Gene description for EIF2B2
Gene name
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Gene symbol
EIF2B2
Other names/aliases
EIF-2Bbeta EIF2B
Species
Homo sapiens
Database cross references - EIF2B2
ExoCarta
ExoCarta_8892
Entrez Gene
8892
HGNC
3258
MIM
606454
UniProt
P49770
EIF2B2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells
20124223
Thymus
23844026
Gene ontology annotations for EIF2B2
Experiment description of studies that identified EIF2B2 in exosomes
1
Experiment ID
191
ISEV standards
✘
EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
20124223
Organism
Homo sapiens
Experiment description
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors
Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name
Mol Cell Proteomics
Publication year
2010
Sample
Squamous carcinoma cells
Sample name
Squamous carcinoma cell (A431)
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for EIF2B2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
EIF2S1
1965
Invivo
Homo sapiens
2
NCK1
4690
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
3
CCT3
7203
Two-hybrid
Homo sapiens
4
EIF2B4
8890
Affinity Capture-MS
Homo sapiens
5
EIF2B3
8891
Affinity Capture-MS
Homo sapiens
6
EIF2B5
8893
Reconstituted Complex
Homo sapiens
Reconstituted Complex
Homo sapiens
View the network
image/svg+xml
Pathways in which EIF2B2 is involved