Homo sapiens
98 TMEM207  
Two-hybrid Homo sapiens
99 UBE2J1 51465
Two-hybrid Homo sapiens
100 NRG1 3084
Two-hybrid Homo sapiens
101 IFNGR2  
Two-hybrid Homo sapiens
102 TMED10 10972
Affinity Capture-MS Homo sapiens
103 PLP1 5354
Two-hybrid Homo sapiens
104 TECR 9524
Co-fractionation Homo sapiens
105 SLC16A2  
Two-hybrid Homo sapiens
106 GP2  
Two-hybrid Homo sapiens
107 EHHADH 1962
Two-hybrid Homo sapiens
108 TNFSF14  
Two-hybrid Homo sapiens
109 TMEM120B  
Two-hybrid Homo sapiens
110 EBP  
Two-hybrid Homo sapiens
111 IL3RA  
Two-hybrid Homo sapiens
112 VDAC2 7417
Co-fractionation Homo sapiens
113 CLEC12B  
Two-hybrid Homo sapiens
114 BSND  
Two-hybrid Homo sapiens
115 RNMTL1  
Two-hybrid Homo sapiens
116 STX3 6809
Two-hybrid Homo sapiens
117 LEMD1  
Two-hybrid Homo sapiens
118 GPR37L1  
Two-hybrid Homo sapiens
119 FAM134C 162427
Two-hybrid Homo sapiens
120 TMEM199  
Two-hybrid Homo sapiens
121 SERBP1 26135
Affinity Capture-MS Homo sapiens
122 IER3IP1 51124
Two-hybrid Homo sapiens
123 RAB5C 5878
Proximity Label-MS Homo sapiens
124 GOLM1 51280
Two-hybrid Homo sapiens
125 VDAC3 7419
Co-fractionation Homo sapiens
126 CLEC4D  
Two-hybrid Homo sapiens
127 ELOVL4  
Two-hybrid Homo sapiens
128 SEC61A1 29927
Co-fractionation Homo sapiens
129 VAMP5 10791
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which JAGN1 is involved
No pathways found





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