Gene description for ENTPD2
Gene name ectonucleoside triphosphate diphosphohydrolase 2
Gene symbol ENTPD2
Other names/aliases CD39L1
NTPDase-2
Species Homo sapiens
 Database cross references - ENTPD2
ExoCarta ExoCarta_954
Vesiclepedia VP_954
Entrez Gene 954
HGNC 3364
MIM 602012
UniProt Q9Y5L3  
 ENTPD2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ENTPD2
Molecular Function
    GDP phosphatase activity GO:0004382 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ribonucleoside triphosphate phosphatase activity GO:0017111 IBA
    UDP phosphatase activity GO:0045134 IBA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    nucleoside diphosphate catabolic process GO:0009134 IBA
    purine ribonucleoside diphosphate catabolic process GO:0009181 IEA
    platelet activation GO:0030168 IEA
Subcellular Localization
    basement membrane GO:0005604 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ENTPD2 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ENTPD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HFE  
Affinity Capture-MS Homo sapiens
2 KLK15  
Affinity Capture-MS Homo sapiens
3 OCLN 100506658
Affinity Capture-MS Homo sapiens
4 EXTL2 2135
Affinity Capture-MS Homo sapiens
5 EIF2B2 8892
Affinity Capture-MS Homo sapiens
6 LGALS1 3956
Affinity Capture-MS Homo sapiens
7 GLB1L2  
Affinity Capture-MS Homo sapiens
8 B3GALT4  
Affinity Capture-MS Homo sapiens
9 PTPN1 5770
Affinity Capture-MS Homo sapiens
10 SLURP1  
Affinity Capture-MS Homo sapiens
11 ARL8B 55207
Affinity Capture-MS Homo sapiens
12 FAM20B 9917
Affinity Capture-MS Homo sapiens
13 TGFBR1 7046
Affinity Capture-MS Homo sapiens
14 PTDSS2 81490
Affinity Capture-MS Homo sapiens
15 SLC38A5 92745
Affinity Capture-MS Homo sapiens
16 ITFG1 81533
Affinity Capture-MS Homo sapiens
17 B3GNT2 10678
Affinity Capture-MS Homo sapiens
18 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
19 DCT 1638
Affinity Capture-MS Homo sapiens
20 ASIC1  
Affinity Capture-MS Homo sapiens
21 SLC39A11  
Affinity Capture-MS Homo sapiens
22 TMEM201 199953
Affinity Capture-MS Homo sapiens
23 DNAJC16  
Affinity Capture-MS Homo sapiens
24 ERMP1 79956
Affinity Capture-MS Homo sapiens
25 PIGG  
Affinity Capture-MS Homo sapiens
26 ELSPBP1  
Affinity Capture-MS Homo sapiens
27 BTNL2  
Affinity Capture-MS Homo sapiens
28 TMEM106A  
Affinity Capture-MS Homo sapiens
29 CLGN 1047
Affinity Capture-MS Homo sapiens
30 TMEM87A 25963
Affinity Capture-MS Homo sapiens
31 HLA-G 3135
Affinity Capture-MS Homo sapiens
32 ATP1A3 478
Affinity Capture-MS Homo sapiens
33 GLT8D1 55830
Affinity Capture-MS Homo sapiens
34 NOMO1 23420
Affinity Capture-MS Homo sapiens
35 SEC61A2 55176
Affinity Capture-MS Homo sapiens
36 EIF2B5 8893
Affinity Capture-MS Homo sapiens
37 PIGN 23556
Affinity Capture-MS Homo sapiens
38 PBXIP1 57326
Affinity Capture-MS Homo sapiens
39 SDF2L1 23753
Affinity Capture-MS Homo sapiens
40 NCR1  
Affinity Capture-MS Homo sapiens
41 ITM2C 81618
Affinity Capture-MS Homo sapiens
42 DNAJB9 4189
Affinity Capture-MS Homo sapiens
43 PREB 10113
Affinity Capture-MS Homo sapiens
44 PIGS 94005
Affinity Capture-MS Homo sapiens
45 EIF2B4 8890
Affinity Capture-MS Homo sapiens
46 SGCB 6443
Affinity Capture-MS Homo sapiens
47 MYADM 91663
Affinity Capture-MS Homo sapiens
48 GPAA1 8733
Affinity Capture-MS Homo sapiens
49 RAB25 57111
Affinity Capture-MS Homo sapiens
50 PDGFRA 5156
Affinity Capture-MS Homo sapiens
51 PRG2  
Affinity Capture-MS Homo sapiens
52 DAD1 1603
Affinity Capture-MS Homo sapiens
53 STIM1 6786
Affinity Capture-MS Homo sapiens
54 FBXO6 26270
Affinity Capture-MS Homo sapiens
55 HMBOX1  
Two-hybrid Homo sapiens
56 EIF2B3 8891
Affinity Capture-MS Homo sapiens
57 GHITM 27069
Affinity Capture-MS Homo sapiens
58 ECE1 1889
Affinity Capture-MS Homo sapiens
59 HGSNAT 138050
Affinity Capture-MS Homo sapiens
60 SAAL1 113174
Affinity Capture-MS Homo sapiens
61 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
62 ACSL3 2181
Affinity Capture-MS Homo sapiens
63 ATP2A1 487
Affinity Capture-MS Homo sapiens
64 TMCO1 54499
Affinity Capture-MS Homo sapiens
65 CERS6  
Affinity Capture-MS Homo sapiens
66 NCAPG2 54892
Affinity Capture-MS Homo sapiens
67 DCAKD 79877
Affinity Capture-MS Homo sapiens
68 RHEB 6009
Affinity Capture-MS Homo sapiens
69 RAB18 22931
Affinity Capture-MS Homo sapiens
70 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
71 GPR180  
Affinity Capture-MS Homo sapiens
72 EMC7 56851
Affinity Capture-MS Homo sapiens
73 ASIC4  
Affinity Capture-MS Homo sapiens
74 ARF5 381
Affinity Capture-MS Homo sapiens
75 CD1B 910
Affinity Capture-MS Homo sapiens
76 CD1A 909
Affinity Capture-MS Homo sapiens
77 LMAN2L 81562
Affinity Capture-MS Homo sapiens
78 CREB1  
Affinity Capture-MS Homo sapiens
79 SFTPC  
Affinity Capture-MS Homo sapiens
80 OGFOD3 79701
Affinity Capture-MS Homo sapiens
81 TEX264 51368
Affinity Capture-MS Homo sapiens
82 BRICD5  
Affinity Capture-MS Homo sapiens
83 GOLGA5 9950
Affinity Capture-MS Homo sapiens
84 SPPL2B 56928
Affinity Capture-MS Homo sapiens
85 RAB13 5872
Affinity Capture-MS Homo sapiens
86 STT3B 201595
Cross-Linking-MS (XL-MS) Homo sapiens
87 ADGRE5 976
Affinity Capture-MS Homo sapiens
88 HTR1B  
Affinity Capture-MS Homo sapiens
89 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
90 CLPTM1 1209
Affinity Capture-MS Homo sapiens
91 ATP13A1 57130
Affinity Capture-MS Homo sapiens
92 PCDHB3  
Affinity Capture-MS Homo sapiens
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