Gene description for STX1A
Gene name syntaxin 1A (brain)
Gene symbol STX1A
Other names/aliases HPC-1
P35-1
STX1
SYN1A
Species Homo sapiens
 Database cross references - STX1A
ExoCarta ExoCarta_6804
Vesiclepedia VP_6804
Entrez Gene 6804
HGNC 11433
MIM 186590
UniProt Q16623  
 STX1A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for STX1A
Molecular Function
    SNARE binding GO:0000149 IBA
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    calcium channel inhibitor activity GO:0019855 IEA
    chloride channel inhibitor activity GO:0019869 IDA
    kinase binding GO:0019900 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    positive regulation of neurotransmitter secretion GO:0001956 IEA
    intracellular protein transport GO:0006886 IBA
    exocytosis GO:0006887 IBA
    vesicle fusion GO:0006906 IBA
    positive regulation of norepinephrine secretion GO:0010701 ISS
    regulation of synaptic vesicle priming GO:0010807 IEA
    synaptic vesicle exocytosis GO:0016079 IDA
    protein sumoylation GO:0016925 IDA
    calcium-ion regulated exocytosis GO:0017156 IEA
    insulin secretion GO:0030073 IEA
    secretion by cell GO:0032940 IDA
    positive regulation of catecholamine secretion GO:0033605 ISS
    positive regulation of calcium ion-dependent exocytosis GO:0045956 ISS
    vesicle docking GO:0048278 IBA
    synaptic vesicle endocytosis GO:0048488 IDA
    regulation of insulin secretion GO:0050796 TAS
    positive regulation of excitatory postsynaptic potential GO:2000463 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    voltage-gated potassium channel complex GO:0008076 ISS
    endomembrane system GO:0012505 IBA
    axon GO:0030424 IEA
    synaptic vesicle membrane GO:0030672 IEA
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 IDA
    SNARE complex GO:0031201 TAS
    nuclear membrane GO:0031965 IEA
    neuron projection GO:0043005 IDA
    synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044 IEA
 Experiment description of studies that identified STX1A in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for STX1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 GPM6A 2823
Affinity Capture-MS Homo sapiens
3 LOC100507537  
Two-hybrid Homo sapiens
4 TRDMT1  
Two-hybrid Homo sapiens
5 CCSER2 54462
Two-hybrid Homo sapiens
6 TSNARE1  
Two-hybrid Homo sapiens
7 VTI1B 10490
Two-hybrid Homo sapiens
8 SNAP23 8773
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 VAPA 9218
Affinity Capture-Western Homo sapiens
10 NAPA 8775
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 MIP  
Two-hybrid Homo sapiens
12 SLC6A2  
Affinity Capture-Western Homo sapiens
13 STXBP6 29091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SMIM1 388588
Two-hybrid Homo sapiens
15 TMEM14C 51522
Two-hybrid Homo sapiens
16 EMD 2010
Two-hybrid Homo sapiens
17 PPAPDC1A  
Two-hybrid Homo sapiens
18 AIG1  
Two-hybrid Homo sapiens
19 VAMP2 6844
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
20 NINJ2  
Two-hybrid Homo sapiens
21 C4orf3  
Two-hybrid Homo sapiens
22 STX4 6810
Two-hybrid Homo sapiens
23 STX11 8676
Two-hybrid Homo sapiens
24 MAL  
Two-hybrid Homo sapiens
25 ABI3 51225
Two-hybrid Homo sapiens
26 APEX1 328
Affinity Capture-RNA Homo sapiens
27 CPLX2 10814
Affinity Capture-Western Homo sapiens
28 STX1A 6804
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 PSMA3 5684
Two-hybrid Homo sapiens
30 ZNF440  
Two-hybrid Homo sapiens
31 PPAPDC2  
Two-hybrid Homo sapiens
32 TMEM222 84065
Two-hybrid Homo sapiens
33 ZNF490  
Two-hybrid Homo sapiens
34 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 GIMAP1  
Two-hybrid Homo sapiens
36 C2orf82  
Two-hybrid Homo sapiens
37 STX8 9482
Two-hybrid Homo sapiens
