Gene description for NKRF
Gene name NFKB repressing factor
Gene symbol NKRF
Other names/aliases ITBA4
Species Homo sapiens
 Database cross references - NKRF
ExoCarta ExoCarta_55922
Entrez Gene 55922
HGNC 19374
MIM 300440
UniProt O15226  
 NKRF identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for NKRF
Molecular Function
    DNA binding GO:0003677 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified NKRF in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NKRF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFKB1 4790
Invitro Homo sapiens
2 RELA  
Invitro Homo sapiens
3 REL 5966
Invitro Homo sapiens
4 NFKB2 4791
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which NKRF is involved
No pathways found

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