Gene description for IKBKB
Gene name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Gene symbol IKBKB
Other names/aliases IKK-beta
IKK2
IKKB
IMD15
NFKBIKB
Species Homo sapiens
 Database cross references - IKBKB
ExoCarta ExoCarta_3551
Vesiclepedia VP_3551
Entrez Gene 3551
HGNC 5960
MIM 603258
UniProt O14920  
 IKBKB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for IKBKB
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 EXP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    IkappaB kinase activity GO:0008384 IDA
    IkappaB kinase activity GO:0008384 TAS
    protein kinase binding GO:0019901 IPI
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    protein heterodimerization activity GO:0046982 IDA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    scaffold protein binding GO:0097110 IDA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
    transferrin receptor binding GO:1990459 IPI
Biological Process
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 NAS
    inflammatory response GO:0006954 TAS
    canonical NF-kappaB signal transduction GO:0007249 IDA
    canonical NF-kappaB signal transduction GO:0007249 IMP
    canonical NF-kappaB signal transduction GO:0007249 TAS
    response to virus GO:0009615 TAS
    regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 TAS
    peptidyl-serine phosphorylation GO:0018105 IDA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IBA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IMP
    regulation of toll-like receptor signaling pathway GO:0034121 TAS
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    regulation of phosphorylation GO:0042325 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    innate immune response GO:0045087 TAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    T cell receptor signaling pathway GO:0050852 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    stress-activated MAPK cascade GO:0051403 TAS
    protein maturation GO:0051604 IDA
    interleukin-1-mediated signaling pathway GO:0070498 IMP
    interleukin-1-mediated signaling pathway GO:0070498 TAS
    cellular response to tumor necrosis factor GO:0071356 IDA
    protein localization to plasma membrane GO:0072659 IMP
    regulation of establishment of endothelial barrier GO:1903140 IMP
    negative regulation of bicellular tight junction assembly GO:1903347 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    IkappaB kinase complex GO:0008385 IBA
    IkappaB kinase complex GO:0008385 IPI
    IkappaB kinase complex GO:0008385 TAS
    cytoplasmic side of plasma membrane GO:0009898 ISS
    CD40 receptor complex GO:0035631 ISS
    membrane raft GO:0045121 IEA
 Experiment description of studies that identified IKBKB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IKBKB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Co-fractionation Homo sapiens
2 TNFAIP3 7128
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
3 HOMER3 9454
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 TRAPPC9 83696
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 TNIP1 10318
Co-fractionation Homo sapiens
6 CUEDC2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 MACROD1 28992
Affinity Capture-MS Homo sapiens
8 PRKCD 5580
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 DHCR24 1718
Affinity Capture-MS Homo sapiens
10 RPL30 6156
Co-fractionation Homo sapiens
11 REL 5966
Co-fractionation Homo sapiens
12 SLC25A13 10165
Affinity Capture-MS Homo sapiens
13 MARCH2  
Affinity Capture-Western Homo sapiens
14 BRCA1 672
Negative Genetic Homo sapiens
15 TAB1 10454
Affinity Capture-Western Homo sapiens
16 HSP90AB1 3326
Co-localization Homo sapiens
Co-fractionation Homo sapiens
17 ATM 472
Affinity Capture-Western Homo sapiens
18 SLC25A22  
Affinity Capture-MS Homo sapiens
19 TERF2IP 54386
Affinity Capture-Western Homo sapiens
20 NLRP2  
Affinity Capture-Western Homo sapiens
21 RIPK1 8737
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
22 STAP2 55620
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
23 PRKDC 5591
Biochemical Activity Homo sapiens
24 LRPPRC 10128
Co-fractionation Homo sapiens
25 NFKB1 4790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
26 MRFAP1L1  
Affinity Capture-MS Homo sapiens
27 TSC1 7248
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
28 LRRC14 9684
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 PELI1 57162
Biochemical Activity Homo sapiens
30 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
31 TFAP2C 7022
Two-hybrid Homo sapiens
32 USP18  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 MUC1 4582
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
34 ERC1 23085
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
36 MAPK14 1432
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 NCOA3  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