38 SLC6A5  
Affinity Capture-Western Homo sapiens
39 ETNK2  
Two-hybrid Homo sapiens
40 OIP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 BLOC1S6  
Two-hybrid Homo sapiens
42 SERP1 27230
Two-hybrid Homo sapiens
43 GIMAP5  
Two-hybrid Homo sapiens
44 STX6 10228
Two-hybrid Homo sapiens
45 CPLX1 10815
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
46 SCNN1A  
Affinity Capture-Western Homo sapiens
47 BET1 10282
Two-hybrid Homo sapiens
48 SYTL4 94121
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
49 ZNF136  
Two-hybrid Homo sapiens
50 TCEANC  
Two-hybrid Homo sapiens
51 EBAG9 9166
Two-hybrid Homo sapiens
52 STX12 23673
Two-hybrid Homo sapiens
53 TMEM254  
Two-hybrid Homo sapiens
54 TNF  
Two-hybrid Homo sapiens
55 pnut 35801
Affinity Capture-Western Drosophila melanogaster
56 CHMP4C 92421
Affinity Capture-MS Homo sapiens
57 TMEM120A 83862
Two-hybrid Homo sapiens
58 PPP1CA 5499
Affinity Capture-Western Homo sapiens
59 TSGA10IP  
Two-hybrid Homo sapiens
60 RAB3IL1 5866
Two-hybrid Homo sapiens
61 KIFC3 3801
Two-hybrid Homo sapiens
62 BNIP1 662
Two-hybrid Homo sapiens
63 CDK5 1020
Reconstituted Complex Homo sapiens
64 JAGN1 84522
Two-hybrid Homo sapiens
65 FAM9C  
Affinity Capture-MS Homo sapiens
66 TMEM100 55273
Two-hybrid Homo sapiens
67 SNAP47 116841
Two-hybrid Homo sapiens
68 AGTRAP 57085
Two-hybrid Homo sapiens
69 UBE2I 7329
Two-hybrid Homo sapiens
70 APOL2 23780
Two-hybrid Homo sapiens
71 CD81 975
Two-hybrid Homo sapiens
72 VAMP1 6843
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
73 ATP6V1B1 525
Reconstituted Complex Homo sapiens
74 STX5 6811
Two-hybrid Homo sapiens
75 ARL13B 200894
Two-hybrid Homo sapiens
76 SNAP29 9342
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
77 TMEM60  
Two-hybrid Homo sapiens
78 UBTFL1  
Two-hybrid Homo sapiens
79 SCNN1G  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
80 TMEM128  
Two-hybrid Homo sapiens
81 DNAAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 RNF40 9810
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
83 CYB5B 80777
Two-hybrid Homo sapiens
84 TMEM199  
Two-hybrid Homo sapiens
85 UPK1B 7348
Two-hybrid Homo sapiens
86 STXBP5 134957
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
87 VAPB 9217
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
88 C14orf1 11161
Two-hybrid Homo sapiens
89 VAMP8 8673
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
90 ZFPL1 7542
Two-hybrid Homo sapiens
91 RTP2  
Two-hybrid Homo sapiens
92 STXBP1 6812
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
93 TMEM41A  
Two-hybrid Homo sapiens
94 TXLNB  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
95 AOC3 8639
Two-hybrid Homo sapiens
96 CASC4 113201
Two-hybrid Homo sapiens
97 ZNF835  
Two-hybrid Homo sapiens
98 ZNF250  
Two-hybrid Homo sapiens
99 ZNF557  
Two-hybrid Homo sapiens
100 AQP3  
Two-hybrid Homo sapiens
101 SMIM3  
Two-hybrid Homo sapiens
102 GOSR2 9570
Two-hybrid Homo sapiens
103 NRM 11270
Two-hybrid Homo sapiens
104 SYP  
Affinity Capture-Western Homo sapiens
105 SERP2  
Two-hybrid Homo sapiens
106 Stxbp1 25558
Affinity Capture-Luminescence Rattus norvegicus
Two-hybrid Rattus norvegicus
107 Sep1 33114
Affinity Capture-Western Drosophila melanogaster
108 ZNF12  
Two-hybrid Homo sapiens
109 Snap25  
Two-hybrid Rattus norvegicus
Two-hybrid Rattus norvegicus
110 RMDN2 151393
Two-hybrid Homo sapiens
111 SUMO1P1  
Two-hybrid Homo sapiens
112 HAX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 STX10 8677
Two-hybrid Homo sapiens
114 NKG7  
Two-hybrid Homo sapiens
115 ZNF696  
Two-hybrid Homo sapiens
116 DDX49 54555
Two-hybrid Homo sapiens
117 MALL  
Two-hybrid Homo sapiens
118 SLC6A4 6532
Affinity Capture-Western Homo sapiens
119 STX2 2054
