Gene description for RC3H1
Gene name ring finger and CCCH-type domains 1
Gene symbol RC3H1
Other names/aliases RNF198
ROQUIN
Species Homo sapiens
 Database cross references - RC3H1
ExoCarta ExoCarta_149041
Entrez Gene 149041
HGNC 29434
MIM 609424
UniProt Q5TC82  
 RC3H1 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for RC3H1
Molecular Function
    mRNA 3'-UTR binding GO:0003730 ISS
    ubiquitin protein ligase activity GO:0061630 TAS
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    lymph node development GO:0048535 IEA
    negative regulation of activated T cell proliferation GO:0046007 ISS
    positive regulation of NIK/NF-kappaB signaling GO:1901224 IEA
    protein ubiquitination GO:0016567 TAS
    regulation of germinal center formation GO:0002634 ISS
    negative regulation of germinal center formation GO:0002635 ISS
    negative regulation of B cell proliferation GO:0030889 ISS
    spleen development GO:0048536 IEA
    cytoplasmic mRNA processing body assembly GO:0033962 ISS
    T cell homeostasis GO:0043029 IEA
    nuclear-transcribed mRNA catabolic process GO:0000956 ISS
    regulation of T cell receptor signaling pathway GO:0050856 ISS
    regulation of mRNA stability GO:0043488 ISS
    posttranscriptional regulation of gene expression GO:0010608 ISS
    T cell proliferation GO:0042098 IEA
    negative regulation of T-helper cell differentiation GO:0045623 ISS
    T follicular helper cell differentiation GO:0061470 IEA
    B cell homeostasis GO:0001782 IEA
Subcellular Localization
    cytoplasmic mRNA processing body GO:0000932 ISS
    cytoplasmic stress granule GO:0010494 ISS
 Experiment description of studies that identified RC3H1 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RC3H1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RC3H1 is involved
No pathways found





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