Gene description for RC3H1
Gene name	ring finger and CCCH-type domains 1
Gene symbol	RC3H1
Other names/aliases	RNF198 ROQUIN
Species	Homo sapiens
Database cross references - RC3H1
ExoCarta	ExoCarta_149041
Vesiclepedia	VP_149041
Entrez Gene	149041
HGNC	29434
MIM	609424
UniProt	Q5TC82
RC3H1 identified in sEVs derived from the following tissue/cell type
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for RC3H1

Molecular Function     RNA binding GO:0003723 HDA     double-stranded RNA binding GO:0003725 IBA     double-stranded RNA binding GO:0003725 IDA     mRNA binding GO:0003729 IBA     mRNA 3'-UTR binding GO:0003730 ISS     ubiquitin-protein transferase activity GO:0004842 IDA     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 ISS     miRNA binding GO:0035198 ISS     RNA stem-loop binding GO:0035613 IBA     RNA stem-loop binding GO:0035613 IDA     RNA stem-loop binding GO:0035613 ISS     ubiquitin protein ligase activity GO:0061630 IBA     ubiquitin protein ligase activity GO:0061630 TAS     CCR4-NOT complex binding GO:1905762 IMP Biological Process     nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 ISS     protein polyubiquitination GO:0000209 IBA     protein polyubiquitination GO:0000209 IDA     nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 IBA     nuclear-transcribed mRNA catabolic process GO:0000956 IDA     nuclear-transcribed mRNA catabolic process GO:0000956 ISS     B cell homeostasis GO:0001782 IEA     regulation of germinal center formation GO:0002634 ISS     negative regulation of germinal center formation GO:0002635 ISS     ubiquitin-dependent protein catabolic process GO:0006511 IBA     post-transcriptional regulation of gene expression GO:0010608 ISS     negative regulation of B cell proliferation GO:0030889 ISS     P-body assembly GO:0033962 ISS     T cell proliferation GO:0042098 IEA     T cell homeostasis GO:0043029 IEA     regulation of mRNA stability GO:0043488 ISS     negative regulation of T-helper cell differentiation GO:0045623 ISS     negative regulation of activated T cell proliferation GO:0046007 ISS     lymph node development GO:0048535 IEA     spleen development GO:0048536 IEA     T cell receptor signaling pathway GO:0050852 ISS     regulation of T cell receptor signaling pathway GO:0050856 ISS     3'-UTR-mediated mRNA destabilization GO:0061158 ISS     T follicular helper cell differentiation GO:0061470 IEA     cellular response to interleukin-1 GO:0071347 ISS     regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900151 IMP     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IEA     negative regulation of T-helper 17 cell differentiation GO:2000320 ISS     regulation of miRNA metabolic process GO:2000628 ISS Subcellular Localization     P-body GO:0000932 IMP     P-body GO:0000932 ISS     cytoplasmic stress granule GO:0010494 IBA     cytoplasmic stress granule GO:0010494 ISS