Two-hybrid Homo sapiens
120 TXLNA 200081
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
121 C1GALT1 56913
Two-hybrid Homo sapiens
122 ZNF707  
Two-hybrid Homo sapiens
123 VSTM4 196740
Two-hybrid Homo sapiens
124 CMTM7  
Two-hybrid Homo sapiens
125 ZNF785  
Two-hybrid Homo sapiens
126 STX16 8675
Two-hybrid Homo sapiens
127 PLP1 5354
Two-hybrid Homo sapiens
128 Snap23 20619
Two-hybrid Mus musculus
Two-hybrid Mus musculus
129 ZNF441  
Two-hybrid Homo sapiens
130 ANKRD46 157567
Two-hybrid Homo sapiens
131 CDC37 11140
Two-hybrid Homo sapiens
132 FAM3C 10447
Two-hybrid Homo sapiens
133 VAMP4 8674
Two-hybrid Homo sapiens
134 PNLIPRP1  
Two-hybrid Homo sapiens
135 Htt  
Affinity Capture-MS Mus musculus
136 SNAP25 6616
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
137 BTN2A2  
Two-hybrid Homo sapiens
138 SLC6A9 6536
Affinity Capture-Western Homo sapiens
139 SLC6A3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
140 SCNN1B 6338
Affinity Capture-Western Homo sapiens
141 CLN6  
Two-hybrid Homo sapiens
142 SLC6A1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
143 NAPB 63908
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
144 MMGT1 93380
Two-hybrid Homo sapiens
145 VAMP7 6845
Reconstituted Complex Homo sapiens
146 PLN  
Two-hybrid Homo sapiens
147 APOL3  
Two-hybrid Homo sapiens
148 STX3 6809
Two-hybrid Homo sapiens
149 KCNB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
150 AARD  
Two-hybrid Homo sapiens
151 SEC22A  
Two-hybrid Homo sapiens
152 DGUOK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 ZNF479  
Two-hybrid Homo sapiens
154 CDR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 VAMP5 10791
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
156 PGAP2  
Two-hybrid Homo sapiens
157 CFTR 1080
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
158 VIM 7431
Two-hybrid Homo sapiens
159 UNC13B 10497
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
160 CLEC1A  
Two-hybrid Homo sapiens
161 SYT1 6857
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
162 CXCL16 58191
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which STX1A is involved
PathwayEvidenceSource
Acetylcholine Neurotransmitter Release Cycle TAS Reactome
Bacterial Infection Pathways TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Dopamine Neurotransmitter Release Cycle TAS Reactome
GABA synthesis, release, reuptake and degradation TAS Reactome
Glutamate Neurotransmitter Release Cycle TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane IEA Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane TAS Reactome
Insulin processing IEA Reactome
Integration of energy metabolism IEA Reactome
LGI-ADAM interactions TAS Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Neurexins and neuroligins IEA Reactome
Neuronal System TAS Reactome
Neuronal System IEA Reactome
Neurotoxicity of clostridium toxins TAS Reactome
Neurotransmitter release cycle TAS Reactome
Norepinephrine Neurotransmitter Release Cycle TAS Reactome
Other interleukin signaling TAS Reactome
Peptide hormone metabolism IEA Reactome
Protein localization IEA Reactome
Protein localization TAS Reactome
Protein-protein interactions at synapses IEA Reactome
Regulation of insulin secretion IEA Reactome
Sensory Perception IEA Reactome
Sensory processing of sound IEA Reactome
Sensory processing of sound by inner hair cells of the cochlea IEA Reactome
Serotonin Neurotransmitter Release Cycle TAS Reactome
Signaling by Interleukins TAS Reactome
Toxicity of botulinum toxin type C (botC) TAS Reactome
Transmission across Chemical Synapses TAS Reactome
Uptake and actions of bacterial toxins TAS Reactome





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