Gene description for TMCO1
Gene name transmembrane and coiled-coil domains 1
Gene symbol TMCO1
Other names/aliases HP10122
PCIA3
PNAS-136
TMCC4
Species Homo sapiens
 Database cross references - TMCO1
ExoCarta ExoCarta_54499
Entrez Gene 54499
HGNC 18188
MIM 614123
UniProt Q9UM00  
 TMCO1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TMCO1
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    integral component of membrane GO:0016021 IEA
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified TMCO1 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMCO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMCO1 is involved
No pathways found





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