38 CSF2RA  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Co-localization Homo sapiens
39 IKBKE 9641
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
40 FAF1 11124
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
41 BIRC3 330
Co-localization Homo sapiens
42 NLRX1 79671
Affinity Capture-Western Homo sapiens
43 CALCOCO2  
Affinity Capture-Western Homo sapiens
44 CUL1 8454
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
45 BTRC 8945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 CSNK2B 1460
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 POLR2H 5437
Co-fractionation Homo sapiens
48 LAMTOR1 55004
Proximity Label-MS Homo sapiens
49 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 SAMHD1 25939
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
51 POLR1A 25885
Co-fractionation Homo sapiens
52 PPM1B 5495
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
53 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
54 PPP1CA 5499
Affinity Capture-Western Homo sapiens
55 COMMD7 149951
Affinity Capture-Western Homo sapiens
56 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 IRAK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 RPL4 6124
Co-fractionation Homo sapiens
59 CCAR2 57805
Co-fractionation Homo sapiens
60 TAB3 257397
Affinity Capture-Western Homo sapiens
61 DPP4 1803
Affinity Capture-Western Homo sapiens
62 CCT8L2  
Affinity Capture-MS Homo sapiens
63 HTT 3064
Biochemical Activity Homo sapiens
64 CSF2RB  
Two-hybrid Homo sapiens
65 NLRC5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 MAP3K13 9175
Affinity Capture-Western Homo sapiens
67 RAN 5901
Affinity Capture-MS Homo sapiens
68 TRIM21 6737
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
69 COPS5 10987
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Biochemical Activity Homo sapiens
70 TAB2  
Biochemical Activity Homo sapiens
71 PLK1 5347
Biochemical Activity Homo sapiens
72 PPP2CA 5515
Affinity Capture-Western Homo sapiens
73 MEOX2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 UBC 7316
Reconstituted Complex Homo sapiens
75 HMGCL 3155
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
76 COPS3 8533
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
77 BRAP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 LATS2 26524
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
79 PRKCE 5581
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
80 KDF1  
Affinity Capture-MS Homo sapiens
81 TWIST1  
Biochemical Activity Homo sapiens
82 CD40 958
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
83 DUSP1  
Affinity Capture-Western Homo sapiens
84 USP4 7375
Affinity Capture-Western Homo sapiens
85 COPS7A 50813
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
86 SKP2  
Affinity Capture-Western Homo sapiens
87 MTIF2 4528
Co-fractionation Homo sapiens
88 EGLN3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
89 PPARG 5468
Protein-peptide Homo sapiens
90 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
91 NFKBIA  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
92 TNFRSF1A 7132
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
93 TRAF6 7189
Affinity Capture-Western Homo sapiens
94 CUL3 8452
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
95 RICTOR 253260
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
96 GLI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
97 MAP3K1 4214
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
98 METTL21B  
Affinity Capture-MS Homo sapiens
99 MAP3K7  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
100 TP73  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Biochemical Activity Homo sapiens
101 KPNA2 3838
Co-fractionation Homo sapiens
102 TNIP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
103 TROVE2 6738
Co-fractionation Homo sapiens
104 PRKCI 5584
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
105 JUN 3725
Biochemical Activity Homo sapiens
106 FBXW11  
Co-fractionation Homo sapiens
107 FANCA  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
108 POLR1E  
Co-fractionation Homo sapiens
109 MYC  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
110 SEC16A 9919
Co-fractionation Homo sapiens
111 MTOR 2475
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
112 TP63  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
113 TRIM27  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
114 Pebp1 29542
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
115 PRKY  
Affinity Capture-MS Homo sapiens
116 TRIM40 135644
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 CLTC 1213
Co-localization Homo sapiens
118 AKT1 207
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
119 CHUK 1147
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 NEDD4L 23327
Biochemical Activity Homo sapiens
121 SKP1 6500
Co-fractionation Homo sapiens
