Gene description for ENTPD2
Gene name ectonucleoside triphosphate diphosphohydrolase 2
Gene symbol ENTPD2
Other names/aliases CD39L1
NTPDase-2
Species Homo sapiens
 Database cross references - ENTPD2
ExoCarta ExoCarta_954
Vesiclepedia VP_954
Entrez Gene 954
HGNC 3364
MIM 602012
UniProt Q9Y5L3  
 ENTPD2 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ENTPD2
Molecular Function
    GDP phosphatase activity GO:0004382 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ribonucleoside triphosphate phosphatase activity GO:0017111 IBA
    UDP phosphatase activity GO:0045134 IBA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    nucleoside diphosphate catabolic process GO:0009134 IBA
    purine ribonucleoside diphosphate catabolic process GO:0009181 IEA
    platelet activation GO:0030168 IEA
Subcellular Localization
    basement membrane GO:0005604 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ENTPD2 in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ENTPD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HFE  
Affinity Capture-MS Homo sapiens
2 KLK15  
Affinity Capture-MS Homo sapiens
3 OCLN 100506658
Affinity Capture-MS Homo sapiens
4 EXTL2 2135
Affinity Capture-MS Homo sapiens
5 EIF2B2 8892
Affinity Capture-MS Homo sapiens
6 LGALS1 3956
Affinity Capture-MS Homo sapiens
7 GLB1L2  
Affinity Capture-MS Homo sapiens
8 B3GALT4  
Affinity Capture-MS Homo sapiens
9 PTPN1 5770
Affinity Capture-MS Homo sapiens
10 SLURP1  
Affinity Capture-MS Homo sapiens
11 ARL8B 55207
Affinity Capture-MS Homo sapiens
12 FAM20B 9917
Affinity Capture-MS Homo sapiens
13 TGFBR1 7046
Affinity Capture-MS Homo sapiens
14 PTDSS2 81490
Affinity Capture-MS Homo sapiens
15 SLC38A5 92745
Affinity Capture-MS Homo sapiens
16 ITFG1 81533
Affinity Capture-MS Homo sapiens
17 B3GNT2 10678
Affinity Capture-MS Homo sapiens
18 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
19 DCT 1638
Affinity Capture-MS Homo sapiens
20 ASIC1  
Affinity Capture-MS Homo sapiens
21 SLC39A11  
Affinity Capture-MS Homo sapiens
22 TMEM201 199953
Affinity Capture-MS Homo sapiens
23 DNAJC16  
Affinity Capture-MS Homo sapiens
24 ERMP1 79956
Affinity Capture-MS Homo sapiens
25 PIGG  
Affinity Capture-MS Homo sapiens
26 ELSPBP1  
Affinity Capture-MS Homo sapiens
27 BTNL2  
Affinity Capture-MS Homo sapiens
28 TMEM106A  
Affinity Capture-MS Homo sapiens
29 CLGN 1047
Affinity Capture-MS Homo sapiens
30 TMEM87A 25963
Affinity Capture-MS Homo sapiens
31 HLA-G 3135
Affinity Capture-MS Homo sapiens
32 ATP1A3 478
Affinity Capture-MS Homo sapiens
33 GLT8D1 55830
Affinity Capture-MS Homo sapiens
34 NOMO1 23420
Affinity Capture-MS Homo sapiens
35 SEC61A2 55176
Affinity Capture-MS Homo sapiens
36 EIF2B5 8893
Affinity Capture-MS Homo sapiens
37 PIGN 23556
Affinity Capture-MS Homo sapiens
38 PBXIP1 57326
Affinity Capture-MS Homo sapiens
39 SDF2L1 23753
Affinity Capture-MS Homo sapiens
40 NCR1  
Affinity Capture-MS Homo sapiens
41 ITM2C 81618
Affinity Capture-MS Homo sapiens
42 DNAJB9 4189
Affinity Capture-MS Homo sapiens
43 PREB 10113
Affinity Capture-MS Homo sapiens
44 PIGS 94005
Affinity Capture-MS Homo sapiens
45 EIF2B4 8890
Affinity Capture-MS Homo sapiens
46 SGCB 6443
Affinity Capture-MS Homo sapiens
47 MYADM 91663
Affinity Capture-MS Homo sapiens
48 GPAA1 8733
Affinity Capture-MS Homo sapiens
49 RAB25 57111
Affinity Capture-MS Homo sapiens
50 PDGFRA 5156
Affinity Capture-MS Homo sapiens
51 PRG2  
Affinity Capture-MS Homo sapiens
52 DAD1 1603
Affinity Capture-MS Homo sapiens
53 STIM1 6786
Affinity Capture-MS Homo sapiens
54 FBXO6 26270
Affinity Capture-MS Homo sapiens
55 HMBOX1  
Two-hybrid Homo sapiens
56 EIF2B3 8891
Affinity Capture-MS Homo sapiens
57 GHITM 27069
Affinity Capture-MS Homo sapiens
58 ECE1 1889
Affinity Capture-MS Homo sapiens
59 HGSNAT 138050
Affinity Capture-MS Homo sapiens
60 SAAL1 113174
Affinity Capture-MS Homo sapiens
61 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
62 ACSL3 2181
Affinity Capture-MS Homo sapiens
63 ATP2A1 487
Affinity Capture-MS Homo sapiens
64 TMCO1 54499
Affinity Capture-MS Homo sapiens
65 CERS6  
Affinity Capture-MS Homo sapiens
66 NCAPG2 54892
Affinity Capture-MS Homo sapiens
67 DCAKD 79877
Affinity Capture-MS Homo sapiens
68 RHEB 6009
Affinity Capture-MS Homo sapiens
69 RAB18 22931
Affinity Capture-MS Homo sapiens
70 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
71 GPR180  
Affinity Capture-MS Homo sapiens
72 EMC7 56851
Affinity Capture-MS Homo sapiens
73 ASIC4  
Affinity Capture-MS Homo sapiens
74 ARF5 381
Affinity Capture-MS Homo sapiens
75 CD1B 910
Affinity Capture-MS Homo sapiens
76 CD1A 909
Affinity Capture-MS Homo sapiens
77 LMAN2L 81562
Affinity Capture-MS Homo sapiens
78 CREB1  
Affinity Capture-MS Homo sapiens
79 SFTPC  
Affinity Capture-MS Homo sapiens
80 OGFOD3 79701
Affinity Capture-MS Homo sapiens
81 TEX264 51368
Affinity Capture-MS Homo sapiens
82 BRICD5  
Affinity Capture-MS Homo sapiens
83 GOLGA5 9950
Affinity Capture-MS Homo sapiens
84 SPPL2B 56928
Affinity Capture-MS Homo sapiens
85 RAB13 5872
Affinity Capture-MS Homo sapiens
86 STT3B 201595
Cross-Linking-MS (XL-MS) Homo sapiens
87 ADGRE5 976
Affinity Capture-MS Homo sapiens
88 HTR1B  
Affinity Capture-MS Homo sapiens
89 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
90 CLPTM1 1209
Affinity Capture-MS Homo sapiens
91 ATP13A1 57130
Affinity Capture-MS Homo sapiens
92 PCDHB3  
Affinity Capture-MS Homo sapiens
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