Gene description for IKBKB
Gene name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Gene symbol	IKBKB
Other names/aliases	IKK-beta IKK2 IKKB IMD15 NFKBIKB
Species	Homo sapiens
Database cross references - IKBKB
ExoCarta	ExoCarta_3551
Entrez Gene	3551
HGNC	5960
MIM	603258
UniProt	O14920
IKBKB identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for IKBKB

Molecular Function     scaffold protein binding GO:0097110 IDA     protein heterodimerization activity GO:0046982 IDA     protein binding GO:0005515 IPI     IkappaB kinase activity GO:0008384 TAS     ATP binding GO:0005524 IEA     protein serine/threonine kinase activity GO:0004674 TAS     protein kinase binding GO:0019901 IPI     protein homodimerization activity GO:0042803 IDA     protein kinase activity GO:0004672 IDA Biological Process     cellular response to tumor necrosis factor GO:0071356 IDA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     serine phosphorylation of STAT protein GO:0042501 IDA     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS     positive regulation of type I interferon production GO:0032481 TAS     B cell homeostasis GO:0001782 IEA     positive regulation of sodium ion transport GO:0010765 IEA     toll-like receptor 2 signaling pathway GO:0034134 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     inflammatory response GO:0006954 TAS     negative regulation of apoptotic process GO:0043066 TAS     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     toll-like receptor signaling pathway GO:0002224 TAS     I-kappaB phosphorylation GO:0007252 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     response to virus GO:0009615 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     innate immune response GO:0045087 TAS     positive regulation of cation channel activity GO:2001259 IEA     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     T cell receptor signaling pathway GO:0050852 TAS     positive regulation of transcription, DNA-templated GO:0045893 NAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     protein phosphorylation GO:0006468 NAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS Subcellular Localization     CD40 receptor complex GO:0035631 ISS     cytosol GO:0005829 TAS     IkappaB kinase complex GO:0008385 TAS     membrane raft GO:0045121 IEA     cytoplasm GO:0005737 IDA     cytoplasmic side of plasma membrane GO:0009898 ISS     nucleus GO:0005634 IEA