Gene description for ENTPD2
Gene name ectonucleoside triphosphate diphosphohydrolase 2
Gene symbol ENTPD2
Other names/aliases CD39L1
NTPDase-2
Species Homo sapiens
 Database cross references - ENTPD2
ExoCarta ExoCarta_954
Entrez Gene 954
HGNC 3364
MIM 602012
UniProt Q9Y5L3  
 ENTPD2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ENTPD2
Molecular Function
    nucleoside-diphosphatase activity GO:0017110 IEA
    ATP binding GO:0005524 IEA
    nucleoside-triphosphatase activity GO:0017111 IEA
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    platelet activation GO:0030168 IEA
    purine ribonucleoside diphosphate catabolic process GO:0009181 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IDA
    basal lamina GO:0005605 IEA
 Experiment description of studies that identified ENTPD2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ENTPD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ENTPD2 is involved
No pathways found





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