122 PPP1R15A  
Affinity Capture-Western Homo sapiens
123 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
124 IKBKAP 8518
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
125 MAP3K14  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
126 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
127 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
128 FOXO3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
129 TRAF2 7186
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
130 SMN1 6606
Affinity Capture-Western Homo sapiens
131 PSG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 ROCK1 6093
Biochemical Activity Homo sapiens
133 POLR1B 84172
Co-fractionation Homo sapiens
134 Snap23 20619
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
135 RPL6 6128
Co-fractionation Homo sapiens
136 PYGL 5836
Affinity Capture-MS Homo sapiens
137 NAA20  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
138 PYCARD 29108
Affinity Capture-Western Homo sapiens
139 KCTD14 65987
Affinity Capture-MS Homo sapiens
140 NFKB2 4791
Co-fractionation Homo sapiens
141 KEAP1 9817
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
142 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
143 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
144 CASP8 841
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
145 RPTOR 57521
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
146 HSPB1 3315
Affinity Capture-Western Homo sapiens
147 FKBP4 2288
Affinity Capture-MS Homo sapiens
148 CREBBP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
149 ITCH 83737
Affinity Capture-Western Homo sapiens
150 STK26 51765
Affinity Capture-Western Homo sapiens
151 BCL10  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
152 PRKCQ 5588
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
153 IRS1 3667
Affinity Capture-Western Homo sapiens
154 TP53 7157
Biochemical Activity Homo sapiens
155 GSTM3 2947
Affinity Capture-MS Homo sapiens
156 E2F4  
Biochemical Activity Homo sapiens
157 PPP2R3C  
Reconstituted Complex Homo sapiens
158 BCL2  
Affinity Capture-Western Homo sapiens
159 SASH1 23328
Affinity Capture-Western Homo sapiens
160 Cdc37 12539
Affinity Capture-MS Mus musculus
161 IQGAP2 10788
Co-fractionation Homo sapiens
162 PRKCA 5578
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
163 MAP3K11 4296
Biochemical Activity Homo sapiens
164 CUL4A 8451
Affinity Capture-MS Homo sapiens
165 GTF2E1 2960
Affinity Capture-MS Homo sapiens
166 FLNC 2318
Co-fractionation Homo sapiens
167 SHARPIN  
Affinity Capture-Western Homo sapiens
168 HNRNPU 3192
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
169 NFKBIB  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
170 PRKCB 5579
Co-localization Homo sapiens
171 COPS4 51138
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
172 IKBKB 3551
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
173 PRDX3 10935
Affinity Capture-Western Homo sapiens
174 KLHL21 9903
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
175 C19orf80  
Affinity Capture-Western Homo sapiens
176 TRPC4AP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
177 CDKN2A 1029
Affinity Capture-Western Homo sapiens
178 TRAF1 7185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IKBKB is involved
PathwayEvidenceSource
Activation of NF-kappaB in B cells TAS Reactome
Activation of NF-kappaB in B cells IEA Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Antigen processing-Cross presentation TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) IEA Reactome
Downstream TCR signaling TAS Reactome
ER-Phagosome pathway TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
IkBA variant leads to EDA-ID TAS Reactome
IKBKB deficiency causes SCID TAS Reactome
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interferon Signaling TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
IRAK1 recruits IKK complex TAS Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAS Reactome
MAP kinase activation TAS Reactome
MAP3K8 (TPL2)-dependent MAPK1/3 activation TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TAS Reactome
NF-kB is activated and signals survival TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
p75NTR recruits signalling complexes TAS Reactome
p75NTR signals via NF-kB TAS Reactome
PKR-mediated signaling TAS Reactome
Regulation of NF-kappa B signaling TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
RIP-mediated NFkB activation via ZBP1 TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
SLC15A4:TASL-dependent IRF5 activation TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TCR signaling TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells TAS Reactome
Viral Infection Pathways TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs TAS Reactome





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