Gene description for Snap23
Gene name synaptosomal-associated protein 23
Gene symbol Snap23
Other names/aliases 23kDa
AA408749
SNAP-23
Sndt
Syndet
Species Mus musculus
 Database cross references - Snap23
ExoCarta ExoCarta_20619
Vesiclepedia VP_20619
Entrez Gene 20619
UniProt O09044  
 Snap23 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snap23
Molecular Function
    SNAP receptor activity GO:0005484 ISO
    protein binding GO:0005515 IPI
    syntaxin binding GO:0019905 ISO
Biological Process
    exocytosis GO:0006887 IMP
    synaptic vesicle fusion to presynaptic membrane GO:0031629 IBA
    transport GO:0006810 IEA
    histamine secretion by mast cell GO:0002553 ISO
    regulation of exocytosis GO:0017157 ISO
    synaptic vesicle priming GO:0016082 IBA
    vesicle-mediated transport GO:0016192 ISO
    membrane fusion GO:0061025 ISO
    protein complex assembly GO:0006461 ISO
    protein transport GO:0015031 ISO
Subcellular Localization
    terminal bouton GO:0043195 ISO
    neuron projection GO:0043005 IEA
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    mast cell granule GO:0042629 ISO
    synapse GO:0045202 IEA
    SNARE complex GO:0031201 ISO
    cell GO:0005623 IMP
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 IEA
    azurophil granule GO:0042582 ISO
    nucleoplasm GO:0005654 ISO
    specific granule GO:0042581 ISO
    cell junction GO:0030054 IEA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified Snap23 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snap23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX1A 6804
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 STX4 6810
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 STX3 6809
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 STX2 2054
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Snap23 is involved
PathwayEvidenceSource
Clathrin derived vesicle budding IEA Reactome
Translocation of GLUT4 to the plasma membrane IEA Reactome





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