Gene description for REL
Gene name v-rel avian reticuloendotheliosis viral oncogene homolog
Gene symbol REL
Other names/aliases C-Rel
Species Homo sapiens
 Database cross references - REL
ExoCarta ExoCarta_5966
Entrez Gene 5966
HGNC 9954
MIM 164910
UniProt Q04864  
 REL identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for REL
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    chromatin binding GO:0003682 IBA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IDA
    protein binding GO:0005515 IPI
Biological Process
    I-kappaB kinase/NF-kappaB signaling GO:0007249 IBA
    NIK/NF-kappaB signaling GO:0038061 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of interferon-beta production GO:0032688 IDA
    innate immune response GO:0045087 IBA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
    negative regulation of neuron death GO:1901215 IEA
    inflammatory response GO:0006954 IBA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP
    response to cytokine GO:0034097 IBA
    negative regulation of gene expression GO:0010629 IDA
    cytokine production GO:0001816 IEA
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of interleukin-12 biosynthetic process GO:0045084 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    I-kappaB/NF-kappaB complex GO:0033256 IBA
    transcription factor complex GO:0005667 IEA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IMP
 Experiment description of studies that identified REL in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for REL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFKB1 4790
Affinity Capture-MS Homo sapiens
2 SRF  
Reconstituted Complex Homo sapiens
3 SP1  
Reconstituted Complex Homo sapiens
4 TBP  
Reconstituted Complex Homo sapiens
5 TNIP2  
Affinity Capture-MS Homo sapiens
6 TBK1 29110
Affinity Capture-MS Homo sapiens
7 MAPK8 5599
Invivo Homo sapiens
Two-hybrid Homo sapiens
8 PPP4C 5531
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
9 ELF1 1997
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
11 CCNE1  
Invitro Homo sapiens
12 NFKB2 4791
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
13 RELA  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NKRF 55922
Invitro Homo sapiens
16 MAP3K8  
Affinity Capture-MS Homo sapiens
17 Nfkb1  
Phenotypic Enhancement Mus musculus
18 GTF2B 2959
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which REL is involved
Activation of NF-kappaB in B cells TAS Reactome

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